Genome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh; Claire M Wade; Tarjei S Mikkelsen; Elinor K Karlsson; David B Jaffe; Michael Kamal; Michele Clamp; Jean L Chang; Edward J Kulbokas; Michael C Zody; Evan Mauceli; Xiaohui Xie; Matthew Breen; Robert K Wayne; Elaine A Ostrander; Chris P Ponting; Francis Galibert; Douglas R Smith; Pieter J DeJong; Ewen Kirkness; Pablo Alvarez; Tara Biagi; William Brockman; Jonathan Butler; Chee-Wye Chin; April Cook; James Cuff; Mark J Daly; David DeCaprio; Sante Gnerre; Manfred Grabherr; Manolis Kellis; Michael Kleber; Carolyne Bardeleben; Leo Goodstadt; Andreas Heger; Christophe Hitte; Lisa Kim; Klaus-Peter Koepfli; Heidi G Parker; John P Pollinger; Stephen M J Searle; Nathan B Sutter; Rachael Thomas; Caleb Webber; Jennifer Baldwin; Adal Abebe; Amr Abouelleil; Lynne Aftuck; Mostafa Ait-Zahra; Tyler Aldredge; Nicole Allen; Peter An; Scott Anderson; Claudel Antoine; Harindra Arachchi; Ali Aslam; Laura Ayotte; Pasang Bachantsang; Andrew Barry; Tashi Bayul; Mostafa Benamara; Aaron Berlin; Daniel Bessette; Berta Blitshteyn; Toby Bloom; Jason Blye; Leonid Boguslavskiy; Claude Bonnet; Boris Boukhgalter; Adam Brown; Patrick Cahill; Nadia Calixte; Jody Camarata; Yama Cheshatsang; Jeffrey Chu; Mieke Citroen; Alville Collymore; Patrick Cooke; Tenzin Dawoe; Riza Daza; Karin Decktor; Stuart DeGray; Norbu Dhargay; Kimberly Dooley; Kathleen Dooley; Passang Dorje; Kunsang Dorjee; Lester Dorris; Noah Duffey; Alan Dupes; Osebhajajeme Egbiremolen; Richard Elong; Jill Falk; Abderrahim Farina; Susan Faro; Diallo Ferguson; Patricia Ferreira; Sheila Fisher; Mike FitzGerald; Karen Foley; Chelsea Foley; Alicia Franke; Dennis Friedrich; Diane Gage; Manuel Garber; Gary Gearin; Georgia Giannoukos; Tina Goode; Audra Goyette; Joseph Graham; Edward Grandbois; Kunsang Gyaltsen; Nabil Hafez; Daniel Hagopian; Birhane Hagos; Jennifer Hall; Claire Healy; Ryan Hegarty; Tracey Honan; Andrea Horn; Nathan Houde; Leanne Hughes; Leigh Hunnicutt; M Husby; Benjamin Jester; Charlien Jones; Asha Kamat; Ben Kanga; Cristyn Kells; Dmitry Khazanovich; Alix Chinh Kieu; Peter Kisner; Mayank Kumar; Krista Lance; Thomas Landers; Marcia Lara; William Lee; Jean-Pierre Leger; Niall Lennon; Lisa Leuper; Sarah LeVine; Jinlei Liu; Xiaohong Liu; Yeshi Lokyitsang; Tashi Lokyitsang; Annie Lui; Jan Macdonald; John Major; Richard Marabella; Kebede Maru; Charles Matthews; Susan McDonough; Teena Mehta; James Meldrim; Alexandre Melnikov; Louis Meneus; Atanas Mihalev; Tanya Mihova; Karen Miller; Rachel Mittelman; Valentine Mlenga; Leonidas Mulrain; Glen Munson; Adam Navidi; Jerome Naylor; Tuyen Nguyen; Nga Nguyen; Cindy Nguyen; Thu Nguyen; Robert Nicol; Nyima Norbu; Choe Norbu; Nathaniel Novod; Tenchoe Nyima; Peter Olandt; Barry O'Neill; Keith O'Neill; Sahal Osman; Lucien Oyono; Christopher Patti; Danielle Perrin; Pema Phunkhang; Fritz Pierre; Margaret Priest; Anthony Rachupka; Sujaa Raghuraman; Rayale Rameau; Verneda Ray; Christina Raymond; Filip Rege; Cecil Rise; Julie Rogers; Peter Rogov; Julie Sahalie; Sampath Settipalli; Theodore Sharpe; Terrance Shea; Mechele Sheehan; Ngawang Sherpa; Jianying Shi; Diana Shih; Jessie Sloan; Cherylyn Smith; Todd Sparrow; John Stalker; Nicole Stange-Thomann; Sharon Stavropoulos; Catherine Stone; Sabrina Stone; Sean Sykes; Pierre Tchuinga; Pema Tenzing; Senait Tesfaye; Dawa Thoulutsang; Yama Thoulutsang; Kerri Topham; Ira Topping; Tsamla Tsamla; Helen Vassiliev; Vijay Venkataraman; Andy Vo; Tsering Wangchuk; Tsering Wangdi; Michael Weiand; Jane Wilkinson; Adam Wilson; Shailendra Yadav; Shuli Yang; Xiaoping Yang; Geneva Young; Qing Yu; Joanne Zainoun; Lisa Zembek; Andrew Zimmer; Eric S Lander

doi:10.1038/nature04338

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Kerstin Lindblad-Toh, Claire M Wade, Tarjei S Mikkelsen, Elinor K Karlsson, David B Jaffe, Michael Kamal, Michele Clamp, Jean L Chang, Edward J Kulbokas, Michael C Zody, Evan Mauceli, Xiaohui Xie, Matthew Breen, Robert K Wayne, Elaine A Ostrander, Chris P Ponting, Francis Galibert, Douglas R Smith, Pieter J DeJong, Ewen KirknessPablo Alvarez, Tara Biagi, William Brockman, Jonathan Butler, Chee-Wye Chin, April Cook, James Cuff, Mark J Daly, David DeCaprio, Sante Gnerre, Manfred Grabherr, Manolis Kellis, Michael Kleber, Carolyne Bardeleben, Leo Goodstadt, Andreas Heger, Christophe Hitte, Lisa Kim, Klaus-Peter Koepfli, Heidi G Parker, John P Pollinger, Stephen M J Searle, Nathan B Sutter, Rachael Thomas, Caleb Webber, Jennifer Baldwin, Adal Abebe, Amr Abouelleil, Lynne Aftuck, Mostafa Ait-Zahra, Tyler Aldredge, Nicole Allen, Peter An, Scott Anderson, Claudel Antoine, Harindra Arachchi, Ali Aslam, Laura Ayotte, Pasang Bachantsang, Andrew Barry, Tashi Bayul, Mostafa Benamara, Aaron Berlin, Daniel Bessette, Berta Blitshteyn, Toby Bloom, Jason Blye, Leonid Boguslavskiy, Claude Bonnet, Boris Boukhgalter, Adam Brown, Patrick Cahill, Nadia Calixte, Jody Camarata, Yama Cheshatsang, Jeffrey Chu, Mieke Citroen, Alville Collymore, Patrick Cooke, Tenzin Dawoe, Riza Daza, Karin Decktor, Stuart DeGray, Norbu Dhargay, Kimberly Dooley, Kathleen Dooley, Passang Dorje, Kunsang Dorjee, Lester Dorris, Noah Duffey, Alan Dupes, Osebhajajeme Egbiremolen, Richard Elong, Jill Falk, Abderrahim Farina, Susan Faro, Diallo Ferguson, Patricia Ferreira, Sheila Fisher, Mike FitzGerald, Karen Foley, Chelsea Foley, Alicia Franke, Dennis Friedrich, Diane Gage, Manuel Garber, Gary Gearin, Georgia Giannoukos, Tina Goode, Audra Goyette, Joseph Graham, Edward Grandbois, Kunsang Gyaltsen, Nabil Hafez, Daniel Hagopian, Birhane Hagos, Jennifer Hall, Claire Healy, Ryan Hegarty, Tracey Honan, Andrea Horn, Nathan Houde, Leanne Hughes, Leigh Hunnicutt, M Husby, Benjamin Jester, Charlien Jones, Asha Kamat, Ben Kanga, Cristyn Kells, Dmitry Khazanovich, Alix Chinh Kieu, Peter Kisner, Mayank Kumar, Krista Lance, Thomas Landers, Marcia Lara, William Lee, Jean-Pierre Leger, Niall Lennon, Lisa Leuper, Sarah LeVine, Jinlei Liu, Xiaohong Liu, Yeshi Lokyitsang, Tashi Lokyitsang, Annie Lui, Jan Macdonald, John Major, Richard Marabella, Kebede Maru, Charles Matthews, Susan McDonough, Teena Mehta, James Meldrim, Alexandre Melnikov, Louis Meneus, Atanas Mihalev, Tanya Mihova, Karen Miller, Rachel Mittelman, Valentine Mlenga, Leonidas Mulrain, Glen Munson, Adam Navidi, Jerome Naylor, Tuyen Nguyen, Nga Nguyen, Cindy Nguyen, Thu Nguyen, Robert Nicol, Nyima Norbu, Choe Norbu, Nathaniel Novod, Tenchoe Nyima, Peter Olandt, Barry O'Neill, Keith O'Neill, Sahal Osman, Lucien Oyono, Christopher Patti, Danielle Perrin, Pema Phunkhang, Fritz Pierre, Margaret Priest, Anthony Rachupka, Sujaa Raghuraman, Rayale Rameau, Verneda Ray, Christina Raymond, Filip Rege, Cecil Rise, Julie Rogers, Peter Rogov, Julie Sahalie, Sampath Settipalli, Theodore Sharpe, Terrance Shea, Mechele Sheehan, Ngawang Sherpa, Jianying Shi, Diana Shih, Jessie Sloan, Cherylyn Smith, Todd Sparrow, John Stalker, Nicole Stange-Thomann, Sharon Stavropoulos, Catherine Stone, Sabrina Stone, Sean Sykes, Pierre Tchuinga, Pema Tenzing, Senait Tesfaye, Dawa Thoulutsang, Yama Thoulutsang, Kerri Topham, Ira Topping, Tsamla Tsamla, Helen Vassiliev, Vijay Venkataraman, Andy Vo, Tsering Wangchuk, Tsering Wangdi, Michael Weiand, Jane Wilkinson, Adam Wilson, Shailendra Yadav, Shuli Yang, Xiaoping Yang, Geneva Young, Qing Yu, Joanne Zainoun, Lisa Zembek, Andrew Zimmer, Eric S Lander

Research output: Contribution to journal › Article › peer-review

Abstract

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

Original language	English
Pages (from-to)	803-19
Number of pages	17
Journal	Nature
Volume	438
Issue number	7069
DOIs	https://doi.org/10.1038/nature04338
Publication status	Published - 8 Dec 2005

Keywords / Materials (for Non-textual outputs)

Animals
Conserved Sequence
Dog Diseases
Dogs
Evolution, Molecular
Female
Genome
Genomics
Haplotypes
Humans
Hybridization, Genetic
Male
Mice
Mutagenesis
Polymorphism, Single Nucleotide
Rats
Short Interspersed Nucleotide Elements
Synteny

Access to Document

10.1038/nature04338

Cite this

Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., Zody, M. C., Mauceli, E., Xie, X., Breen, M., Wayne, R. K., Ostrander, E. A., Ponting, C. P., Galibert, F., Smith, D. R., DeJong, P. J., ... Lander, E. S. (2005). Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature, 438(7069), 803-19. https://doi.org/10.1038/nature04338

@article{a02b619092544b2d9360788a1fd2ec94,

title = "Genome sequence, comparative analysis and haplotype structure of the domestic dog",

abstract = "Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.",

keywords = "Animals, Conserved Sequence, Dog Diseases, Dogs, Evolution, Molecular, Female, Genome, Genomics, Haplotypes, Humans, Hybridization, Genetic, Male, Mice, Mutagenesis, Polymorphism, Single Nucleotide, Rats, Short Interspersed Nucleotide Elements, Synteny",

author = "Kerstin Lindblad-Toh and Wade, {Claire M} and Mikkelsen, {Tarjei S} and Karlsson, {Elinor K} and Jaffe, {David B} and Michael Kamal and Michele Clamp and Chang, {Jean L} and Kulbokas, {Edward J} and Zody, {Michael C} and Evan Mauceli and Xiaohui Xie and Matthew Breen and Wayne, {Robert K} and Ostrander, {Elaine A} and Ponting, {Chris P} and Francis Galibert and Smith, {Douglas R} and DeJong, {Pieter J} and Ewen Kirkness and Pablo Alvarez and Tara Biagi and William Brockman and Jonathan Butler and Chee-Wye Chin and April Cook and James Cuff and Daly, {Mark J} and David DeCaprio and Sante Gnerre and Manfred Grabherr and Manolis Kellis and Michael Kleber and Carolyne Bardeleben and Leo Goodstadt and Andreas Heger and Christophe Hitte and Lisa Kim and Klaus-Peter Koepfli and Parker, {Heidi G} and Pollinger, {John P} and Searle, {Stephen M J} and Sutter, {Nathan B} and Rachael Thomas and Caleb Webber and Jennifer Baldwin and Adal Abebe and Amr Abouelleil and Lynne Aftuck and Mostafa Ait-Zahra and Tyler Aldredge and Nicole Allen and Peter An and Scott Anderson and Claudel Antoine and Harindra Arachchi and Ali Aslam and Laura Ayotte and Pasang Bachantsang and Andrew Barry and Tashi Bayul and Mostafa Benamara and Aaron Berlin and Daniel Bessette and Berta Blitshteyn and Toby Bloom and Jason Blye and Leonid Boguslavskiy and Claude Bonnet and Boris Boukhgalter and Adam Brown and Patrick Cahill and Nadia Calixte and Jody Camarata and Yama Cheshatsang and Jeffrey Chu and Mieke Citroen and Alville Collymore and Patrick Cooke and Tenzin Dawoe and Riza Daza and Karin Decktor and Stuart DeGray and Norbu Dhargay and Kimberly Dooley and Kathleen Dooley and Passang Dorje and Kunsang Dorjee and Lester Dorris and Noah Duffey and Alan Dupes and Osebhajajeme Egbiremolen and Richard Elong and Jill Falk and Abderrahim Farina and Susan Faro and Diallo Ferguson and Patricia Ferreira and Sheila Fisher and Mike FitzGerald and Karen Foley and Chelsea Foley and Alicia Franke and Dennis Friedrich and Diane Gage and Manuel Garber and Gary Gearin and Georgia Giannoukos and Tina Goode and Audra Goyette and Joseph Graham and Edward Grandbois and Kunsang Gyaltsen and Nabil Hafez and Daniel Hagopian and Birhane Hagos and Jennifer Hall and Claire Healy and Ryan Hegarty and Tracey Honan and Andrea Horn and Nathan Houde and Leanne Hughes and Leigh Hunnicutt and M Husby and Benjamin Jester and Charlien Jones and Asha Kamat and Ben Kanga and Cristyn Kells and Dmitry Khazanovich and Kieu, {Alix Chinh} and Peter Kisner and Mayank Kumar and Krista Lance and Thomas Landers and Marcia Lara and William Lee and Jean-Pierre Leger and Niall Lennon and Lisa Leuper and Sarah LeVine and Jinlei Liu and Xiaohong Liu and Yeshi Lokyitsang and Tashi Lokyitsang and Annie Lui and Jan Macdonald and John Major and Richard Marabella and Kebede Maru and Charles Matthews and Susan McDonough and Teena Mehta and James Meldrim and Alexandre Melnikov and Louis Meneus and Atanas Mihalev and Tanya Mihova and Karen Miller and Rachel Mittelman and Valentine Mlenga and Leonidas Mulrain and Glen Munson and Adam Navidi and Jerome Naylor and Tuyen Nguyen and Nga Nguyen and Cindy Nguyen and Thu Nguyen and Robert Nicol and Nyima Norbu and Choe Norbu and Nathaniel Novod and Tenchoe Nyima and Peter Olandt and Barry O'Neill and Keith O'Neill and Sahal Osman and Lucien Oyono and Christopher Patti and Danielle Perrin and Pema Phunkhang and Fritz Pierre and Margaret Priest and Anthony Rachupka and Sujaa Raghuraman and Rayale Rameau and Verneda Ray and Christina Raymond and Filip Rege and Cecil Rise and Julie Rogers and Peter Rogov and Julie Sahalie and Sampath Settipalli and Theodore Sharpe and Terrance Shea and Mechele Sheehan and Ngawang Sherpa and Jianying Shi and Diana Shih and Jessie Sloan and Cherylyn Smith and Todd Sparrow and John Stalker and Nicole Stange-Thomann and Sharon Stavropoulos and Catherine Stone and Sabrina Stone and Sean Sykes and Pierre Tchuinga and Pema Tenzing and Senait Tesfaye and Dawa Thoulutsang and Yama Thoulutsang and Kerri Topham and Ira Topping and Tsamla Tsamla and Helen Vassiliev and Vijay Venkataraman and Andy Vo and Tsering Wangchuk and Tsering Wangdi and Michael Weiand and Jane Wilkinson and Adam Wilson and Shailendra Yadav and Shuli Yang and Xiaoping Yang and Geneva Young and Qing Yu and Joanne Zainoun and Lisa Zembek and Andrew Zimmer and Lander, {Eric S}",

year = "2005",

month = dec,

day = "8",

doi = "10.1038/nature04338",

language = "English",

volume = "438",

pages = "803--19",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "7069",

}

Lindblad-Toh, K, Wade, CM, Mikkelsen, TS, Karlsson, EK, Jaffe, DB, Kamal, M, Clamp, M, Chang, JL, Kulbokas, EJ, Zody, MC, Mauceli, E, Xie, X, Breen, M, Wayne, RK, Ostrander, EA, Ponting, CP, Galibert, F, Smith, DR, DeJong, PJ, Kirkness, E, Alvarez, P, Biagi, T, Brockman, W, Butler, J, Chin, C-W, Cook, A, Cuff, J, Daly, MJ, DeCaprio, D, Gnerre, S, Grabherr, M, Kellis, M, Kleber, M, Bardeleben, C, Goodstadt, L, Heger, A, Hitte, C, Kim, L, Koepfli, K-P, Parker, HG, Pollinger, JP, Searle, SMJ, Sutter, NB, Thomas, R, Webber, C, Baldwin, J, Abebe, A, Abouelleil, A, Aftuck, L, Ait-Zahra, M, Aldredge, T, Allen, N, An, P, Anderson, S, Antoine, C, Arachchi, H, Aslam, A, Ayotte, L, Bachantsang, P, Barry, A, Bayul, T, Benamara, M, Berlin, A, Bessette, D, Blitshteyn, B, Bloom, T, Blye, J, Boguslavskiy, L, Bonnet, C, Boukhgalter, B, Brown, A, Cahill, P, Calixte, N, Camarata, J, Cheshatsang, Y, Chu, J, Citroen, M, Collymore, A, Cooke, P, Dawoe, T, Daza, R, Decktor, K, DeGray, S, Dhargay, N, Dooley, K, Dooley, K, Dorje, P, Dorjee, K, Dorris, L, Duffey, N, Dupes, A, Egbiremolen, O, Elong, R, Falk, J, Farina, A, Faro, S, Ferguson, D, Ferreira, P, Fisher, S, FitzGerald, M, Foley, K, Foley, C, Franke, A, Friedrich, D, Gage, D, Garber, M, Gearin, G, Giannoukos, G, Goode, T, Goyette, A, Graham, J, Grandbois, E, Gyaltsen, K, Hafez, N, Hagopian, D, Hagos, B, Hall, J, Healy, C, Hegarty, R, Honan, T, Horn, A, Houde, N, Hughes, L, Hunnicutt, L, Husby, M, Jester, B, Jones, C, Kamat, A, Kanga, B, Kells, C, Khazanovich, D, Kieu, AC, Kisner, P, Kumar, M, Lance, K, Landers, T, Lara, M, Lee, W, Leger, J-P, Lennon, N, Leuper, L, LeVine, S, Liu, J, Liu, X, Lokyitsang, Y, Lokyitsang, T, Lui, A, Macdonald, J, Major, J, Marabella, R, Maru, K, Matthews, C, McDonough, S, Mehta, T, Meldrim, J, Melnikov, A, Meneus, L, Mihalev, A, Mihova, T, Miller, K, Mittelman, R, Mlenga, V, Mulrain, L, Munson, G, Navidi, A, Naylor, J, Nguyen, T, Nguyen, N, Nguyen, C, Nguyen, T, Nicol, R, Norbu, N, Norbu, C, Novod, N, Nyima, T, Olandt, P, O'Neill, B, O'Neill, K, Osman, S, Oyono, L, Patti, C, Perrin, D, Phunkhang, P, Pierre, F, Priest, M, Rachupka, A, Raghuraman, S, Rameau, R, Ray, V, Raymond, C, Rege, F, Rise, C, Rogers, J, Rogov, P, Sahalie, J, Settipalli, S, Sharpe, T, Shea, T, Sheehan, M, Sherpa, N, Shi, J, Shih, D, Sloan, J, Smith, C, Sparrow, T, Stalker, J, Stange-Thomann, N, Stavropoulos, S, Stone, C, Stone, S, Sykes, S, Tchuinga, P, Tenzing, P, Tesfaye, S, Thoulutsang, D, Thoulutsang, Y, Topham, K, Topping, I, Tsamla, T, Vassiliev, H, Venkataraman, V, Vo, A, Wangchuk, T, Wangdi, T, Weiand, M, Wilkinson, J, Wilson, A, Yadav, S, Yang, S, Yang, X, Young, G, Yu, Q, Zainoun, J, Zembek, L, Zimmer, A & Lander, ES 2005, 'Genome sequence, comparative analysis and haplotype structure of the domestic dog', Nature, vol. 438, no. 7069, pp. 803-19. https://doi.org/10.1038/nature04338

TY - JOUR

T1 - Genome sequence, comparative analysis and haplotype structure of the domestic dog

AU - Lindblad-Toh, Kerstin

AU - Wade, Claire M

AU - Mikkelsen, Tarjei S

AU - Karlsson, Elinor K

AU - Jaffe, David B

AU - Kamal, Michael

AU - Clamp, Michele

AU - Chang, Jean L

AU - Kulbokas, Edward J

AU - Zody, Michael C

AU - Mauceli, Evan

AU - Xie, Xiaohui

AU - Breen, Matthew

AU - Wayne, Robert K

AU - Ostrander, Elaine A

AU - Ponting, Chris P

AU - Galibert, Francis

AU - Smith, Douglas R

AU - DeJong, Pieter J

AU - Kirkness, Ewen

AU - Alvarez, Pablo

AU - Biagi, Tara

AU - Brockman, William

AU - Butler, Jonathan

AU - Chin, Chee-Wye

AU - Cook, April

AU - Cuff, James

AU - Daly, Mark J

AU - DeCaprio, David

AU - Gnerre, Sante

AU - Grabherr, Manfred

AU - Kellis, Manolis

AU - Kleber, Michael

AU - Bardeleben, Carolyne

AU - Goodstadt, Leo

AU - Heger, Andreas

AU - Hitte, Christophe

AU - Kim, Lisa

AU - Koepfli, Klaus-Peter

AU - Parker, Heidi G

AU - Pollinger, John P

AU - Searle, Stephen M J

AU - Sutter, Nathan B

AU - Thomas, Rachael

AU - Webber, Caleb

AU - Baldwin, Jennifer

AU - Abebe, Adal

AU - Abouelleil, Amr

AU - Aftuck, Lynne

AU - Ait-Zahra, Mostafa

AU - Aldredge, Tyler

AU - Allen, Nicole

AU - An, Peter

AU - Anderson, Scott

AU - Antoine, Claudel

AU - Arachchi, Harindra

AU - Aslam, Ali

AU - Ayotte, Laura

AU - Bachantsang, Pasang

AU - Barry, Andrew

AU - Bayul, Tashi

AU - Benamara, Mostafa

AU - Berlin, Aaron

AU - Bessette, Daniel

AU - Blitshteyn, Berta

AU - Bloom, Toby

AU - Blye, Jason

AU - Boguslavskiy, Leonid

AU - Bonnet, Claude

AU - Boukhgalter, Boris

AU - Brown, Adam

AU - Cahill, Patrick

AU - Calixte, Nadia

AU - Camarata, Jody

AU - Cheshatsang, Yama

AU - Chu, Jeffrey

AU - Citroen, Mieke

AU - Collymore, Alville

AU - Cooke, Patrick

AU - Dawoe, Tenzin

AU - Daza, Riza

AU - Decktor, Karin

AU - DeGray, Stuart

AU - Dhargay, Norbu

AU - Dooley, Kimberly

AU - Dooley, Kathleen

AU - Dorje, Passang

AU - Dorjee, Kunsang

AU - Dorris, Lester

AU - Duffey, Noah

AU - Dupes, Alan

AU - Egbiremolen, Osebhajajeme

AU - Elong, Richard

AU - Falk, Jill

AU - Farina, Abderrahim

AU - Faro, Susan

AU - Ferguson, Diallo

AU - Ferreira, Patricia

AU - Fisher, Sheila

AU - FitzGerald, Mike

AU - Foley, Karen

AU - Foley, Chelsea

AU - Franke, Alicia

AU - Friedrich, Dennis

AU - Gage, Diane

AU - Garber, Manuel

AU - Gearin, Gary

AU - Giannoukos, Georgia

AU - Goode, Tina

AU - Goyette, Audra

AU - Graham, Joseph

AU - Grandbois, Edward

AU - Gyaltsen, Kunsang

AU - Hafez, Nabil

AU - Hagopian, Daniel

AU - Hagos, Birhane

AU - Hall, Jennifer

AU - Healy, Claire

AU - Hegarty, Ryan

AU - Honan, Tracey

AU - Horn, Andrea

AU - Houde, Nathan

AU - Hughes, Leanne

AU - Hunnicutt, Leigh

AU - Husby, M

AU - Jester, Benjamin

AU - Jones, Charlien

AU - Kamat, Asha

AU - Kanga, Ben

AU - Kells, Cristyn

AU - Khazanovich, Dmitry

AU - Kieu, Alix Chinh

AU - Kisner, Peter

AU - Kumar, Mayank

AU - Lance, Krista

AU - Landers, Thomas

AU - Lara, Marcia

AU - Lee, William

AU - Leger, Jean-Pierre

AU - Lennon, Niall

AU - Leuper, Lisa

AU - LeVine, Sarah

AU - Liu, Jinlei

AU - Liu, Xiaohong

AU - Lokyitsang, Yeshi

AU - Lokyitsang, Tashi

AU - Lui, Annie

AU - Macdonald, Jan

AU - Major, John

AU - Marabella, Richard

AU - Maru, Kebede

AU - Matthews, Charles

AU - McDonough, Susan

AU - Mehta, Teena

AU - Meldrim, James

AU - Melnikov, Alexandre

AU - Meneus, Louis

AU - Mihalev, Atanas

AU - Mihova, Tanya

AU - Miller, Karen

AU - Mittelman, Rachel

AU - Mlenga, Valentine

AU - Mulrain, Leonidas

AU - Munson, Glen

AU - Navidi, Adam

AU - Naylor, Jerome

AU - Nguyen, Tuyen

AU - Nguyen, Nga

AU - Nguyen, Cindy

AU - Nguyen, Thu

AU - Nicol, Robert

AU - Norbu, Nyima

AU - Norbu, Choe

AU - Novod, Nathaniel

AU - Nyima, Tenchoe

AU - Olandt, Peter

AU - O'Neill, Barry

AU - O'Neill, Keith

AU - Osman, Sahal

AU - Oyono, Lucien

AU - Patti, Christopher

AU - Perrin, Danielle

AU - Phunkhang, Pema

AU - Pierre, Fritz

AU - Priest, Margaret

AU - Rachupka, Anthony

AU - Raghuraman, Sujaa

AU - Rameau, Rayale

AU - Ray, Verneda

AU - Raymond, Christina

AU - Rege, Filip

AU - Rise, Cecil

AU - Rogers, Julie

AU - Rogov, Peter

AU - Sahalie, Julie

AU - Settipalli, Sampath

AU - Sharpe, Theodore

AU - Shea, Terrance

AU - Sheehan, Mechele

AU - Sherpa, Ngawang

AU - Shi, Jianying

AU - Shih, Diana

AU - Sloan, Jessie

AU - Smith, Cherylyn

AU - Sparrow, Todd

AU - Stalker, John

AU - Stange-Thomann, Nicole

AU - Stavropoulos, Sharon

AU - Stone, Catherine

AU - Stone, Sabrina

AU - Sykes, Sean

AU - Tchuinga, Pierre

AU - Tenzing, Pema

AU - Tesfaye, Senait

AU - Thoulutsang, Dawa

AU - Thoulutsang, Yama

AU - Topham, Kerri

AU - Topping, Ira

AU - Tsamla, Tsamla

AU - Vassiliev, Helen

AU - Venkataraman, Vijay

AU - Vo, Andy

AU - Wangchuk, Tsering

AU - Wangdi, Tsering

AU - Weiand, Michael

AU - Wilkinson, Jane

AU - Wilson, Adam

AU - Yadav, Shailendra

AU - Yang, Shuli

AU - Yang, Xiaoping

AU - Young, Geneva

AU - Yu, Qing

AU - Zainoun, Joanne

AU - Zembek, Lisa

AU - Zimmer, Andrew

AU - Lander, Eric S

PY - 2005/12/8

Y1 - 2005/12/8

N2 - Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

AB - Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

KW - Animals

KW - Conserved Sequence

KW - Dog Diseases

KW - Dogs

KW - Evolution, Molecular

KW - Female

KW - Genome

KW - Genomics

KW - Haplotypes

KW - Humans

KW - Hybridization, Genetic

KW - Male

KW - Mice

KW - Mutagenesis

KW - Polymorphism, Single Nucleotide

KW - Rats

KW - Short Interspersed Nucleotide Elements

KW - Synteny

U2 - 10.1038/nature04338

DO - 10.1038/nature04338

M3 - Article

C2 - 16341006

SN - 0028-0836

VL - 438

SP - 803

EP - 819

JO - Nature

JF - Nature

IS - 7069

ER -

Genome sequence, comparative analysis and haplotype structure of the domestic dog

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