Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

Claudia Manzoni; Demis a. Kia; Raffaele Ferrari; Ganna Leonenko; Beatrice Costa; Valentina Saba; Edwin Jabbari; Manuela mx. Tan; Diego Albani; Victoria Alvarez; Ignacio Alvarez; Ole a. Andreassen; Antonella Angiolillo; Andrea Arighi; Matt Baker; Luisa Benussi; Valentina Bessi; Giuliano Binetti; Daniel j. Blackburn; Merce Boada; Bradley f. Boeve; Sergi Borrego-Ecija; Barbara Borroni; Geir Bråthen; William s. Brooks; Amalia c. Bruni; Paola Caroppo; Sara Bandres-Ciga; Jordi Clarimon; Rosanna Colao; Carlos Cruchaga; Adrian Danek; Sterre cm. De boer; Itziar De rojas; Alfonso Di costanzo; Dennis w. Dickson; Janine Diehl-Schmid; Carol Dobson-Stone; Oriol Dols-Icardo; Aldo Donizetti; Elise Dopper; Elisabetta Durante; Camilla Ferrari; Gianluigi Forloni; Francesca Frangipane; Laura Fratiglioni; Milica g. Kramberger; Daniela Galimberti; Maurizio Gallucci; Pablo García-González; Roberta Ghidoni; Giorgio Giaccone; Caroline Graff; Neill r. Graff-Radford; Jordan Grafman; Glenda m. Halliday; Dena g. Hernandez; Lena e. Hjermind; John r. Hodges; Guy Holloway; Edward d. Huey; Ignacio Illán-Gala; Keith a. Josephs; David s. Knopman; Mark Kristiansen; John b. Kwok; Isabelle Leber; Hampton l. Leonard; Ilenia Libri; Alberto Lleo; Ian r. Mackenzie; Gaganjit k. Madhan; Raffaele Maletta; Marta Marquié; Ales Maver; Manuel Menendez-Gonzalez; Graziella Milan; Bruce l. Miller; Christopher m. Morris; Huw r. Morris; Benedetta Nacmias; Judith Newton; Jørgen e. Nielsen; Christer Nilsson; Valeria Novelli; Alessandro Padovani; Suvankar Pal; Florence Pasquier; Pau Pastor; Robert Perneczky; Borut Peterlin; Ronald c. Petersen; Olivier Piguet; Yolande al. Pijnenburg; Annibale a. Puca; Rosa Rademakers; Innocenzo Rainero; Lianne m. Reus; Anna mt. Richardson; Matthias Riemenschneider; Ekaterina Rogaeva; Boris Rogelj; Sara Rollinson; Howard Rosen; Giacomina Rossi; James b. Rowe; Elisa Rubino; Agustin Ruiz; Erika Salvi; Raquel Sanchez-Valle; Sigrid botne Sando; Alexander f. Santillo; Jennifer a. Saxon; Johannes cm. Schlachetzki; Sonja w. Scholz; Harro Seelaar; William w. Seeley; Maria Serpente; Sandro Sorbi; Sabrina Sordon; Peter St george-Hyslop; Jennifer c. Thompson; Christine Van broeckhoven; Vivianna m. Van deerlin; Sven j. Van der lee; John Van swieten; Fabrizio Tagliavini; Julie Van der zee; Arianna Veronesi; Emilia Vitale; Maria landqvist Waldo; Jennifer s. Yokoyama; Mike a. Nalls; Parastoo Momeni; Andrew b. Singleton; John Hardy; Valentina Escott-Price

doi:10.1016/j.ajhg.2024.05.017

Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

Claudia Manzoni^*, Demis a. Kia, Raffaele Ferrari, Ganna Leonenko, Beatrice Costa, Valentina Saba, Edwin Jabbari, Manuela mx. Tan, Diego Albani, Victoria Alvarez, Ignacio Alvarez, Ole a. Andreassen, Antonella Angiolillo, Andrea Arighi, Matt Baker, Luisa Benussi, Valentina Bessi, Giuliano Binetti, Daniel j. Blackburn, Merce BoadaBradley f. Boeve, Sergi Borrego-Ecija, Barbara Borroni, Geir Bråthen, William s. Brooks, Amalia c. Bruni, Paola Caroppo, Sara Bandres-Ciga, Jordi Clarimon, Rosanna Colao, Carlos Cruchaga, Adrian Danek, Sterre cm. De boer, Itziar De rojas, Alfonso Di costanzo, Dennis w. Dickson, Janine Diehl-Schmid, Carol Dobson-Stone, Oriol Dols-Icardo, Aldo Donizetti, Elise Dopper, Elisabetta Durante, Camilla Ferrari, Gianluigi Forloni, Francesca Frangipane, Laura Fratiglioni, Milica g. Kramberger, Daniela Galimberti, Maurizio Gallucci, Pablo García-González, Roberta Ghidoni, Giorgio Giaccone, Caroline Graff, Neill r. Graff-Radford, Jordan Grafman, Glenda m. Halliday, Dena g. Hernandez, Lena e. Hjermind, John r. Hodges, Guy Holloway, Edward d. Huey, Ignacio Illán-Gala, Keith a. Josephs, David s. Knopman, Mark Kristiansen, John b. Kwok, Isabelle Leber, Hampton l. Leonard, Ilenia Libri, Alberto Lleo, Ian r. Mackenzie, Gaganjit k. Madhan, Raffaele Maletta, Marta Marquié, Ales Maver, Manuel Menendez-Gonzalez, Graziella Milan, Bruce l. Miller, Christopher m. Morris, Huw r. Morris, Benedetta Nacmias, Judith Newton, Jørgen e. Nielsen, Christer Nilsson, Valeria Novelli, Alessandro Padovani, Suvankar Pal, Florence Pasquier, Pau Pastor, Robert Perneczky, Borut Peterlin, Ronald c. Petersen, Olivier Piguet, Yolande al. Pijnenburg, Annibale a. Puca, Rosa Rademakers, Innocenzo Rainero, Lianne m. Reus, Anna mt. Richardson, Matthias Riemenschneider, Ekaterina Rogaeva, Boris Rogelj, Sara Rollinson, Howard Rosen, Giacomina Rossi, James b. Rowe, Elisa Rubino, Agustin Ruiz, Erika Salvi, Raquel Sanchez-Valle, Sigrid botne Sando, Alexander f. Santillo, Jennifer a. Saxon, Johannes cm. Schlachetzki, Sonja w. Scholz, Harro Seelaar, William w. Seeley, Maria Serpente, Sandro Sorbi, Sabrina Sordon, Peter St george-Hyslop, Jennifer c. Thompson, Christine Van broeckhoven, Vivianna m. Van deerlin, Sven j. Van der lee, John Van swieten, Fabrizio Tagliavini, Julie Van der zee, Arianna Veronesi, Emilia Vitale, Maria landqvist Waldo, Jennifer s. Yokoyama, Mike a. Nalls, Parastoo Momeni, Andrew b. Singleton, John Hardy, Valentina Escott-Price^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	The American Journal of Human Genetics
DOIs	https://doi.org/10.1016/j.ajhg.2024.05.017
Publication status	Published - 17 Jun 2024

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Cite this

Manzoni, C., Kia, D. A., Ferrari, R., Leonenko, G., Costa, B., Saba, V., Jabbari, E., Tan, M. M., Albani, D., Alvarez, V., Alvarez, I., Andreassen, O. A., Angiolillo, A., Arighi, A., Baker, M., Benussi, L., Bessi, V., Binetti, G., Blackburn, D. J., ... Escott-Price, V. (2024). Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia. The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2024.05.017

@article{4adcb7b8768a487db2a152eb31a59b44,

title = "Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia",

author = "Claudia Manzoni and Kia, \{Demis a.\} and Raffaele Ferrari and Ganna Leonenko and Beatrice Costa and Valentina Saba and Edwin Jabbari and Tan, \{Manuela mx.\} and Diego Albani and Victoria Alvarez and Ignacio Alvarez and Andreassen, \{Ole a.\} and Antonella Angiolillo and Andrea Arighi and Matt Baker and Luisa Benussi and Valentina Bessi and Giuliano Binetti and Blackburn, \{Daniel j.\} and Merce Boada and Boeve, \{Bradley f.\} and Sergi Borrego-Ecija and Barbara Borroni and Geir Br{\aa}then and Brooks, \{William s.\} and Bruni, \{Amalia c.\} and Paola Caroppo and Sara Bandres-Ciga and Jordi Clarimon and Rosanna Colao and Carlos Cruchaga and Adrian Danek and \{De boer\}, \{Sterre cm.\} and \{De rojas\}, Itziar and \{Di costanzo\}, Alfonso and Dickson, \{Dennis w.\} and Janine Diehl-Schmid and Carol Dobson-Stone and Oriol Dols-Icardo and Aldo Donizetti and Elise Dopper and Elisabetta Durante and Camilla Ferrari and Gianluigi Forloni and Francesca Frangipane and Laura Fratiglioni and Kramberger, \{Milica g.\} and Daniela Galimberti and Maurizio Gallucci and Pablo Garc{\'i}a-Gonz{\'a}lez and Roberta Ghidoni and Giorgio Giaccone and Caroline Graff and Graff-Radford, \{Neill r.\} and Jordan Grafman and Halliday, \{Glenda m.\} and Hernandez, \{Dena g.\} and Hjermind, \{Lena e.\} and Hodges, \{John r.\} and Guy Holloway and Huey, \{Edward d.\} and Ignacio Ill{\'a}n-Gala and Josephs, \{Keith a.\} and Knopman, \{David s.\} and Mark Kristiansen and Kwok, \{John b.\} and Isabelle Leber and Leonard, \{Hampton l.\} and Ilenia Libri and Alberto Lleo and Mackenzie, \{Ian r.\} and Madhan, \{Gaganjit k.\} and Raffaele Maletta and Marta Marqui{\'e} and Ales Maver and Manuel Menendez-Gonzalez and Graziella Milan and Miller, \{Bruce l.\} and Morris, \{Christopher m.\} and Morris, \{Huw r.\} and Benedetta Nacmias and Judith Newton and Nielsen, \{J{\o}rgen e.\} and Christer Nilsson and Valeria Novelli and Alessandro Padovani and Suvankar Pal and Florence Pasquier and Pau Pastor and Robert Perneczky and Borut Peterlin and Petersen, \{Ronald c.\} and Olivier Piguet and Pijnenburg, \{Yolande al.\} and Puca, \{Annibale a.\} and Rosa Rademakers and Innocenzo Rainero and Reus, \{Lianne m.\} and Richardson, \{Anna mt.\} and Matthias Riemenschneider and Ekaterina Rogaeva and Boris Rogelj and Sara Rollinson and Howard Rosen and Giacomina Rossi and Rowe, \{James b.\} and Elisa Rubino and Agustin Ruiz and Erika Salvi and Raquel Sanchez-Valle and Sando, \{Sigrid botne\} and Santillo, \{Alexander f.\} and Saxon, \{Jennifer a.\} and Schlachetzki, \{Johannes cm.\} and Scholz, \{Sonja w.\} and Harro Seelaar and Seeley, \{William w.\} and Maria Serpente and Sandro Sorbi and Sabrina Sordon and \{St george-Hyslop\}, Peter and Thompson, \{Jennifer c.\} and \{Van broeckhoven\}, Christine and \{Van deerlin\}, \{Vivianna m.\} and \{Van der lee\}, \{Sven j.\} and \{Van swieten\}, John and Fabrizio Tagliavini and \{Van der zee\}, Julie and Arianna Veronesi and Emilia Vitale and Waldo, \{Maria landqvist\} and Yokoyama, \{Jennifer s.\} and Nalls, \{Mike a.\} and Parastoo Momeni and Singleton, \{Andrew b.\} and John Hardy and Valentina Escott-Price",

year = "2024",

month = jun,

day = "17",

doi = "10.1016/j.ajhg.2024.05.017",

language = "English",

journal = "The American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

}

Manzoni, C, Kia, DA, Ferrari, R, Leonenko, G, Costa, B, Saba, V, Jabbari, E, Tan, MM, Albani, D, Alvarez, V, Alvarez, I, Andreassen, OA, Angiolillo, A, Arighi, A, Baker, M, Benussi, L, Bessi, V, Binetti, G, Blackburn, DJ, Boada, M, Boeve, BF, Borrego-Ecija, S, Borroni, B, Bråthen, G, Brooks, WS, Bruni, AC, Caroppo, P, Bandres-Ciga, S, Clarimon, J, Colao, R, Cruchaga, C, Danek, A, De boer, SC, De rojas, I, Di costanzo, A, Dickson, DW, Diehl-Schmid, J, Dobson-Stone, C, Dols-Icardo, O, Donizetti, A, Dopper, E, Durante, E, Ferrari, C, Forloni, G, Frangipane, F, Fratiglioni, L, Kramberger, MG, Galimberti, D, Gallucci, M, García-González, P, Ghidoni, R, Giaccone, G, Graff, C, Graff-Radford, NR, Grafman, J, Halliday, GM, Hernandez, DG, Hjermind, LE, Hodges, JR, Holloway, G, Huey, ED, Illán-Gala, I, Josephs, KA, Knopman, DS, Kristiansen, M, Kwok, JB, Leber, I, Leonard, HL, Libri, I, Lleo, A, Mackenzie, IR, Madhan, GK, Maletta, R, Marquié, M, Maver, A, Menendez-Gonzalez, M, Milan, G, Miller, BL, Morris, CM, Morris, HR, Nacmias, B, Newton, J, Nielsen, JE, Nilsson, C, Novelli, V, Padovani, A, Pal, S, Pasquier, F, Pastor, P, Perneczky, R, Peterlin, B, Petersen, RC, Piguet, O, Pijnenburg, YA, Puca, AA, Rademakers, R, Rainero, I, Reus, LM, Richardson, AM, Riemenschneider, M, Rogaeva, E, Rogelj, B, Rollinson, S, Rosen, H, Rossi, G, Rowe, JB, Rubino, E, Ruiz, A, Salvi, E, Sanchez-Valle, R, Sando, SB, Santillo, AF, Saxon, JA, Schlachetzki, JC, Scholz, SW, Seelaar, H, Seeley, WW, Serpente, M, Sorbi, S, Sordon, S, St george-Hyslop, P, Thompson, JC, Van broeckhoven, C, Van deerlin, VM, Van der lee, SJ, Van swieten, J, Tagliavini, F, Van der zee, J, Veronesi, A, Vitale, E, Waldo, ML, Yokoyama, JS, Nalls, MA, Momeni, P, Singleton, AB, Hardy, J & Escott-Price, V 2024, 'Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia', The American Journal of Human Genetics. https://doi.org/10.1016/j.ajhg.2024.05.017

TY - JOUR

T1 - Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia

AU - Manzoni, Claudia

AU - Kia, Demis a.

AU - Ferrari, Raffaele

AU - Leonenko, Ganna

AU - Costa, Beatrice

AU - Saba, Valentina

AU - Jabbari, Edwin

AU - Tan, Manuela mx.

AU - Albani, Diego

AU - Alvarez, Victoria

AU - Alvarez, Ignacio

AU - Andreassen, Ole a.

AU - Angiolillo, Antonella

AU - Arighi, Andrea

AU - Baker, Matt

AU - Benussi, Luisa

AU - Bessi, Valentina

AU - Binetti, Giuliano

AU - Blackburn, Daniel j.

AU - Boada, Merce

AU - Boeve, Bradley f.

AU - Borrego-Ecija, Sergi

AU - Borroni, Barbara

AU - Bråthen, Geir

AU - Brooks, William s.

AU - Bruni, Amalia c.

AU - Caroppo, Paola

AU - Bandres-Ciga, Sara

AU - Clarimon, Jordi

AU - Colao, Rosanna

AU - Cruchaga, Carlos

AU - Danek, Adrian

AU - De boer, Sterre cm.

AU - De rojas, Itziar

AU - Di costanzo, Alfonso

AU - Dickson, Dennis w.

AU - Diehl-Schmid, Janine

AU - Dobson-Stone, Carol

AU - Dols-Icardo, Oriol

AU - Donizetti, Aldo

AU - Dopper, Elise

AU - Durante, Elisabetta

AU - Ferrari, Camilla

AU - Forloni, Gianluigi

AU - Frangipane, Francesca

AU - Fratiglioni, Laura

AU - Kramberger, Milica g.

AU - Galimberti, Daniela

AU - Gallucci, Maurizio

AU - García-González, Pablo

AU - Ghidoni, Roberta

AU - Giaccone, Giorgio

AU - Graff, Caroline

AU - Graff-Radford, Neill r.

AU - Grafman, Jordan

AU - Halliday, Glenda m.

AU - Hernandez, Dena g.

AU - Hjermind, Lena e.

AU - Hodges, John r.

AU - Holloway, Guy

AU - Huey, Edward d.

AU - Illán-Gala, Ignacio

AU - Josephs, Keith a.

AU - Knopman, David s.

AU - Kristiansen, Mark

AU - Kwok, John b.

AU - Leber, Isabelle

AU - Leonard, Hampton l.

AU - Libri, Ilenia

AU - Lleo, Alberto

AU - Mackenzie, Ian r.

AU - Madhan, Gaganjit k.

AU - Maletta, Raffaele

AU - Marquié, Marta

AU - Maver, Ales

AU - Menendez-Gonzalez, Manuel

AU - Milan, Graziella

AU - Miller, Bruce l.

AU - Morris, Christopher m.

AU - Morris, Huw r.

AU - Nacmias, Benedetta

AU - Newton, Judith

AU - Nielsen, Jørgen e.

AU - Nilsson, Christer

AU - Novelli, Valeria

AU - Padovani, Alessandro

AU - Pal, Suvankar

AU - Pasquier, Florence

AU - Pastor, Pau

AU - Perneczky, Robert

AU - Peterlin, Borut

AU - Petersen, Ronald c.

AU - Piguet, Olivier

AU - Pijnenburg, Yolande al.

AU - Puca, Annibale a.

AU - Rademakers, Rosa

AU - Rainero, Innocenzo

AU - Reus, Lianne m.

AU - Richardson, Anna mt.

AU - Riemenschneider, Matthias

AU - Rogaeva, Ekaterina

AU - Rogelj, Boris

AU - Rollinson, Sara

AU - Rosen, Howard

AU - Rossi, Giacomina

AU - Rowe, James b.

AU - Rubino, Elisa

AU - Ruiz, Agustin

AU - Salvi, Erika

AU - Sanchez-Valle, Raquel

AU - Sando, Sigrid botne

AU - Santillo, Alexander f.

AU - Saxon, Jennifer a.

AU - Schlachetzki, Johannes cm.

AU - Scholz, Sonja w.

AU - Seelaar, Harro

AU - Seeley, William w.

AU - Serpente, Maria

AU - Sorbi, Sandro

AU - Sordon, Sabrina

AU - St george-Hyslop, Peter

AU - Thompson, Jennifer c.

AU - Van broeckhoven, Christine

AU - Van deerlin, Vivianna m.

AU - Van der lee, Sven j.

AU - Van swieten, John

AU - Tagliavini, Fabrizio

AU - Van der zee, Julie

AU - Veronesi, Arianna

AU - Vitale, Emilia

AU - Waldo, Maria landqvist

AU - Yokoyama, Jennifer s.

AU - Nalls, Mike a.

AU - Momeni, Parastoo

AU - Singleton, Andrew b.

AU - Hardy, John

AU - Escott-Price, Valentina

PY - 2024/6/17

Y1 - 2024/6/17

U2 - 10.1016/j.ajhg.2024.05.017

DO - 10.1016/j.ajhg.2024.05.017

M3 - Article

SN - 0002-9297

JO - The American Journal of Human Genetics

JF - The American Journal of Human Genetics

ER -