Genome-wide analysis of mitral valve disease in Cavalier King Charles Spaniels

A.T. French, Rob Ogden, C. Eland, G. Hemani, R. Pong-Wong, B.M. Corcoran, K.M. Summers

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The Cavalier King Charles Spaniel (CKCS) is prone to severe early onset mitral valve disease. In this study, 36 purebred CKCS dogs were evaluated for mitral valve murmur and divided into early and late onset groups. A genome-wide genetic approach was used to assess whether the condition is determined by a small number of genetic factors. There were no regions of highly discrepant homo/heterozygosity in the two groups. Similarly, there was no evidence for loci associated with mitral valve murmur in a genome-wide association study. This analysis suggests that familial occurrence of mitral valve murmur in the CKCS breed is not due to a single major gene effect, indicating that breeding strategies to eliminate the disease cannot be based on genotype information at this time.
Original languageEnglish
Pages (from-to)283-286
JournalThe Veterinary Journal
Issue number1
Publication statusPublished - 2012

Keywords / Materials (for Non-textual outputs)

  • Mitral valve disease Cavalier King Charles Spaniel Genome-wide association Homozygosity mapping DNA analysis


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