Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Wouter Van Rheenen; Aleksey Shatunov; Annelot M Dekker; Russell L Mclaughlin; Frank P Diekstra; Sara L Pulit; Rick A A Van Der Spek; Urmo Võsa; Simone De Jong; Matthew R Robinson; Jian Yang; Isabella Fogh; Perry Tc Van Doormaal; Gijs H P Tazelaar; Max Koppers; Anna M Blokhuis; William Sproviero; Ashley R Jones; Kevin P Kenna; Kristel R Van Eijk; Oliver Harschnitz; Raymond D Schellevis; William J Brands; Jelena Medic; Androniki Menelaou; Alice Vajda; Nicola Ticozzi; Kuang Lin; Boris Rogelj; Katarina Vrabec; Metka Ravnik-glavač; Blaž Koritnik; Janez Zidar; Lea Leonardis; Leja Dolenc Grošelj; Stéphanie Millecamps; François Salachas; Vincent Meininger; Mamede De Carvalho; Susana Pinto; Jesus S Mora; Ricardo Rojas-garcía; Meraida Polak; Siddharthan Chandran; Shuna Colville; Robert Swingler; Karen E Morrison; Pamela J Shaw; John Hardy; Richard W Orrell; Alan Pittman; Katie Sidle; Pietro Fratta; Andrea Malaspina; Simon Topp; Susanne Petri; Susanne Abdulla; Carsten Drepper; Michael Sendtner; Thomas Meyer; Roel A Ophoff; Kim A Staats; Martina Wiedau-pazos; Catherine Lomen-hoerth; Vivianna M Van Deerlin; John Q Trojanowski; Lauren Elman; Leo Mccluskey; A Nazli Basak; Ceren Tunca; Hamid Hamzeiy; Yesim Parman; Thomas Meitinger; Peter Lichtner; Milena Radivojkov-blagojevic; Christian R Andres; Cindy Maurel; Gilbert Bensimon; Bernhard Landwehrmeyer; Alexis Brice; Christine A M Payan; Safaa Saker-delye; Alexandra Dürr; Nicholas W Wood; Lukas Tittmann; Wolfgang Lieb; Andre Franke; Marcella Rietschel; Sven Cichon; Markus M Nöthen; Philippe Amouyel; Christophe Tzourio; Jean-françois Dartigues; Andre G Uitterlinden; Fernando Rivadeneira; Karol Estrada; Albert Hofman; Charles Curtis; Hylke M Blauw; Anneke J Van Der Kooi; Marianne De Visser; An Goris; Markus Weber; Christopher E Shaw; Bradley N Smith; Orietta Pansarasa; Cristina Cereda; Roberto Del Bo; Giacomo P Comi; Sandra D'alfonso; Cinzia Bertolin; Gianni Sorarù; Letizia Mazzini; Viviana Pensato; Cinzia Gellera; Cinzia Tiloca; Antonia Ratti; Andrea Calvo; Cristina Moglia; Maura Brunetti; Simona Arcuti; Rosa Capozzo; Chiara Zecca; Christian Lunetta; Silvana Penco; Nilo Riva; Alessandro Padovani; Massimiliano Filosto; Bernard Muller; Robbert Jan Stuit; Ian Blair; Katharine Zhang; Emily P Mccann; Jennifer A Fifita; Garth A Nicholson; Dominic B Rowe; Roger Pamphlett; Matthew C Kiernan; Julian Grosskreutz; Otto W Witte; Thomas Ringer; Tino Prell; Beatrice Stubendorff; Ingo Kurth; Christian A Hübner; P Nigel Leigh; Federico Casale; Adriano Chio; Ettore Beghi; Elisabetta Pupillo; Rosanna Tortelli; Giancarlo Logroscino; John Powell; Albert C Ludolph; Jochen H Weishaupt; Wim Robberecht; Philip Van Damme; Lude Franke; Tune H Pers; Robert H Brown; Jonathan D Glass; John E Landers; Orla Hardiman; Peter M Andersen; Philippe Corcia; Patrick Vourc'h; Vincenzo Silani; Naomi R Wray; Peter M Visscher; Paul I W De Bakker; Michael A Van Es; R Jeroen Pasterkamp; Cathryn M Lewis; Gerome Breen; Ammar Al-chalabi; Leonard H Van Den Berg; Jan H Veldink

doi:10.1038/ng.3622

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

Wouter Van Rheenen, Aleksey Shatunov, Annelot M Dekker, Russell L Mclaughlin, Frank P Diekstra, Sara L Pulit, Rick A A Van Der Spek, Urmo Võsa, Simone De Jong, Matthew R Robinson, Jian Yang, Isabella Fogh, Perry Tc Van Doormaal, Gijs H P Tazelaar, Max Koppers, Anna M Blokhuis, William Sproviero, Ashley R Jones, Kevin P Kenna, Kristel R Van EijkOliver Harschnitz, Raymond D Schellevis, William J Brands, Jelena Medic, Androniki Menelaou, Alice Vajda, Nicola Ticozzi, Kuang Lin, Boris Rogelj, Katarina Vrabec, Metka Ravnik-glavač, Blaž Koritnik, Janez Zidar, Lea Leonardis, Leja Dolenc Grošelj, Stéphanie Millecamps, François Salachas, Vincent Meininger, Mamede De Carvalho, Susana Pinto, Jesus S Mora, Ricardo Rojas-garcía, Meraida Polak, Siddharthan Chandran, Shuna Colville, Robert Swingler, Karen E Morrison, Pamela J Shaw, John Hardy, Richard W Orrell, Alan Pittman, Katie Sidle, Pietro Fratta, Andrea Malaspina, Simon Topp, Susanne Petri, Susanne Abdulla, Carsten Drepper, Michael Sendtner, Thomas Meyer, Roel A Ophoff, Kim A Staats, Martina Wiedau-pazos, Catherine Lomen-hoerth, Vivianna M Van Deerlin, John Q Trojanowski, Lauren Elman, Leo Mccluskey, A Nazli Basak, Ceren Tunca, Hamid Hamzeiy, Yesim Parman, Thomas Meitinger, Peter Lichtner, Milena Radivojkov-blagojevic, Christian R Andres, Cindy Maurel, Gilbert Bensimon, Bernhard Landwehrmeyer, Alexis Brice, Christine A M Payan, Safaa Saker-delye, Alexandra Dürr, Nicholas W Wood, Lukas Tittmann, Wolfgang Lieb, Andre Franke, Marcella Rietschel, Sven Cichon, Markus M Nöthen, Philippe Amouyel, Christophe Tzourio, Jean-françois Dartigues, Andre G Uitterlinden, Fernando Rivadeneira, Karol Estrada, Albert Hofman, Charles Curtis, Hylke M Blauw, Anneke J Van Der Kooi, Marianne De Visser, An Goris, Markus Weber, Christopher E Shaw, Bradley N Smith, Orietta Pansarasa, Cristina Cereda, Roberto Del Bo, Giacomo P Comi, Sandra D'alfonso, Cinzia Bertolin, Gianni Sorarù, Letizia Mazzini, Viviana Pensato, Cinzia Gellera, Cinzia Tiloca, Antonia Ratti, Andrea Calvo, Cristina Moglia, Maura Brunetti, Simona Arcuti, Rosa Capozzo, Chiara Zecca, Christian Lunetta, Silvana Penco, Nilo Riva, Alessandro Padovani, Massimiliano Filosto, Bernard Muller, Robbert Jan Stuit, Ian Blair, Katharine Zhang, Emily P Mccann, Jennifer A Fifita, Garth A Nicholson, Dominic B Rowe, Roger Pamphlett, Matthew C Kiernan, Julian Grosskreutz, Otto W Witte, Thomas Ringer, Tino Prell, Beatrice Stubendorff, Ingo Kurth, Christian A Hübner, P Nigel Leigh, Federico Casale, Adriano Chio, Ettore Beghi, Elisabetta Pupillo, Rosanna Tortelli, Giancarlo Logroscino, John Powell, Albert C Ludolph, Jochen H Weishaupt, Wim Robberecht, Philip Van Damme, Lude Franke, Tune H Pers, Robert H Brown, Jonathan D Glass, John E Landers, Orla Hardiman, Peter M Andersen, Philippe Corcia, Patrick Vourc'h, Vincenzo Silani, Naomi R Wray, Peter M Visscher, Paul I W De Bakker, Michael A Van Es, R Jeroen Pasterkamp, Cathryn M Lewis, Gerome Breen, Ammar Al-chalabi, Leonard H Van Den Berg, Jan H Veldink

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Nature Genetics
DOIs	https://doi.org/10.1038/ng.3622
Publication status	Published - 25 Jul 2016

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10.1038/ng.3622

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
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Cite this

Van Rheenen, W., Shatunov, A., Dekker, A. M., Mclaughlin, R. L., Diekstra, F. P., Pulit, S. L., Van Der Spek, R. A. A., Võsa, U., De Jong, S., Robinson, M. R., Yang, J., Fogh, I., Van Doormaal, P. T., Tazelaar, G. H. P., Koppers, M., Blokhuis, A. M., Sproviero, W., Jones, A. R., Kenna, K. P., ... Veldink, J. H. (2016). Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis. Nature Genetics. https://doi.org/10.1038/ng.3622

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doi = "10.1038/ng.3622",

language = "English",

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publisher = "Nature Publishing Group",

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Van Rheenen, W, Shatunov, A, Dekker, AM, Mclaughlin, RL, Diekstra, FP, Pulit, SL, Van Der Spek, RAA, Võsa, U, De Jong, S, Robinson, MR, Yang, J, Fogh, I, Van Doormaal, PT, Tazelaar, GHP, Koppers, M, Blokhuis, AM, Sproviero, W, Jones, AR, Kenna, KP, Van Eijk, KR, Harschnitz, O, Schellevis, RD, Brands, WJ, Medic, J, Menelaou, A, Vajda, A, Ticozzi, N, Lin, K, Rogelj, B, Vrabec, K, Ravnik-glavač, M, Koritnik, B, Zidar, J, Leonardis, L, Grošelj, LD, Millecamps, S, Salachas, F, Meininger, V, De Carvalho, M, Pinto, S, Mora, JS, Rojas-garcía, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Topp, S, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Ophoff, RA, Staats, KA, Wiedau-pazos, M, Lomen-hoerth, C, Van Deerlin, VM, Trojanowski, JQ, Elman, L, Mccluskey, L, Basak, AN, Tunca, C, Hamzeiy, H, Parman, Y, Meitinger, T, Lichtner, P, Radivojkov-blagojevic, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-delye, S, Dürr, A, Wood, NW, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nöthen, MM, Amouyel, P, Tzourio, C, Dartigues, J, Uitterlinden, AG, Rivadeneira, F, Estrada, K, Hofman, A, Curtis, C, Blauw, HM, Van Der Kooi, AJ, De Visser, M, Goris, A, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Del Bo, R, Comi, GP, D'alfonso, S, Bertolin, C, Sorarù, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Muller, B, Stuit, RJ, Blair, I, Zhang, K, Mccann, EP, Fifita, JA, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Grosskreutz, J, Witte, OW, Ringer, T, Prell, T, Stubendorff, B, Kurth, I, Hübner, CA, Leigh, PN, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, Van Damme, P, Franke, L, Pers, TH, Brown, RH, Glass, JD, Landers, JE, Hardiman, O, Andersen, PM, Corcia, P, Vourc'h, P, Silani, V, Wray, NR, Visscher, PM, De Bakker, PIW, Van Es, MA, Pasterkamp, RJ, Lewis, CM, Breen, G, Al-chalabi, A, Van Den Berg, LH & Veldink, JH 2016, 'Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis', Nature Genetics. https://doi.org/10.1038/ng.3622

TY - JOUR

T1 - Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

AU - Van Rheenen, Wouter

AU - Shatunov, Aleksey

AU - Dekker, Annelot M

AU - Mclaughlin, Russell L

AU - Diekstra, Frank P

AU - Pulit, Sara L

AU - Van Der Spek, Rick A A

AU - Võsa, Urmo

AU - De Jong, Simone

AU - Robinson, Matthew R

AU - Yang, Jian

AU - Fogh, Isabella

AU - Van Doormaal, Perry Tc

AU - Tazelaar, Gijs H P

AU - Koppers, Max

AU - Blokhuis, Anna M

AU - Sproviero, William

AU - Jones, Ashley R

AU - Kenna, Kevin P

AU - Van Eijk, Kristel R

AU - Harschnitz, Oliver

AU - Schellevis, Raymond D

AU - Brands, William J

AU - Medic, Jelena

AU - Menelaou, Androniki

AU - Vajda, Alice

AU - Ticozzi, Nicola

AU - Lin, Kuang

AU - Rogelj, Boris

AU - Vrabec, Katarina

AU - Ravnik-glavač, Metka

AU - Koritnik, Blaž

AU - Zidar, Janez

AU - Leonardis, Lea

AU - Grošelj, Leja Dolenc

AU - Millecamps, Stéphanie

AU - Salachas, François

AU - Meininger, Vincent

AU - De Carvalho, Mamede

AU - Pinto, Susana

AU - Mora, Jesus S

AU - Rojas-garcía, Ricardo

AU - Polak, Meraida

AU - Chandran, Siddharthan

AU - Colville, Shuna

AU - Swingler, Robert

AU - Morrison, Karen E

AU - Shaw, Pamela J

AU - Hardy, John

AU - Orrell, Richard W

AU - Pittman, Alan

AU - Sidle, Katie

AU - Fratta, Pietro

AU - Malaspina, Andrea

AU - Topp, Simon

AU - Petri, Susanne

AU - Abdulla, Susanne

AU - Drepper, Carsten

AU - Sendtner, Michael

AU - Meyer, Thomas

AU - Ophoff, Roel A

AU - Staats, Kim A

AU - Wiedau-pazos, Martina

AU - Lomen-hoerth, Catherine

AU - Van Deerlin, Vivianna M

AU - Trojanowski, John Q

AU - Elman, Lauren

AU - Mccluskey, Leo

AU - Basak, A Nazli

AU - Tunca, Ceren

AU - Hamzeiy, Hamid

AU - Parman, Yesim

AU - Meitinger, Thomas

AU - Lichtner, Peter

AU - Radivojkov-blagojevic, Milena

AU - Andres, Christian R

AU - Maurel, Cindy

AU - Bensimon, Gilbert

AU - Landwehrmeyer, Bernhard

AU - Brice, Alexis

AU - Payan, Christine A M

AU - Saker-delye, Safaa

AU - Dürr, Alexandra

AU - Wood, Nicholas W

AU - Tittmann, Lukas

AU - Lieb, Wolfgang

AU - Franke, Andre

AU - Rietschel, Marcella

AU - Cichon, Sven

AU - Nöthen, Markus M

AU - Amouyel, Philippe

AU - Tzourio, Christophe

AU - Dartigues, Jean-françois

AU - Uitterlinden, Andre G

AU - Rivadeneira, Fernando

AU - Estrada, Karol

AU - Hofman, Albert

AU - Curtis, Charles

AU - Blauw, Hylke M

AU - Van Der Kooi, Anneke J

AU - De Visser, Marianne

AU - Goris, An

AU - Weber, Markus

AU - Shaw, Christopher E

AU - Smith, Bradley N

AU - Pansarasa, Orietta

AU - Cereda, Cristina

AU - Del Bo, Roberto

AU - Comi, Giacomo P

AU - D'alfonso, Sandra

AU - Bertolin, Cinzia

AU - Sorarù, Gianni

AU - Mazzini, Letizia

AU - Pensato, Viviana

AU - Gellera, Cinzia

AU - Tiloca, Cinzia

AU - Ratti, Antonia

AU - Calvo, Andrea

AU - Moglia, Cristina

AU - Brunetti, Maura

AU - Arcuti, Simona

AU - Capozzo, Rosa

AU - Zecca, Chiara

AU - Lunetta, Christian

AU - Penco, Silvana

AU - Riva, Nilo

AU - Padovani, Alessandro

AU - Filosto, Massimiliano

AU - Muller, Bernard

AU - Stuit, Robbert Jan

AU - Blair, Ian

AU - Zhang, Katharine

AU - Mccann, Emily P

AU - Fifita, Jennifer A

AU - Nicholson, Garth A

AU - Rowe, Dominic B

AU - Pamphlett, Roger

AU - Kiernan, Matthew C

AU - Grosskreutz, Julian

AU - Witte, Otto W

AU - Ringer, Thomas

AU - Prell, Tino

AU - Stubendorff, Beatrice

AU - Kurth, Ingo

AU - Hübner, Christian A

AU - Leigh, P Nigel

AU - Casale, Federico

AU - Chio, Adriano

AU - Beghi, Ettore

AU - Pupillo, Elisabetta

AU - Tortelli, Rosanna

AU - Logroscino, Giancarlo

AU - Powell, John

AU - Ludolph, Albert C

AU - Weishaupt, Jochen H

AU - Robberecht, Wim

AU - Van Damme, Philip

AU - Franke, Lude

AU - Pers, Tune H

AU - Brown, Robert H

AU - Glass, Jonathan D

AU - Landers, John E

AU - Hardiman, Orla

AU - Andersen, Peter M

AU - Corcia, Philippe

AU - Vourc'h, Patrick

AU - Silani, Vincenzo

AU - Wray, Naomi R

AU - Visscher, Peter M

AU - De Bakker, Paul I W

AU - Van Es, Michael A

AU - Pasterkamp, R Jeroen

AU - Lewis, Cathryn M

AU - Breen, Gerome

AU - Al-chalabi, Ammar

AU - Van Den Berg, Leonard H

AU - Veldink, Jan H

PY - 2016/7/25

Y1 - 2016/7/25

U2 - 10.1038/ng.3622

DO - 10.1038/ng.3622

M3 - Article

SN - 1061-4036

JO - Nature Genetics

JF - Nature Genetics

ER -