Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

International Lung Cancer Consortium; María Soler Artigas; Daan W Loth; Louise V Wain; Sina A Gharib; Ma'en Obeidat; Wenbo Tang; Guangju Zhai; Jing Hua Zhao; Albert Vernon Smith; Jennifer E Huffman; Eva Albrecht; Catherine M Jackson; David M Evans; Gemma Cadby; Myriam Fornage; Ani Manichaikul; Lorna M Lopez; Toby Johnson; Melinda C Aldrich; Thor Aspelund; Inês Barroso; Harry Campbell; Patricia A Cassano; David J Couper; Gudny Eiriksdottir; Nora Franceschini; Melissa Garcia; Christian Gieger; Gauti Kjartan Gislason; Ivica Grkovic; Christopher J Hammond; Dana B Hancock; Tamara B Harris; Adaikalavan Ramasamy; Susan R Heckbert; Ian J Deary; Sarah E Harris; John Henderson; Michael L Hunter; Shona M Kerr; Andrew Morris; David J Porteous; John M Starr; Igor Rudan; Veronique Vitart; Sarah H Wild; Alan F Wright; Lina Zgaga; James F Wilson; Caroline Hayward

doi:10.1038/ng.941

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

International Lung Cancer Consortium, María Soler Artigas, Daan W Loth, Louise V Wain, Sina A Gharib, Ma'en Obeidat, Wenbo Tang, Guangju Zhai, Jing Hua Zhao, Albert Vernon Smith, Jennifer E Huffman, Eva Albrecht, Catherine M Jackson, David M Evans, Gemma Cadby, Myriam Fornage, Ani Manichaikul, Lorna M Lopez, Toby Johnson, Melinda C AldrichThor Aspelund, Inês Barroso, Harry Campbell, Patricia A Cassano, David J Couper, Gudny Eiriksdottir, Nora Franceschini, Melissa Garcia, Christian Gieger, Gauti Kjartan Gislason, Ivica Grkovic, Christopher J Hammond, Dana B Hancock, Tamara B Harris, Adaikalavan Ramasamy, Susan R Heckbert, Ian J Deary, Sarah E Harris, John Henderson, Michael L Hunter, Shona M Kerr, Andrew Morris, David J Porteous, John M Starr, Igor Rudan, Veronique Vitart, Sarah H Wild, Alan F Wright, Lina Zgaga, James F Wilson, Caroline Hayward

Research output: Contribution to journal › Article › peer-review

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Original language	English
Pages (from-to)	1082-90
Number of pages	9
Journal	Nature Genetics
Volume	43
Issue number	11
DOIs	https://doi.org/10.1038/ng.941
Publication status	Published - Nov 2011

Keywords / Materials (for Non-textual outputs)

OBSTRUCTIVE PULMONARY-DISEASE
GENETIC-VARIATION
BLOOD-PRESSURE
VARIANTS
METAANALYSIS
RISK
PROTEIN
POLYMORPHISMS
POPULATION
EXPRESSION

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10.1038/ng.941

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
© 2011 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Accepted author manuscript, 975 KB

http://www.nature.com/ng/journal/v43/n11/full/ng.941.html

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International Lung Cancer Consortium, Soler Artigas, M., Loth, D. W., Wain, L. V., Gharib, S. A., Obeidat, M., Tang, W., Zhai, G., Zhao, J. H., Smith, A. V., Huffman, J. E., Albrecht, E., Jackson, C. M., Evans, D. M., Cadby, G., Fornage, M., Manichaikul, A., Lopez, L. M., Johnson, T., ... Hayward, C. (2011). Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43(11), 1082-90. https://doi.org/10.1038/ng.941

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title = "Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function",

abstract = "Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.",

keywords = "OBSTRUCTIVE PULMONARY-DISEASE, GENETIC-VARIATION, BLOOD-PRESSURE, VARIANTS, METAANALYSIS, RISK, PROTEIN, POLYMORPHISMS, POPULATION, EXPRESSION",

author = "{International Lung Cancer Consortium} and {Soler Artigas}, Mar{\'i}a and Loth, {Daan W} and Wain, {Louise V} and Gharib, {Sina A} and Ma'en Obeidat and Wenbo Tang and Guangju Zhai and Zhao, {Jing Hua} and Smith, {Albert Vernon} and Huffman, {Jennifer E} and Eva Albrecht and Jackson, {Catherine M} and Evans, {David M} and Gemma Cadby and Myriam Fornage and Ani Manichaikul and Lopez, {Lorna M} and Toby Johnson and Aldrich, {Melinda C} and Thor Aspelund and In{\^e}s Barroso and Harry Campbell and Cassano, {Patricia A} and Couper, {David J} and Gudny Eiriksdottir and Nora Franceschini and Melissa Garcia and Christian Gieger and Gislason, {Gauti Kjartan} and Ivica Grkovic and Hammond, {Christopher J} and Hancock, {Dana B} and Harris, {Tamara B} and Adaikalavan Ramasamy and Heckbert, {Susan R} and Deary, {Ian J} and Harris, {Sarah E} and John Henderson and Hunter, {Michael L} and Kerr, {Shona M} and Andrew Morris and Porteous, {David J} and Starr, {John M} and Igor Rudan and Veronique Vitart and Wild, {Sarah H} and Wright, {Alan F} and Lina Zgaga and Wilson, {James F} and Caroline Hayward",

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month = nov,

doi = "10.1038/ng.941",

language = "English",

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International Lung Cancer Consortium, Soler Artigas, M, Loth, DW, Wain, LV, Gharib, SA, Obeidat, M, Tang, W, Zhai, G, Zhao, JH, Smith, AV, Huffman, JE, Albrecht, E, Jackson, CM, Evans, DM, Cadby, G, Fornage, M, Manichaikul, A, Lopez, LM, Johnson, T, Aldrich, MC, Aspelund, T, Barroso, I, Campbell, H, Cassano, PA, Couper, DJ, Eiriksdottir, G, Franceschini, N, Garcia, M, Gieger, C, Gislason, GK, Grkovic, I, Hammond, CJ, Hancock, DB, Harris, TB, Ramasamy, A, Heckbert, SR, Deary, IJ , Harris, SE, Henderson, J, Hunter, ML, Kerr, SM , Morris, A, Porteous, DJ, Starr, JM, Rudan, I , Vitart, V , Wild, SH, Wright, AF, Zgaga, L, Wilson, JF & Hayward, C 2011, 'Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function', Nature Genetics, vol. 43, no. 11, pp. 1082-90. https://doi.org/10.1038/ng.941

TY - JOUR

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AU - Soler Artigas, María

AU - Loth, Daan W

AU - Wain, Louise V

AU - Gharib, Sina A

AU - Obeidat, Ma'en

AU - Tang, Wenbo

AU - Zhai, Guangju

AU - Zhao, Jing Hua

AU - Smith, Albert Vernon

AU - Huffman, Jennifer E

AU - Albrecht, Eva

AU - Jackson, Catherine M

AU - Evans, David M

AU - Cadby, Gemma

AU - Fornage, Myriam

AU - Manichaikul, Ani

AU - Lopez, Lorna M

AU - Johnson, Toby

AU - Aldrich, Melinda C

AU - Aspelund, Thor

AU - Barroso, Inês

AU - Campbell, Harry

AU - Cassano, Patricia A

AU - Couper, David J

AU - Eiriksdottir, Gudny

AU - Franceschini, Nora

AU - Garcia, Melissa

AU - Gieger, Christian

AU - Gislason, Gauti Kjartan

AU - Grkovic, Ivica

AU - Hammond, Christopher J

AU - Hancock, Dana B

AU - Harris, Tamara B

AU - Ramasamy, Adaikalavan

AU - Heckbert, Susan R

AU - Deary, Ian J

AU - Harris, Sarah E

AU - Henderson, John

AU - Hunter, Michael L

AU - Kerr, Shona M

AU - Morris, Andrew

AU - Porteous, David J

AU - Starr, John M

AU - Rudan, Igor

AU - Vitart, Veronique

AU - Wild, Sarah H

AU - Wright, Alan F

AU - Zgaga, Lina

AU - Wilson, James F

AU - Hayward, Caroline

PY - 2011/11

Y1 - 2011/11

N2 - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

AB - Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 x 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

KW - OBSTRUCTIVE PULMONARY-DISEASE

KW - GENETIC-VARIATION

KW - BLOOD-PRESSURE

KW - VARIANTS

KW - METAANALYSIS

KW - RISK

KW - PROTEIN

KW - POLYMORPHISMS

KW - POPULATION

KW - EXPRESSION

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U2 - 10.1038/ng.941

DO - 10.1038/ng.941

M3 - Article

C2 - 21946350

SN - 1061-4036

VL - 43

SP - 1082

EP - 1090

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

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A genome wide association study of non pathological cognitive ageing

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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Abstract

Keywords / Materials (for Non-textual outputs)

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A genome wide association study of non pathological cognitive ageing

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