Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

NIDDK IBD Genetics Consortium, Belgian-French IBD Consortium, Wellcome Trust Case Control; Jeffrey C. Barrett; Sarah Hansoul; Dan L. Nicolae; Judy H. Cho; Richard H. Duerr; John D. Rioux; Steven R. Brant; Mark S. Silverberg; Kent D. Taylor; M. Michael Barmada; Alain Bitton; Themistocles Dassopoulos; Lisa Wu Datta; Todd Green; Anne M. Griffiths; Emily O. Kistner; Michael T. Murtha; Miguel D. Regueiro; Jerome I. Rotter; L. Philip Schumm; A. Hillary Steinhart; Stephan R. Targan; Ramnik J. Xavier; Cecile Libioulle; Cynthia Sandor; Mark Lathrop; Jacques Belaiche; Olivier Dewit; Ivo Gut; Simon Heath; Debby Laukens; Myriam Mni; Paul Rutgeerts; Andre Van Gossum; Diana Zelenika; Denis Franchimont; Jean-Pierre Hugot; Martine de Vos; Severine Vermeire; Edouard Louis; Lon R. Cardon; Carl A. Anderson; Hazel Drummond; Elaine Nimmo; Tariq Ahmad; Natalie J. Prescott; Clive M. Onnie; Sheila A. Fisher; Jonathan Marchini; Jack Satsangi

doi:10.1038/ng.175

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

NIDDK IBD Genetics Consortium, Belgian-French IBD Consortium, Wellcome Trust Case Control, Jeffrey C. Barrett, Sarah Hansoul, Dan L. Nicolae, Judy H. Cho, Richard H. Duerr, John D. Rioux, Steven R. Brant, Mark S. Silverberg, Kent D. Taylor, M. Michael Barmada, Alain Bitton, Themistocles Dassopoulos, Lisa Wu Datta, Todd Green, Anne M. Griffiths, Emily O. Kistner, Michael T. Murtha, Miguel D. Regueiro, Jerome I. RotterL. Philip Schumm, A. Hillary Steinhart, Stephan R. Targan, Ramnik J. Xavier, Cecile Libioulle, Cynthia Sandor, Mark Lathrop, Jacques Belaiche, Olivier Dewit, Ivo Gut, Simon Heath, Debby Laukens, Myriam Mni, Paul Rutgeerts, Andre Van Gossum, Diana Zelenika, Denis Franchimont, Jean-Pierre Hugot, Martine de Vos, Severine Vermeire, Edouard Louis, Lon R. Cardon, Carl A. Anderson, Hazel Drummond, Elaine Nimmo, Tariq Ahmad, Natalie J. Prescott, Clive M. Onnie, Sheila A. Fisher, Jonathan Marchini, Jack Satsangi

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

Original language	English
Pages (from-to)	955-962
Number of pages	8
Journal	Nature Genetics
Volume	40
Issue number	8
DOIs	https://doi.org/10.1038/ng.175
Publication status	Published - Aug 2008

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10.1038/ng.175

Genome-wide association defines more than thirty distinct susceptibility loci for Crohn's disease
Published in final edited form as: Nat Genet. 2008 August ; 40(8): 955–962. doi:10.1038/NG.175.
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http://www.nature.com/ng/journal/v40/n8/full/ng.175.html

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NIDDK IBD Genetics Consortium, Belgian-French IBD Consortium, Wellcome Trust Case Control, Barrett, J. C., Hansoul, S., Nicolae, D. L., Cho, J. H., Duerr, R. H., Rioux, J. D., Brant, S. R., Silverberg, M. S., Taylor, K. D., Barmada, M. M., Bitton, A., Dassopoulos, T., Datta, L. W., Green, T., Griffiths, A. M., Kistner, E. O., Murtha, M. T., Regueiro, M. D., ... Satsangi, J. (2008). Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature Genetics, 40(8), 955-962. https://doi.org/10.1038/ng.175

@article{b06387025cf84ebdab88fc2b5021fa2c,

title = "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease",

abstract = "Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.",

author = "{NIDDK IBD Genetics Consortium, Belgian-French IBD Consortium, Wellcome Trust Case Control} and Barrett, {Jeffrey C.} and Sarah Hansoul and Nicolae, {Dan L.} and Cho, {Judy H.} and Duerr, {Richard H.} and Rioux, {John D.} and Brant, {Steven R.} and Silverberg, {Mark S.} and Taylor, {Kent D.} and Barmada, {M. Michael} and Alain Bitton and Themistocles Dassopoulos and Datta, {Lisa Wu} and Todd Green and Griffiths, {Anne M.} and Kistner, {Emily O.} and Murtha, {Michael T.} and Regueiro, {Miguel D.} and Rotter, {Jerome I.} and Schumm, {L. Philip} and Steinhart, {A. Hillary} and Targan, {Stephan R.} and Xavier, {Ramnik J.} and Cecile Libioulle and Cynthia Sandor and Mark Lathrop and Jacques Belaiche and Olivier Dewit and Ivo Gut and Simon Heath and Debby Laukens and Myriam Mni and Paul Rutgeerts and {Van Gossum}, Andre and Diana Zelenika and Denis Franchimont and Jean-Pierre Hugot and {de Vos}, Martine and Severine Vermeire and Edouard Louis and Cardon, {Lon R.} and Anderson, {Carl A.} and Hazel Drummond and Elaine Nimmo and Tariq Ahmad and Prescott, {Natalie J.} and Onnie, {Clive M.} and Fisher, {Sheila A.} and Jonathan Marchini and Jack Satsangi",

year = "2008",

month = aug,

doi = "10.1038/ng.175",

language = "English",

volume = "40",

pages = "955--962",

journal = "Nature Genetics",

issn = "1061-4036",

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NIDDK IBD Genetics Consortium, Belgian-French IBD Consortium, Wellcome Trust Case Control, Barrett, JC, Hansoul, S, Nicolae, DL, Cho, JH, Duerr, RH, Rioux, JD, Brant, SR, Silverberg, MS, Taylor, KD, Barmada, MM, Bitton, A, Dassopoulos, T, Datta, LW, Green, T, Griffiths, AM, Kistner, EO, Murtha, MT, Regueiro, MD, Rotter, JI, Schumm, LP, Steinhart, AH, Targan, SR, Xavier, RJ, Libioulle, C, Sandor, C, Lathrop, M, Belaiche, J, Dewit, O, Gut, I, Heath, S, Laukens, D, Mni, M, Rutgeerts, P, Van Gossum, A, Zelenika, D, Franchimont, D, Hugot, J-P, de Vos, M, Vermeire, S, Louis, E, Cardon, LR, Anderson, CA, Drummond, H, Nimmo, E, Ahmad, T, Prescott, NJ, Onnie, CM, Fisher, SA, Marchini, J & Satsangi, J 2008, 'Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease', Nature Genetics, vol. 40, no. 8, pp. 955-962. https://doi.org/10.1038/ng.175

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AU - NIDDK IBD Genetics Consortium, Belgian-French IBD Consortium, Wellcome Trust Case Control

AU - Barrett, Jeffrey C.

AU - Hansoul, Sarah

AU - Nicolae, Dan L.

AU - Cho, Judy H.

AU - Duerr, Richard H.

AU - Rioux, John D.

AU - Brant, Steven R.

AU - Silverberg, Mark S.

AU - Taylor, Kent D.

AU - Barmada, M. Michael

AU - Bitton, Alain

AU - Dassopoulos, Themistocles

AU - Datta, Lisa Wu

AU - Green, Todd

AU - Griffiths, Anne M.

AU - Kistner, Emily O.

AU - Murtha, Michael T.

AU - Regueiro, Miguel D.

AU - Rotter, Jerome I.

AU - Schumm, L. Philip

AU - Steinhart, A. Hillary

AU - Targan, Stephan R.

AU - Xavier, Ramnik J.

AU - Libioulle, Cecile

AU - Sandor, Cynthia

AU - Lathrop, Mark

AU - Belaiche, Jacques

AU - Dewit, Olivier

AU - Gut, Ivo

AU - Heath, Simon

AU - Laukens, Debby

AU - Mni, Myriam

AU - Rutgeerts, Paul

AU - Van Gossum, Andre

AU - Zelenika, Diana

AU - Franchimont, Denis

AU - Hugot, Jean-Pierre

AU - de Vos, Martine

AU - Vermeire, Severine

AU - Louis, Edouard

AU - Cardon, Lon R.

AU - Anderson, Carl A.

AU - Drummond, Hazel

AU - Nimmo, Elaine

AU - Ahmad, Tariq

AU - Prescott, Natalie J.

AU - Onnie, Clive M.

AU - Fisher, Sheila A.

AU - Marchini, Jonathan

AU - Satsangi, Jack

PY - 2008/8

Y1 - 2008/8

N2 - Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

AB - Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

U2 - 10.1038/ng.175

DO - 10.1038/ng.175

M3 - Article

SN - 1061-4036

VL - 40

SP - 955

EP - 962

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

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