Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

Brent W Zanke; Celia M T Greenwood; Jagadish Rangrej; Rafal Kustra; Albert Tenesa; Susan M Farrington; James Prendergast; Sylviane Olschwang; Theodore Chiang; Edgar Crowdy; Vincent Ferretti; Philippe Laflamme; Saravanan Sundararajan; Stéphanie Roumy; Jean-François Olivier; Frédérick Robidoux; Robert Sladek; Alexandre Montpetit; Peter Campbell; Stephane Bezieau; Anne Marie O'Shea; George Zogopoulos; Michelle Cotterchio; Polly Newcomb; John McLaughlin; Ban Younghusband; Roger Green; Jane Green; Mary E M Porteous; Harry Campbell; Helene Blanche; Mourad Sahbatou; Emmanuel Tubacher; Catherine Bonaiti-Pellié; Bruno Buecher; Elio Riboli; Sebastien Kury; Stephen J Chanock; John Potter; Gilles Thomas; Steven Gallinger; Thomas J Hudson; Malcolm G Dunlop

doi:10.1038/ng2089

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

Brent W Zanke, Celia M T Greenwood, Jagadish Rangrej, Rafal Kustra, Albert Tenesa, Susan M Farrington, James Prendergast, Sylviane Olschwang, Theodore Chiang, Edgar Crowdy, Vincent Ferretti, Philippe Laflamme, Saravanan Sundararajan, Stéphanie Roumy, Jean-François Olivier, Frédérick Robidoux, Robert Sladek, Alexandre Montpetit, Peter Campbell, Stephane BezieauAnne Marie O'Shea, George Zogopoulos, Michelle Cotterchio, Polly Newcomb, John McLaughlin, Ban Younghusband, Roger Green, Jane Green, Mary E M Porteous, Harry Campbell, Helene Blanche, Mourad Sahbatou, Emmanuel Tubacher, Catherine Bonaiti-Pellié, Bruno Buecher, Elio Riboli, Sebastien Kury, Stephen J Chanock, John Potter, Gilles Thomas, Steven Gallinger, Thomas J Hudson, Malcolm G Dunlop

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.

Original language	English
Pages (from-to)	989-94
Number of pages	6
Journal	Nature Genetics
Volume	39
Issue number	8
DOIs	https://doi.org/10.1038/ng2089
Publication status	Published - 2007

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Zanke, B. W., Greenwood, C. M. T., Rangrej, J., Kustra, R., Tenesa, A., Farrington, S. M., Prendergast, J., Olschwang, S., Chiang, T., Crowdy, E., Ferretti, V., Laflamme, P., Sundararajan, S., Roumy, S., Olivier, J.-F., Robidoux, F., Sladek, R., Montpetit, A., Campbell, P., ... Dunlop, M. G. (2007). Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nature Genetics, 39(8), 989-94. https://doi.org/10.1038/ng2089

@article{57c05a86a2084fc48d8460102c2a3409,

title = "Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24",

abstract = "Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.",

author = "Zanke, {Brent W} and Greenwood, {Celia M T} and Jagadish Rangrej and Rafal Kustra and Albert Tenesa and Farrington, {Susan M} and James Prendergast and Sylviane Olschwang and Theodore Chiang and Edgar Crowdy and Vincent Ferretti and Philippe Laflamme and Saravanan Sundararajan and St{\'e}phanie Roumy and Jean-Fran{\c c}ois Olivier and Fr{\'e}d{\'e}rick Robidoux and Robert Sladek and Alexandre Montpetit and Peter Campbell and Stephane Bezieau and O'Shea, {Anne Marie} and George Zogopoulos and Michelle Cotterchio and Polly Newcomb and John McLaughlin and Ban Younghusband and Roger Green and Jane Green and Porteous, {Mary E M} and Harry Campbell and Helene Blanche and Mourad Sahbatou and Emmanuel Tubacher and Catherine Bonaiti-Pelli{\'e} and Bruno Buecher and Elio Riboli and Sebastien Kury and Chanock, {Stephen J} and John Potter and Gilles Thomas and Steven Gallinger and Hudson, {Thomas J} and Dunlop, {Malcolm G}",

year = "2007",

doi = "10.1038/ng2089",

language = "English",

volume = "39",

pages = "989--94",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "8",

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Zanke, BW, Greenwood, CMT, Rangrej, J, Kustra, R, Tenesa, A , Farrington, SM , Prendergast, J, Olschwang, S, Chiang, T, Crowdy, E, Ferretti, V, Laflamme, P, Sundararajan, S, Roumy, S, Olivier, J-F, Robidoux, F, Sladek, R, Montpetit, A, Campbell, P, Bezieau, S, O'Shea, AM, Zogopoulos, G, Cotterchio, M, Newcomb, P, McLaughlin, J, Younghusband, B, Green, R, Green, J, Porteous, MEM, Campbell, H, Blanche, H, Sahbatou, M, Tubacher, E, Bonaiti-Pellié, C, Buecher, B, Riboli, E, Kury, S, Chanock, SJ, Potter, J, Thomas, G, Gallinger, S, Hudson, TJ & Dunlop, MG 2007, 'Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24', Nature Genetics, vol. 39, no. 8, pp. 989-94. https://doi.org/10.1038/ng2089

TY - JOUR

T1 - Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

AU - Zanke, Brent W

AU - Greenwood, Celia M T

AU - Rangrej, Jagadish

AU - Kustra, Rafal

AU - Tenesa, Albert

AU - Farrington, Susan M

AU - Prendergast, James

AU - Olschwang, Sylviane

AU - Chiang, Theodore

AU - Crowdy, Edgar

AU - Ferretti, Vincent

AU - Laflamme, Philippe

AU - Sundararajan, Saravanan

AU - Roumy, Stéphanie

AU - Olivier, Jean-François

AU - Robidoux, Frédérick

AU - Sladek, Robert

AU - Montpetit, Alexandre

AU - Campbell, Peter

AU - Bezieau, Stephane

AU - O'Shea, Anne Marie

AU - Zogopoulos, George

AU - Cotterchio, Michelle

AU - Newcomb, Polly

AU - McLaughlin, John

AU - Younghusband, Ban

AU - Green, Roger

AU - Green, Jane

AU - Porteous, Mary E M

AU - Campbell, Harry

AU - Blanche, Helene

AU - Sahbatou, Mourad

AU - Tubacher, Emmanuel

AU - Bonaiti-Pellié, Catherine

AU - Buecher, Bruno

AU - Riboli, Elio

AU - Kury, Sebastien

AU - Chanock, Stephen J

AU - Potter, John

AU - Thomas, Gilles

AU - Gallinger, Steven

AU - Hudson, Thomas J

AU - Dunlop, Malcolm G

PY - 2007

Y1 - 2007

N2 - Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.

AB - Using a multistage genetic association approach comprising 7,480 affected individuals and 7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal cancer. In stage 1, we genotyped 99,632 SNPs in 1,257 affected individuals and 1,336 controls from Ontario. In stages 2-4, we performed serial replication studies using 4,024 affected individuals and 4,042 controls from Seattle, Newfoundland and Scotland. We identified one locus on chromosome 8q24 and another on 9p24 having combined odds ratios (OR) for stages 1-4 of 1.18 (trend; P = 1.41 x 10(-8)) and 1.14 (trend; P = 1.32 x 10(-5)), respectively. Additional analyses in 2,199 affected individuals and 2,401 controls from France and Europe supported the association at the 8q24 locus (OR = 1.16, trend; 95% confidence interval (c.i.): 1.07-1.26; P = 5.05 x 10(-4)). A summary across all seven studies at the 8q24 locus was highly significant (OR = 1.17, c.i.: 1.12-1.23; P = 3.16 x 10(-11)). This locus has also been implicated in prostate cancer.

U2 - 10.1038/ng2089

DO - 10.1038/ng2089

M3 - Article

C2 - 17618283

SN - 1061-4036

VL - 39

SP - 989

EP - 994

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

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