Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Daniel L. Mccartney; Josine L. Min; Rebecca C. Richmond; Ake T. Lu; Maria K. Sobczyk; Gail Davies; Linda Broer; Xiuqing Guo; Ayoung Jeong; Jeesun Jung; Silva Kasela; Seyma Katrinli; Pei-lun Kuo; Pamela R. Matias-garcia; Pashupati P. Mishra; Marianne Nygaard; Teemu Palviainen; Amit Patki; Laura M. Raffield; Scott M. Ratliff; Tom G. Richardson; Oliver Robinson; Mette Soerensen; Dianjianyi Sun; Pei-chien Tsai; Matthijs D. Van Der Zee; Rosie M. Walker; Xiaochuan Wang; Yunzhang Wang; Rui Xia; Zongli Xu; Jie Yao; Wei Zhao; Adolfo Correa; Eric Boerwinkle; Pierre-antoine Dugué; Peter Durda; Hannah R. Elliott; Christian Gieger; Eco J. C. De Geus; Sarah E. Harris; Gibran Hemani; Medea Imboden; Mika Kähönen; Sharon L. R. Kardia; Jacob K. Kresovich; Shengxu Li; Kathryn L. Lunetta; Massimo Mangino; Dan Mason; Andrew M. Mcintosh; Jonas Mengel-from; Ann Zenobia Moore; Joanne M. Murabito; Miina Ollikainen; James S. Pankow; Nancy L. Pedersen; Annette Peters; Silvia Polidoro; David J. Porteous; Olli Raitakari; Stephen S. Rich; Dale P. Sandler; Elina Sillanpää; Alicia K. Smith; Melissa C. Southey; Konstantin Strauch; Hemant Tiwari; Toshiko Tanaka; Therese Tillin; Andre G. Uitterlinden; David J. Van Den Berg; Jenny Van Dongen; James G. Wilson; John Wright; Idil Yet; Donna Arnett; Stefania Bandinelli; Jordana T. Bell; Alexandra M. Binder; Dorret I. Boomsma; Wei Chen; Kaare Christensen; Karen N. Conneely; Paul Elliott; Luigi Ferrucci; Myriam Fornage; Sara Hägg; Caroline Hayward; Marguerite Irvin; Jaakko Kaprio; Deborah A. Lawlor; Terho Lehtimäki; Falk W. Lohoff; Lili Milani; Roger L. Milne; Nicole Probst-hensch; Alex P. Reiner; Beate Ritz; Jerome I. Rotter; Jennifer A. Smith; Jack A. Taylor; Joyce B. J. Van Meurs; Paolo Vineis; Melanie Waldenberger; Ian J. Deary; Caroline L. Relton; Steve Horvath; Riccardo E. Marioni

doi:10.1186/s13059-021-02398-9

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Daniel L. Mccartney, Josine L. Min, Rebecca C. Richmond, Ake T. Lu, Maria K. Sobczyk, Gail Davies, Linda Broer, Xiuqing Guo, Ayoung Jeong, Jeesun Jung, Silva Kasela, Seyma Katrinli, Pei-lun Kuo, Pamela R. Matias-garcia, Pashupati P. Mishra, Marianne Nygaard, Teemu Palviainen, Amit Patki, Laura M. Raffield, Scott M. RatliffTom G. Richardson, Oliver Robinson, Mette Soerensen, Dianjianyi Sun, Pei-chien Tsai, Matthijs D. Van Der Zee, Rosie M. Walker, Xiaochuan Wang, Yunzhang Wang, Rui Xia, Zongli Xu, Jie Yao, Wei Zhao, Adolfo Correa, Eric Boerwinkle, Pierre-antoine Dugué, Peter Durda, Hannah R. Elliott, Christian Gieger, Eco J. C. De Geus, Sarah E. Harris, Gibran Hemani, Medea Imboden, Mika Kähönen, Sharon L. R. Kardia, Jacob K. Kresovich, Shengxu Li, Kathryn L. Lunetta, Massimo Mangino, Dan Mason, Andrew M. Mcintosh, Jonas Mengel-from, Ann Zenobia Moore, Joanne M. Murabito, Miina Ollikainen, James S. Pankow, Nancy L. Pedersen, Annette Peters, Silvia Polidoro, David J. Porteous, Olli Raitakari, Stephen S. Rich, Dale P. Sandler, Elina Sillanpää, Alicia K. Smith, Melissa C. Southey, Konstantin Strauch, Hemant Tiwari, Toshiko Tanaka, Therese Tillin, Andre G. Uitterlinden, David J. Van Den Berg, Jenny Van Dongen, James G. Wilson, John Wright, Idil Yet, Donna Arnett, Stefania Bandinelli, Jordana T. Bell, Alexandra M. Binder, Dorret I. Boomsma, Wei Chen, Kaare Christensen, Karen N. Conneely, Paul Elliott, Luigi Ferrucci, Myriam Fornage, Sara Hägg, Caroline Hayward, Marguerite Irvin, Jaakko Kaprio, Deborah A. Lawlor, Terho Lehtimäki, Falk W. Lohoff, Lili Milani, Roger L. Milne, Nicole Probst-hensch, Alex P. Reiner, Beate Ritz, Jerome I. Rotter, Jennifer A. Smith, Jack A. Taylor, Joyce B. J. Van Meurs, Paolo Vineis, Melanie Waldenberger, Ian J. Deary, Caroline L. Relton, Steve Horvath, Riccardo E. Marioni

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Genome Biology
Volume	22
Issue number	1
Early online date	29 Jun 2021
DOIs	https://doi.org/10.1186/s13059-021-02398-9
Publication status	Published - 29 Jun 2021

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10.1186/s13059-021-02398-9

s13059-021-02398-9Final published version, 1.67 MBLicence: Creative Commons: Attribution (CC-BY)

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-021-02398-9

Cite this

Mccartney, D. L., Min, J. L., Richmond, R. C., Lu, A. T., Sobczyk, M. K., Davies, G., Broer, L., Guo, X., Jeong, A., Jung, J., Kasela, S., Katrinli, S., Kuo, P., Matias-garcia, P. R., Mishra, P. P., Nygaard, M., Palviainen, T., Patki, A., Raffield, L. M., ... Marioni, R. E. (2021). Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biology, 22(1). https://doi.org/10.1186/s13059-021-02398-9

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title = "Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging",

author = "Mccartney, {Daniel L.} and Min, {Josine L.} and Richmond, {Rebecca C.} and Lu, {Ake T.} and Sobczyk, {Maria K.} and Gail Davies and Linda Broer and Xiuqing Guo and Ayoung Jeong and Jeesun Jung and Silva Kasela and Seyma Katrinli and Pei-lun Kuo and Matias-garcia, {Pamela R.} and Mishra, {Pashupati P.} and Marianne Nygaard and Teemu Palviainen and Amit Patki and Raffield, {Laura M.} and Ratliff, {Scott M.} and Richardson, {Tom G.} and Oliver Robinson and Mette Soerensen and Dianjianyi Sun and Pei-chien Tsai and {Van Der Zee}, {Matthijs D.} and Walker, {Rosie M.} and Xiaochuan Wang and Yunzhang Wang and Rui Xia and Zongli Xu and Jie Yao and Wei Zhao and Adolfo Correa and Eric Boerwinkle and Pierre-antoine Dugu{\'e} and Peter Durda and Elliott, {Hannah R.} and Christian Gieger and {De Geus}, {Eco J. C.} and Harris, {Sarah E.} and Gibran Hemani and Medea Imboden and Mika K{\"a}h{\"o}nen and Kardia, {Sharon L. R.} and Kresovich, {Jacob K.} and Shengxu Li and Lunetta, {Kathryn L.} and Massimo Mangino and Dan Mason and Mcintosh, {Andrew M.} and Jonas Mengel-from and Moore, {Ann Zenobia} and Murabito, {Joanne M.} and Miina Ollikainen and Pankow, {James S.} and Pedersen, {Nancy L.} and Annette Peters and Silvia Polidoro and Porteous, {David J.} and Olli Raitakari and Rich, {Stephen S.} and Sandler, {Dale P.} and Elina Sillanp{\"a}{\"a} and Smith, {Alicia K.} and Southey, {Melissa C.} and Konstantin Strauch and Hemant Tiwari and Toshiko Tanaka and Therese Tillin and Uitterlinden, {Andre G.} and {Van Den Berg}, {David J.} and {Van Dongen}, Jenny and Wilson, {James G.} and John Wright and Idil Yet and Donna Arnett and Stefania Bandinelli and Bell, {Jordana T.} and Binder, {Alexandra M.} and Boomsma, {Dorret I.} and Wei Chen and Kaare Christensen and Conneely, {Karen N.} and Paul Elliott and Luigi Ferrucci and Myriam Fornage and Sara H{\"a}gg and Caroline Hayward and Marguerite Irvin and Jaakko Kaprio and Lawlor, {Deborah A.} and Terho Lehtim{\"a}ki and Lohoff, {Falk W.} and Lili Milani and Milne, {Roger L.} and Nicole Probst-hensch and Reiner, {Alex P.} and Beate Ritz and Rotter, {Jerome I.} and Smith, {Jennifer A.} and Taylor, {Jack A.} and {Van Meurs}, {Joyce B. J.} and Paolo Vineis and Melanie Waldenberger and Deary, {Ian J.} and Relton, {Caroline L.} and Steve Horvath and Marioni, {Riccardo E.}",

year = "2021",

month = jun,

day = "29",

doi = "10.1186/s13059-021-02398-9",

language = "English",

volume = "22",

journal = "Genome Biology",

issn = "1465-6906",

publisher = "BioMed Central",

number = "1",

}

Mccartney, DL, Min, JL, Richmond, RC, Lu, AT, Sobczyk, MK, Davies, G, Broer, L, Guo, X, Jeong, A, Jung, J, Kasela, S, Katrinli, S, Kuo, P, Matias-garcia, PR, Mishra, PP, Nygaard, M, Palviainen, T, Patki, A, Raffield, LM, Ratliff, SM, Richardson, TG, Robinson, O, Soerensen, M, Sun, D, Tsai, P, Van Der Zee, MD, Walker, RM, Wang, X, Wang, Y, Xia, R, Xu, Z, Yao, J, Zhao, W, Correa, A, Boerwinkle, E, Dugué, P, Durda, P, Elliott, HR, Gieger, C, De Geus, EJC, Harris, SE, Hemani, G, Imboden, M, Kähönen, M, Kardia, SLR, Kresovich, JK, Li, S, Lunetta, KL, Mangino, M, Mason, D, Mcintosh, AM, Mengel-from, J, Moore, AZ, Murabito, JM, Ollikainen, M, Pankow, JS, Pedersen, NL, Peters, A, Polidoro, S, Porteous, DJ, Raitakari, O, Rich, SS, Sandler, DP, Sillanpää, E, Smith, AK, Southey, MC, Strauch, K, Tiwari, H, Tanaka, T, Tillin, T, Uitterlinden, AG, Van Den Berg, DJ, Van Dongen, J, Wilson, JG, Wright, J, Yet, I, Arnett, D, Bandinelli, S, Bell, JT, Binder, AM, Boomsma, DI, Chen, W, Christensen, K, Conneely, KN, Elliott, P, Ferrucci, L, Fornage, M, Hägg, S, Hayward, C, Irvin, M, Kaprio, J, Lawlor, DA, Lehtimäki, T, Lohoff, FW, Milani, L, Milne, RL, Probst-hensch, N, Reiner, AP, Ritz, B, Rotter, JI, Smith, JA, Taylor, JA, Van Meurs, JBJ, Vineis, P, Waldenberger, M, Deary, IJ, Relton, CL, Horvath, S & Marioni, RE 2021, 'Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging', Genome Biology, vol. 22, no. 1. https://doi.org/10.1186/s13059-021-02398-9

TY - JOUR

T1 - Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

AU - Mccartney, Daniel L.

AU - Min, Josine L.

AU - Richmond, Rebecca C.

AU - Lu, Ake T.

AU - Sobczyk, Maria K.

AU - Davies, Gail

AU - Broer, Linda

AU - Guo, Xiuqing

AU - Jeong, Ayoung

AU - Jung, Jeesun

AU - Kasela, Silva

AU - Katrinli, Seyma

AU - Kuo, Pei-lun

AU - Matias-garcia, Pamela R.

AU - Mishra, Pashupati P.

AU - Nygaard, Marianne

AU - Palviainen, Teemu

AU - Patki, Amit

AU - Raffield, Laura M.

AU - Ratliff, Scott M.

AU - Richardson, Tom G.

AU - Robinson, Oliver

AU - Soerensen, Mette

AU - Sun, Dianjianyi

AU - Tsai, Pei-chien

AU - Van Der Zee, Matthijs D.

AU - Walker, Rosie M.

AU - Wang, Xiaochuan

AU - Wang, Yunzhang

AU - Xia, Rui

AU - Xu, Zongli

AU - Yao, Jie

AU - Zhao, Wei

AU - Correa, Adolfo

AU - Boerwinkle, Eric

AU - Dugué, Pierre-antoine

AU - Durda, Peter

AU - Elliott, Hannah R.

AU - Gieger, Christian

AU - De Geus, Eco J. C.

AU - Harris, Sarah E.

AU - Hemani, Gibran

AU - Imboden, Medea

AU - Kähönen, Mika

AU - Kardia, Sharon L. R.

AU - Kresovich, Jacob K.

AU - Li, Shengxu

AU - Lunetta, Kathryn L.

AU - Mangino, Massimo

AU - Mason, Dan

AU - Mcintosh, Andrew M.

AU - Mengel-from, Jonas

AU - Moore, Ann Zenobia

AU - Murabito, Joanne M.

AU - Ollikainen, Miina

AU - Pankow, James S.

AU - Pedersen, Nancy L.

AU - Peters, Annette

AU - Polidoro, Silvia

AU - Porteous, David J.

AU - Raitakari, Olli

AU - Rich, Stephen S.

AU - Sandler, Dale P.

AU - Sillanpää, Elina

AU - Smith, Alicia K.

AU - Southey, Melissa C.

AU - Strauch, Konstantin

AU - Tiwari, Hemant

AU - Tanaka, Toshiko

AU - Tillin, Therese

AU - Uitterlinden, Andre G.

AU - Van Den Berg, David J.

AU - Van Dongen, Jenny

AU - Wilson, James G.

AU - Wright, John

AU - Yet, Idil

AU - Arnett, Donna

AU - Bandinelli, Stefania

AU - Bell, Jordana T.

AU - Binder, Alexandra M.

AU - Boomsma, Dorret I.

AU - Chen, Wei

AU - Christensen, Kaare

AU - Conneely, Karen N.

AU - Elliott, Paul

AU - Ferrucci, Luigi

AU - Fornage, Myriam

AU - Hägg, Sara

AU - Hayward, Caroline

AU - Irvin, Marguerite

AU - Kaprio, Jaakko

AU - Lawlor, Deborah A.

AU - Lehtimäki, Terho

AU - Lohoff, Falk W.

AU - Milani, Lili

AU - Milne, Roger L.

AU - Probst-hensch, Nicole

AU - Reiner, Alex P.

AU - Ritz, Beate

AU - Rotter, Jerome I.

AU - Smith, Jennifer A.

AU - Taylor, Jack A.

AU - Van Meurs, Joyce B. J.

AU - Vineis, Paolo

AU - Waldenberger, Melanie

AU - Deary, Ian J.

AU - Relton, Caroline L.

AU - Horvath, Steve

AU - Marioni, Riccardo E.

PY - 2021/6/29

Y1 - 2021/6/29

U2 - 10.1186/s13059-021-02398-9

DO - 10.1186/s13059-021-02398-9

M3 - Article

SN - 1465-6906

VL - 22

JO - Genome Biology

JF - Genome Biology

IS - 1

ER -