Abstract
Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fracture applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55 years; and comprising 329 cases and 2666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursued by de-novo genotyping of 15 independent studies across Europe, the United States, and Australia and one Asian study. Radiographic vertebral fracture assessment was performed using McCloskey-Kanis or Genant semi-quantitative definitions. SNPs were analyzed in relation to vertebral fracture using logistic regression models corrected for age and sex. Fixed effects inverse variance and Han-Eskin alternative random effects meta-analyses were applied. Genome-wide significance was set at p1.25) may still be consistent with an effect size
Original language | English |
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Pages (from-to) | 20-27 |
Number of pages | 8 |
Journal | Bone |
Volume | 59 |
DOIs | |
Publication status | Published - Feb 2014 |
Keywords / Materials (for Non-textual outputs)
- Genome-wide association study
- Vertebral fracture risk
- Genetics of osteoporosis
- GEFOS consortium
- FOXC2
- BONE-MINERAL DENSITY
- QUALITY-OF-LIFE
- EUROPEAN PROSPECTIVE OSTEOPOROSIS
- POSTMENOPAUSAL WOMEN
- GEELONG-OSTEOPOROSIS
- TURNOVER MARKERS
- CAMARGO COHORT
- ELDERLY-WOMEN
- DOUBLE-BLIND
- MEN