Abstract
Rhegmatogenous retinal detachment (RRD) is an important cause of vision loss and can potentially lead to blindness. The underlying pathogenesis is complex and incompletely understood. We applied a two-stage genetic association discovery phase followed by a replication phase in a combined total of 2,833 RRD cases and 7,871 controls. The discovery phase involved a genome-wide association scan of 867 affected individuals and 1953 controls from Scotland, followed by genotyping and testing 4,347 highest ranking or candidates SNPs in independent sets of cases (1,000) and controls (2,912) of Dutch and British origin. None of the SNPs selected reached a Bonferroni-corrected threshold for significance (p
Original language | English |
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Pages (from-to) | 3174-3185 |
Journal | Human Molecular Genetics |
Volume | 22 |
Issue number | 15 |
Early online date | 11 Apr 2013 |
DOIs | |
Publication status | Published - 1 Aug 2013 |