TY - JOUR
T1 - Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
AU - DIAGRAM Consortium
AU - Demirkan, Ayşe
AU - van Duijn, Cornelia M
AU - Ugocsai, Peter
AU - Isaacs, Aaron
AU - Pramstaller, Peter P
AU - Liebisch, Gerhard
AU - Wilson, James F
AU - Johansson, Åsa
AU - Rudan, Igor
AU - Aulchenko, Yurii S
AU - Kirichenko, Anatoly V
AU - Janssens, A Cecile J W
AU - Jansen, Ritsert C
AU - Gnewuch, Carsten
AU - Domingues, Francisco S
AU - Pattaro, Cristian
AU - Wild, Sarah H
AU - Jonasson, Inger
AU - Polasek, Ozren
AU - Zorkoltseva, Irina V
AU - Hofman, Albert
AU - Karssen, Lennart C
AU - Struchalin, Maksim
AU - Floyd, James
AU - Igl, Wilmar
AU - Biloglav, Zrinka
AU - Broer, Linda
AU - Pfeufer, Arne
AU - Pichler, Irene
AU - Campbell, Susan
AU - Zaboli, Ghazal
AU - Kolcic, Ivana
AU - Rivadeneira, Fernando
AU - Huffman, Jennifer
AU - Hastie, Nicholas D
AU - Uitterlinden, Andre
AU - Franke, Lude
AU - Franklin, Christopher S
AU - Vitart, Veronique
AU - Nelson, Christopher P
AU - Preuss, Michael
AU - Bis, Joshua C
AU - O'Donnell, Christopher J
AU - Franceschini, Nora
AU - Witteman, Jacqueline C M
AU - Axenovich, Tatiana
AU - Oostra, Ben A
AU - Hayward, Caroline
AU - Wright, Alan F
AU - Campbell, Harry
PY - 2012
Y1 - 2012
N2 - Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88×10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10×10(-57)). After a correction for multiple comparisons (P-value
AB - Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88×10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10×10(-57)). After a correction for multiple comparisons (P-value
UR - http://www.scopus.com/inward/record.url?scp=84859190557&partnerID=8YFLogxK
U2 - 10.1371/journal.pgen.1002490
DO - 10.1371/journal.pgen.1002490
M3 - Article
C2 - 22359512
SN - 1553-7404
VL - 8
SP - e1002490
JO - PLoS Genetics
JF - PLoS Genetics
IS - 2
ER -