Genome-wide association uncovers shared genetic effects among personality traits and mood states

Michelle Luciano; Jennifer E Huffman; Alejandro Arias-Vásquez; Anna A E Vinkhuyzen; Christel M Middeldorp; Ina Giegling; Antony Payton; Gail Davies; Lina Zgaga; Joost Janzing; Xiayi Ke; Tessel Galesloot; Annette M Hartmann; William Ollier; Albert Tenesa; Caroline Hayward; Maaike Verhagen; Grant W Montgomery; Jouke-Jan Hottenga; Bettina Konte; John M Starr; Veronique Vitart; Pieter E Vos; Pamela A F Madden; Gonneke Willemsen; Heike Konnerth; Michael A Horan; David J Porteous; Harry Campbell; Sita H Vermeulen; Andrew C Heath; Alan Wright; Ozren Polasek; Sanja B Kovacevic; Nicholas D Hastie; Barbara Franke; Dorret I Boomsma; Nicholas G Martin; Dan Rujescu; James F Wilson; Jan Buitelaar; Neil Pendleton; Igor Rudan; Ian J Deary

doi:10.1002/ajmg.b.32072

Genome-wide association uncovers shared genetic effects among personality traits and mood states

Michelle Luciano, Jennifer E Huffman, Alejandro Arias-Vásquez, Anna A E Vinkhuyzen, Christel M Middeldorp, Ina Giegling, Antony Payton, Gail Davies, Lina Zgaga, Joost Janzing, Xiayi Ke, Tessel Galesloot, Annette M Hartmann, William Ollier, Albert Tenesa, Caroline Hayward, Maaike Verhagen, Grant W Montgomery, Jouke-Jan Hottenga, Bettina KonteJohn M Starr, Veronique Vitart, Pieter E Vos, Pamela A F Madden, Gonneke Willemsen, Heike Konnerth, Michael A Horan, David J Porteous, Harry Campbell, Sita H Vermeulen, Andrew C Heath, Alan Wright, Ozren Polasek, Sanja B Kovacevic, Nicholas D Hastie, Barbara Franke, Dorret I Boomsma, Nicholas G Martin, Dan Rujescu, James F Wilson, Jan Buitelaar, Neil Pendleton, Igor Rudan, Ian J Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n = 6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n = 527-6,032). Suggestive association (P = 8 × 10(-8) ) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P

Original language	English
Pages (from-to)	684-695
Journal	American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume	159B
Issue number	6
Early online date	26 May 2012
DOIs	https://doi.org/10.1002/ajmg.b.32072
Publication status	Published - 1 Sept 2012

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10.1002/ajmg.b.32072

Genome-wide association uncovers shared genetic effects among personality traits and mood states
The publisher's final edited version of this article is available at Am J Med Genet B Neuropsychiatr Genet
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http://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32072/abstract

A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921
Deary, I. (Principal Investigator), Bates, T. (Co-investigator), Gow, A. (Co-investigator) & Starr, J. (Co-investigator)
UK central government bodies/local authorities, health and hospital authorities
1/01/11 → 31/12/12
Project: Research
Disconnected Mind [Phase 2]
Wardlaw, J. (Principal Investigator)
UK-based charities
1/01/11 → 31/03/16
Project: Research
MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I. (Principal Investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), McCulloch, J. (Co-investigator), Porteous, D. (Co-investigator), Roberts, N. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
1/09/08 → 31/08/13
Project: Research

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Luciano, M., Huffman, J. E., Arias-Vásquez, A., Vinkhuyzen, A. A. E., Middeldorp, C. M., Giegling, I., Payton, A., Davies, G., Zgaga, L., Janzing, J., Ke, X., Galesloot, T., Hartmann, A. M., Ollier, W., Tenesa, A., Hayward, C., Verhagen, M., Montgomery, G. W., Hottenga, J.-J., ... Deary, I. J. (2012). Genome-wide association uncovers shared genetic effects among personality traits and mood states. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 159B(6), 684-695. https://doi.org/10.1002/ajmg.b.32072

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abstract = "Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n = 6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n = 527-6,032). Suggestive association (P = 8 × 10(-8) ) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P ",

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Luciano, M, Huffman, JE, Arias-Vásquez, A, Vinkhuyzen, AAE, Middeldorp, CM, Giegling, I, Payton, A, Davies, G, Zgaga, L, Janzing, J, Ke, X, Galesloot, T, Hartmann, AM, Ollier, W, Tenesa, A , Hayward, C, Verhagen, M, Montgomery, GW, Hottenga, J-J, Konte, B, Starr, JM, Vitart, V, Vos, PE, Madden, PAF, Willemsen, G, Konnerth, H, Horan, MA, Porteous, DJ, Campbell, H, Vermeulen, SH, Heath, AC, Wright, A, Polasek, O, Kovacevic, SB, Hastie, ND, Franke, B, Boomsma, DI, Martin, NG, Rujescu, D, Wilson, JF, Buitelaar, J, Pendleton, N, Rudan, I & Deary, IJ 2012, 'Genome-wide association uncovers shared genetic effects among personality traits and mood states', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 159B, no. 6, pp. 684-695. https://doi.org/10.1002/ajmg.b.32072

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AU - Luciano, Michelle

AU - Huffman, Jennifer E

AU - Arias-Vásquez, Alejandro

AU - Vinkhuyzen, Anna A E

AU - Middeldorp, Christel M

AU - Giegling, Ina

AU - Payton, Antony

AU - Davies, Gail

AU - Zgaga, Lina

AU - Janzing, Joost

AU - Ke, Xiayi

AU - Galesloot, Tessel

AU - Hartmann, Annette M

AU - Ollier, William

AU - Tenesa, Albert

AU - Hayward, Caroline

AU - Verhagen, Maaike

AU - Montgomery, Grant W

AU - Hottenga, Jouke-Jan

AU - Konte, Bettina

AU - Starr, John M

AU - Vitart, Veronique

AU - Vos, Pieter E

AU - Madden, Pamela A F

AU - Willemsen, Gonneke

AU - Konnerth, Heike

AU - Horan, Michael A

AU - Porteous, David J

AU - Campbell, Harry

AU - Vermeulen, Sita H

AU - Heath, Andrew C

AU - Wright, Alan

AU - Polasek, Ozren

AU - Kovacevic, Sanja B

AU - Hastie, Nicholas D

AU - Franke, Barbara

AU - Boomsma, Dorret I

AU - Martin, Nicholas G

AU - Rujescu, Dan

AU - Wilson, James F

AU - Buitelaar, Jan

AU - Pendleton, Neil

AU - Rudan, Igor

AU - Deary, Ian J

PY - 2012/9/1

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AB - Measures of personality and psychological distress are correlated and exhibit genetic covariance. We conducted univariate genome-wide SNP (∼2.5 million) and gene-based association analyses of these traits and examined the overlap in results across traits, including a prediction analysis of mood states using genetic polygenic scores for personality. Measures of neuroticism, extraversion, and symptoms of anxiety, depression, and general psychological distress were collected in eight European cohorts (n ranged 546-1,338; maximum total n = 6,268) whose mean age ranged from 55 to 79 years. Meta-analysis of the cohort results was performed, with follow-up associations of the top SNPs and genes investigated in independent cohorts (n = 527-6,032). Suggestive association (P = 8 × 10(-8) ) of rs1079196 in the FHIT gene was observed with symptoms of anxiety. Other notable associations (P

U2 - 10.1002/ajmg.b.32072

DO - 10.1002/ajmg.b.32072

M3 - Article

C2 - 22628180

SN - 1552-485X

VL - 159B

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EP - 695

JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

IS - 6

ER -

Genome-wide association uncovers shared genetic effects among personality traits and mood states

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Projects

A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921

Disconnected Mind [Phase 2]

MRC Centre for Cognitive Ageing and Cognitive Epidemiology

Cite this