Genome-wide meta-analysis identifies novel gender specific loci associated with thyroid antibodies level in Croatians

Antonela Matana, Marijana Popović, Thibaud Boutin, Vesela Torlak, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Caroline Hayward, Maja Barbalić, Tatijana Zemunik

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune thyroid diseases (AITD) are multifactorial endocrine diseases most frequently accompanied by Tg and TPO autoantibodies. Both antibodies have a higher prevalence in females and act under a strong genetic influence. To identify novel variants underlying thyroid antibody levels, we performed GWAS meta-analysis on the plasma levels of TgAb and TPOAb in three Croatian cohorts, as well as gender specific GWAS and a bivariate analysis. No significant association was detected with the level of TgAb and TPOAb in the meta-analysis of GWAS or bivariate results for all individuals. The bivariate analysis in females only revealed a genome-wide significant association for the locus near GRIN3A (rs4457391, P = 7.76 × 10-9). The same locus had borderline association with TPOAb levels in females (rs1935377, P = 8.58 × 10-8). In conclusion, we identified a novel gender specific locus associated with TgAb and TPOAb levels. Our findings provide a novel insight into genetic and gender differences associated with thyroid antibodies.

Original languageEnglish
JournalGenomics
Early online date18 Apr 2018
DOIs
Publication statusE-pub ahead of print - 18 Apr 2018

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