Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Josine L. Min; Gibran Hemani; Eilis Hannon; Koen F. Dekkers; Juan Castillo-fernandez; René Luijk; Elena Carnero-montoro; Daniel J. Lawson; Kimberley Burrows; Matthew Suderman; Andrew D. Bretherick; Tom G. Richardson; Johanna Klughammer; Valentina Iotchkova; Gemma Sharp; Ahmad Al Khleifat; Aleksey Shatunov; Alfredo Iacoangeli; Wendy L. Mcardle; Karen M. Ho; Ashish Kumar; Cilla Söderhäll; Carolina Soriano-tárraga; Eva Giralt-steinhauer; Nabila Kazmi; Dan Mason; Allan F. Mcrae; David L. Corcoran; Karen Sugden; Silva Kasela; Alexia Cardona; Felix R. Day; Giovanni Cugliari; Clara Viberti; Simonetta Guarrera; Michael Lerro; Richa Gupta; Sailalitha Bollepalli; Pooja Mandaviya; Yanni Zeng; Toni-kim Clarke; Rosie M. Walker; Vanessa Schmoll; Darina Czamara; Carlos Ruiz-arenas; Faisal I. Rezwan; Riccardo E. Marioni; Tian Lin; Yvonne Awaloff; Marine Germain; Dylan Aïssi; Ramona Zwamborn; Kristel Van Eijk; Annelot Dekker; Jenny Van Dongen; Jouke-jan Hottenga; Gonneke Willemsen; Cheng-jian Xu; Guillermo Barturen; Francesc Català-moll; Martin Kerick; Carol Wang; Phillip Melton; Hannah R. Elliott; Jean Shin; Manon Bernard; Idil Yet; Melissa Smart; Tyler Gorrie-stone; Chris Shaw; Ammar Al Chalabi; Susan M. Ring; Göran Pershagen; Erik Melén; Jordi Jiménez-conde; Jaume Roquer; Deborah A. Lawlor; John Wright; Nicholas G. Martin; Grant W. Montgomery; Terrie E. Moffitt; Richie Poulton; Tõnu Esko; Lili Milani; Andres Metspalu; John R. B. Perry; Ken K. Ong; Nicholas J. Wareham; Giuseppe Matullo; Carlotta Sacerdote; Salvatore Panico; Avshalom Caspi; Louise Arseneault; France Gagnon; Miina Ollikainen; Jaakko Kaprio; Janine F. Felix; Fernando Rivadeneira; Henning Tiemeier; Marinus H. Van Ijzendoorn; André G. Uitterlinden; Vincent W. V. Jaddoe; Chris Haley; Andrew M. Mcintosh; Kathryn L. Evans; Katri Räikkönen; Jari Lahti; Ellen A. Nohr; Thorkild I. A. Sørensen; Torben Hansen; Camilla S. Morgen; Elisabeth B. Binder; Susanne Lucae; Juan Ramon Gonzalez; Mariona Bustamante; Jordi Sunyer; John W. Holloway; Wilfried Karmaus; Hongmei Zhang; Ian J. Deary; Naomi R. Wray; John M. Starr; Marian Beekman; Diana Van Heemst; P. Eline Slagboom; Pierre-emmanuel Morange; David-alexandre Trégouët; Jan H. Veldink; Gareth E. Davies; Eco J. C. De Geus; Dorret I. Boomsma; Judith M. Vonk; Bert Brunekreef; Gerard H. Koppelman; Marta E. Alarcón-riquelme; Rae-chi Huang; Craig E. Pennell; Joyce Van Meurs; M. Arfan Ikram; Alun D. Hughes; Therese Tillin; Nish Chaturvedi; Zdenka Pausova; Tomas Paus; Timothy D. Spector; Meena Kumari; Leonard C. Schalkwyk; Peter M. Visscher; George Davey Smith; Christoph Bock; Tom R. Gaunt; Jordana T. Bell; Bastiaan T. Heijmans; Jonathan Mill; Caroline L. Relton

doi:10.1038/s41588-021-00923-x

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

Josine L. Min, Gibran Hemani, Eilis Hannon, Koen F. Dekkers, Juan Castillo-fernandez, René Luijk, Elena Carnero-montoro, Daniel J. Lawson, Kimberley Burrows, Matthew Suderman, Andrew D. Bretherick, Tom G. Richardson, Johanna Klughammer, Valentina Iotchkova, Gemma Sharp, Ahmad Al Khleifat, Aleksey Shatunov, Alfredo Iacoangeli, Wendy L. Mcardle, Karen M. HoAshish Kumar, Cilla Söderhäll, Carolina Soriano-tárraga, Eva Giralt-steinhauer, Nabila Kazmi, Dan Mason, Allan F. Mcrae, David L. Corcoran, Karen Sugden, Silva Kasela, Alexia Cardona, Felix R. Day, Giovanni Cugliari, Clara Viberti, Simonetta Guarrera, Michael Lerro, Richa Gupta, Sailalitha Bollepalli, Pooja Mandaviya, Yanni Zeng, Toni-kim Clarke, Rosie M. Walker, Vanessa Schmoll, Darina Czamara, Carlos Ruiz-arenas, Faisal I. Rezwan, Riccardo E. Marioni, Tian Lin, Yvonne Awaloff, Marine Germain, Dylan Aïssi, Ramona Zwamborn, Kristel Van Eijk, Annelot Dekker, Jenny Van Dongen, Jouke-jan Hottenga, Gonneke Willemsen, Cheng-jian Xu, Guillermo Barturen, Francesc Català-moll, Martin Kerick, Carol Wang, Phillip Melton, Hannah R. Elliott, Jean Shin, Manon Bernard, Idil Yet, Melissa Smart, Tyler Gorrie-stone, Chris Shaw, Ammar Al Chalabi, Susan M. Ring, Göran Pershagen, Erik Melén, Jordi Jiménez-conde, Jaume Roquer, Deborah A. Lawlor, John Wright, Nicholas G. Martin, Grant W. Montgomery, Terrie E. Moffitt, Richie Poulton, Tõnu Esko, Lili Milani, Andres Metspalu, John R. B. Perry, Ken K. Ong, Nicholas J. Wareham, Giuseppe Matullo, Carlotta Sacerdote, Salvatore Panico, Avshalom Caspi, Louise Arseneault, France Gagnon, Miina Ollikainen, Jaakko Kaprio, Janine F. Felix, Fernando Rivadeneira, Henning Tiemeier, Marinus H. Van Ijzendoorn, André G. Uitterlinden, Vincent W. V. Jaddoe, Chris Haley, Andrew M. Mcintosh, Kathryn L. Evans, Katri Räikkönen, Jari Lahti, Ellen A. Nohr, Thorkild I. A. Sørensen, Torben Hansen, Camilla S. Morgen, Elisabeth B. Binder, Susanne Lucae, Juan Ramon Gonzalez, Mariona Bustamante, Jordi Sunyer, John W. Holloway, Wilfried Karmaus, Hongmei Zhang, Ian J. Deary, Naomi R. Wray, John M. Starr, Marian Beekman, Diana Van Heemst, P. Eline Slagboom, Pierre-emmanuel Morange, David-alexandre Trégouët, Jan H. Veldink, Gareth E. Davies, Eco J. C. De Geus, Dorret I. Boomsma, Judith M. Vonk, Bert Brunekreef, Gerard H. Koppelman, Marta E. Alarcón-riquelme, Rae-chi Huang, Craig E. Pennell, Joyce Van Meurs, M. Arfan Ikram, Alun D. Hughes, Therese Tillin, Nish Chaturvedi, Zdenka Pausova, Tomas Paus, Timothy D. Spector, Meena Kumari, Leonard C. Schalkwyk, Peter M. Visscher, George Davey Smith, Christoph Bock, Tom R. Gaunt, Jordana T. Bell, Bastiaan T. Heijmans, Jonathan Mill, Caroline L. Relton

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1311-1321
Journal	Nature Genetics
Volume	53
Issue number	9
DOIs	https://doi.org/10.1038/s41588-021-00923-x
Publication status	Published - 6 Sept 2021

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10.1038/s41588-021-00923-x

https://www.nature.com/articles/s41588-021-00923-x

Cite this

Min, J. L., Hemani, G., Hannon, E., Dekkers, K. F., Castillo-fernandez, J., Luijk, R., Carnero-montoro, E., Lawson, D. J., Burrows, K., Suderman, M., Bretherick, A. D., Richardson, T. G., Klughammer, J., Iotchkova, V., Sharp, G., Al Khleifat, A., Shatunov, A., Iacoangeli, A., Mcardle, W. L., ... Relton, C. L. (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics, 53(9), 1311-1321. https://doi.org/10.1038/s41588-021-00923-x

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author = "Min, {Josine L.} and Gibran Hemani and Eilis Hannon and Dekkers, {Koen F.} and Juan Castillo-fernandez and Ren{\'e} Luijk and Elena Carnero-montoro and Lawson, {Daniel J.} and Kimberley Burrows and Matthew Suderman and Bretherick, {Andrew D.} and Richardson, {Tom G.} and Johanna Klughammer and Valentina Iotchkova and Gemma Sharp and {Al Khleifat}, Ahmad and Aleksey Shatunov and Alfredo Iacoangeli and Mcardle, {Wendy L.} and Ho, {Karen M.} and Ashish Kumar and Cilla S{\"o}derh{\"a}ll and Carolina Soriano-t{\'a}rraga and Eva Giralt-steinhauer and Nabila Kazmi and Dan Mason and Mcrae, {Allan F.} and Corcoran, {David L.} and Karen Sugden and Silva Kasela and Alexia Cardona and Day, {Felix R.} and Giovanni Cugliari and Clara Viberti and Simonetta Guarrera and Michael Lerro and Richa Gupta and Sailalitha Bollepalli and Pooja Mandaviya and Yanni Zeng and Toni-kim Clarke and Walker, {Rosie M.} and Vanessa Schmoll and Darina Czamara and Carlos Ruiz-arenas and Rezwan, {Faisal I.} and Marioni, {Riccardo E.} and Tian Lin and Yvonne Awaloff and Marine Germain and Dylan A{\"i}ssi and Ramona Zwamborn and {Van Eijk}, Kristel and Annelot Dekker and {Van Dongen}, Jenny and Jouke-jan Hottenga and Gonneke Willemsen and Cheng-jian Xu and Guillermo Barturen and Francesc Catal{\`a}-moll and Martin Kerick and Carol Wang and Phillip Melton and Elliott, {Hannah R.} and Jean Shin and Manon Bernard and Idil Yet and Melissa Smart and Tyler Gorrie-stone and Chris Shaw and {Al Chalabi}, Ammar and Ring, {Susan M.} and G{\"o}ran Pershagen and Erik Mel{\'e}n and Jordi Jim{\'e}nez-conde and Jaume Roquer and Lawlor, {Deborah A.} and John Wright and Martin, {Nicholas G.} and Montgomery, {Grant W.} and Moffitt, {Terrie E.} and Richie Poulton and T{\~o}nu Esko and Lili Milani and Andres Metspalu and Perry, {John R. B.} and Ong, {Ken K.} and Wareham, {Nicholas J.} and Giuseppe Matullo and Carlotta Sacerdote and Salvatore Panico and Avshalom Caspi and Louise Arseneault and France Gagnon and Miina Ollikainen and Jaakko Kaprio and Felix, {Janine F.} and Fernando Rivadeneira and Henning Tiemeier and {Van Ijzendoorn}, {Marinus H.} and Uitterlinden, {Andr{\'e} G.} and Jaddoe, {Vincent W. V.} and Chris Haley and Mcintosh, {Andrew M.} and Evans, {Kathryn L.} and Katri R{\"a}ikk{\"o}nen and Jari Lahti and Nohr, {Ellen A.} and S{\o}rensen, {Thorkild I. A.} and Torben Hansen and Morgen, {Camilla S.} and Binder, {Elisabeth B.} and Susanne Lucae and Gonzalez, {Juan Ramon} and Mariona Bustamante and Jordi Sunyer and Holloway, {John W.} and Wilfried Karmaus and Hongmei Zhang and Deary, {Ian J.} and Wray, {Naomi R.} and Starr, {John M.} and Marian Beekman and {Van Heemst}, Diana and Slagboom, {P. Eline} and Pierre-emmanuel Morange and David-alexandre Tr{\'e}gou{\"e}t and Veldink, {Jan H.} and Davies, {Gareth E.} and {De Geus}, {Eco J. C.} and Boomsma, {Dorret I.} and Vonk, {Judith M.} and Bert Brunekreef and Koppelman, {Gerard H.} and Alarc{\'o}n-riquelme, {Marta E.} and Rae-chi Huang and Pennell, {Craig E.} and {Van Meurs}, Joyce and Ikram, {M. Arfan} and Hughes, {Alun D.} and Therese Tillin and Nish Chaturvedi and Zdenka Pausova and Tomas Paus and Spector, {Timothy D.} and Meena Kumari and Schalkwyk, {Leonard C.} and Visscher, {Peter M.} and {Davey Smith}, George and Christoph Bock and Gaunt, {Tom R.} and Bell, {Jordana T.} and Heijmans, {Bastiaan T.} and Jonathan Mill and Relton, {Caroline L.}",

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month = sep,

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doi = "10.1038/s41588-021-00923-x",

language = "English",

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Min, JL, Hemani, G, Hannon, E, Dekkers, KF, Castillo-fernandez, J, Luijk, R, Carnero-montoro, E, Lawson, DJ, Burrows, K, Suderman, M, Bretherick, AD, Richardson, TG, Klughammer, J, Iotchkova, V, Sharp, G, Al Khleifat, A, Shatunov, A, Iacoangeli, A, Mcardle, WL, Ho, KM, Kumar, A, Söderhäll, C, Soriano-tárraga, C, Giralt-steinhauer, E, Kazmi, N, Mason, D, Mcrae, AF, Corcoran, DL, Sugden, K, Kasela, S, Cardona, A, Day, FR, Cugliari, G, Viberti, C, Guarrera, S, Lerro, M, Gupta, R, Bollepalli, S, Mandaviya, P, Zeng, Y, Clarke, T, Walker, RM, Schmoll, V, Czamara, D, Ruiz-arenas, C, Rezwan, FI, Marioni, RE, Lin, T, Awaloff, Y, Germain, M, Aïssi, D, Zwamborn, R, Van Eijk, K, Dekker, A, Van Dongen, J, Hottenga, J, Willemsen, G, Xu, C, Barturen, G, Català-moll, F, Kerick, M, Wang, C, Melton, P, Elliott, HR, Shin, J, Bernard, M, Yet, I, Smart, M, Gorrie-stone, T, Shaw, C, Al Chalabi, A, Ring, SM, Pershagen, G, Melén, E, Jiménez-conde, J, Roquer, J, Lawlor, DA, Wright, J, Martin, NG, Montgomery, GW, Moffitt, TE, Poulton, R, Esko, T, Milani, L, Metspalu, A, Perry, JRB, Ong, KK, Wareham, NJ, Matullo, G, Sacerdote, C, Panico, S, Caspi, A, Arseneault, L, Gagnon, F, Ollikainen, M, Kaprio, J, Felix, JF, Rivadeneira, F, Tiemeier, H, Van Ijzendoorn, MH, Uitterlinden, AG, Jaddoe, VWV, Haley, C, Mcintosh, AM , Evans, KL, Räikkönen, K, Lahti, J, Nohr, EA, Sørensen, TIA, Hansen, T, Morgen, CS, Binder, EB, Lucae, S, Gonzalez, JR, Bustamante, M, Sunyer, J, Holloway, JW, Karmaus, W, Zhang, H, Deary, IJ, Wray, NR, Starr, JM, Beekman, M, Van Heemst, D, Slagboom, PE, Morange, P, Trégouët, D, Veldink, JH, Davies, GE, De Geus, EJC, Boomsma, DI, Vonk, JM, Brunekreef, B, Koppelman, GH, Alarcón-riquelme, ME, Huang, R, Pennell, CE, Van Meurs, J, Ikram, MA, Hughes, AD, Tillin, T, Chaturvedi, N, Pausova, Z, Paus, T, Spector, TD, Kumari, M, Schalkwyk, LC, Visscher, PM, Davey Smith, G, Bock, C, Gaunt, TR, Bell, JT, Heijmans, BT, Mill, J & Relton, CL 2021, 'Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation', Nature Genetics, vol. 53, no. 9, pp. 1311-1321. https://doi.org/10.1038/s41588-021-00923-x

TY - JOUR

T1 - Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

AU - Min, Josine L.

AU - Hemani, Gibran

AU - Hannon, Eilis

AU - Dekkers, Koen F.

AU - Castillo-fernandez, Juan

AU - Luijk, René

AU - Carnero-montoro, Elena

AU - Lawson, Daniel J.

AU - Burrows, Kimberley

AU - Suderman, Matthew

AU - Bretherick, Andrew D.

AU - Richardson, Tom G.

AU - Klughammer, Johanna

AU - Iotchkova, Valentina

AU - Sharp, Gemma

AU - Al Khleifat, Ahmad

AU - Shatunov, Aleksey

AU - Iacoangeli, Alfredo

AU - Mcardle, Wendy L.

AU - Ho, Karen M.

AU - Kumar, Ashish

AU - Söderhäll, Cilla

AU - Soriano-tárraga, Carolina

AU - Giralt-steinhauer, Eva

AU - Kazmi, Nabila

AU - Mason, Dan

AU - Mcrae, Allan F.

AU - Corcoran, David L.

AU - Sugden, Karen

AU - Kasela, Silva

AU - Cardona, Alexia

AU - Day, Felix R.

AU - Cugliari, Giovanni

AU - Viberti, Clara

AU - Guarrera, Simonetta

AU - Lerro, Michael

AU - Gupta, Richa

AU - Bollepalli, Sailalitha

AU - Mandaviya, Pooja

AU - Zeng, Yanni

AU - Clarke, Toni-kim

AU - Walker, Rosie M.

AU - Schmoll, Vanessa

AU - Czamara, Darina

AU - Ruiz-arenas, Carlos

AU - Rezwan, Faisal I.

AU - Marioni, Riccardo E.

AU - Lin, Tian

AU - Awaloff, Yvonne

AU - Germain, Marine

AU - Aïssi, Dylan

AU - Zwamborn, Ramona

AU - Van Eijk, Kristel

AU - Dekker, Annelot

AU - Van Dongen, Jenny

AU - Hottenga, Jouke-jan

AU - Willemsen, Gonneke

AU - Xu, Cheng-jian

AU - Barturen, Guillermo

AU - Català-moll, Francesc

AU - Kerick, Martin

AU - Wang, Carol

AU - Melton, Phillip

AU - Elliott, Hannah R.

AU - Shin, Jean

AU - Bernard, Manon

AU - Yet, Idil

AU - Smart, Melissa

AU - Gorrie-stone, Tyler

AU - Shaw, Chris

AU - Al Chalabi, Ammar

AU - Ring, Susan M.

AU - Pershagen, Göran

AU - Melén, Erik

AU - Jiménez-conde, Jordi

AU - Roquer, Jaume

AU - Lawlor, Deborah A.

AU - Wright, John

AU - Martin, Nicholas G.

AU - Montgomery, Grant W.

AU - Moffitt, Terrie E.

AU - Poulton, Richie

AU - Esko, Tõnu

AU - Milani, Lili

AU - Metspalu, Andres

AU - Perry, John R. B.

AU - Ong, Ken K.

AU - Wareham, Nicholas J.

AU - Matullo, Giuseppe

AU - Sacerdote, Carlotta

AU - Panico, Salvatore

AU - Caspi, Avshalom

AU - Arseneault, Louise

AU - Gagnon, France

AU - Ollikainen, Miina

AU - Kaprio, Jaakko

AU - Felix, Janine F.

AU - Rivadeneira, Fernando

AU - Tiemeier, Henning

AU - Van Ijzendoorn, Marinus H.

AU - Uitterlinden, André G.

AU - Jaddoe, Vincent W. V.

AU - Haley, Chris

AU - Mcintosh, Andrew M.

AU - Evans, Kathryn L.

AU - Räikkönen, Katri

AU - Lahti, Jari

AU - Nohr, Ellen A.

AU - Sørensen, Thorkild I. A.

AU - Hansen, Torben

AU - Morgen, Camilla S.

AU - Binder, Elisabeth B.

AU - Lucae, Susanne

AU - Gonzalez, Juan Ramon

AU - Bustamante, Mariona

AU - Sunyer, Jordi

AU - Holloway, John W.

AU - Karmaus, Wilfried

AU - Zhang, Hongmei

AU - Deary, Ian J.

AU - Wray, Naomi R.

AU - Starr, John M.

AU - Beekman, Marian

AU - Van Heemst, Diana

AU - Slagboom, P. Eline

AU - Morange, Pierre-emmanuel

AU - Trégouët, David-alexandre

AU - Veldink, Jan H.

AU - Davies, Gareth E.

AU - De Geus, Eco J. C.

AU - Boomsma, Dorret I.

AU - Vonk, Judith M.

AU - Brunekreef, Bert

AU - Koppelman, Gerard H.

AU - Alarcón-riquelme, Marta E.

AU - Huang, Rae-chi

AU - Pennell, Craig E.

AU - Van Meurs, Joyce

AU - Ikram, M. Arfan

AU - Hughes, Alun D.

AU - Tillin, Therese

AU - Chaturvedi, Nish

AU - Pausova, Zdenka

AU - Paus, Tomas

AU - Spector, Timothy D.

AU - Kumari, Meena

AU - Schalkwyk, Leonard C.

AU - Visscher, Peter M.

AU - Davey Smith, George

AU - Bock, Christoph

AU - Gaunt, Tom R.

AU - Bell, Jordana T.

AU - Heijmans, Bastiaan T.

AU - Mill, Jonathan

AU - Relton, Caroline L.

PY - 2021/9/6

Y1 - 2021/9/6

U2 - 10.1038/s41588-021-00923-x

DO - 10.1038/s41588-021-00923-x

M3 - Article

SN - 1061-4036

VL - 53

SP - 1311

EP - 1321

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -