Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand

Jemma L Geoghegan, Xiaoyun Ren, Matthew Storey, James Hadfield, Lauren Jelley, Sarah Jefferies, Jill Sherwood, Shevaun Paine, Sue Huang, Jordan Douglas, Fábio K Mendes, Andrew Sporle, Michael G Baker, David R Murdoch, Nigel French, Colin R Simpson, David Welch, Alexei J Drummond, Edward C Holmes, Sebastián DuchêneJoep de Ligt

Research output: Contribution to journalArticlepeer-review

Abstract

New Zealand, a geographically remote Pacific island with easily sealable borders, implemented a nationwide 'lockdown' of all non-essential services to curb the spread of COVID-19. Here, we generate 649 SARS-CoV-2 genome sequences from infected patients in New Zealand with samples collected during the 'first wave', representing 56% of all confirmed cases in this time period. Despite its remoteness, the viruses imported into New Zealand represented nearly all of the genomic diversity sequenced from the global virus population. These data helped to quantify the effectiveness of public health interventions. For example, the effective reproductive number, Re of New Zealand's largest cluster decreased from 7 to 0.2 within the first week of lockdown. Similarly, only 19% of virus introductions into New Zealand resulted in ongoing transmission of more than one additional case. Overall, these results demonstrate the utility of genomic pathogen surveillance to inform public health and disease mitigation.

Original languageEnglish
Pages (from-to)6351
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 11 Dec 2020

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • COVID-19/epidemiology
  • Child
  • Child, Preschool
  • Female
  • Genome, Viral/genetics
  • Genomics/methods
  • Geography
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • New Zealand/epidemiology
  • Pandemics
  • Phylogeny
  • SARS-CoV-2/classification
  • Whole Genome Sequencing/methods
  • Young Adult

Fingerprint

Dive into the research topics of 'Genomic epidemiology reveals transmission patterns and dynamics of SARS-CoV-2 in Aotearoa New Zealand'. Together they form a unique fingerprint.

Cite this