Genomic markers associated with antibody response to Newcastle disease virus of Sasso chickens raised in Ethiopia

M. Girma*, K. M. Morris, K. Sutton, W. Esatu, B. Solomon, T. Dessie, A. Psifidi, L. Vervelde, O. Hanotte, G. Banos, D. P. Malatji

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Newcastle disease virus (NDV) is one of the highly contagious avian pathogens that threatens poultry producers in endemic zones due to its epidemic potential. Selection for antibody (Ab) response can effectively improve disease resistance in chickens. However, the molecular basis of the variation in Ab response to NDV is unclear. This study aimed to detect genomic markers and genes modulating Ab response to NDV in chickens reared under tropical, outdoor conditions. A genome-wide association study (GWAS) was conducted on Sasso T451A chickens that were naturally exposed to infectious diseases from 56 to 112 days of age to identify regions associated with Ab response to NDV. Phenotypic immune data from 935 chickens, monitored in two batches, and genotyping data of these chickens based low-pass sequencing (2,676,181 single nucleotide polymorphisms, SNPs) were used. BioMart data mining and variant effect predictor tools were used to annotate SNPs and candidate genes, respectively. A total of five SNPs (rs316795557 (FOXP2), chr 1; rs313761644 (CEP170B), chr 5; rs733628728, chr 13; and two unnamed SNPs, chr 30 and chr 33) were associated with the chicken antibody response to NDV at the suggestive significance level. These SNPs are located on chromosomes 1, 5, and 13 and are in genomic regions that contain several genes with roles in the regulation of the immune response. The results of this study pave the path for more investigation into the host immune response of chickens to NDV.

Original languageEnglish
Pages (from-to)728-736
Number of pages9
JournalSouth african journal of animal science
Issue number5
Early online date28 Oct 2023
Publication statusPublished - 2023

Keywords / Materials (for Non-textual outputs)

  • antibody response
  • genome-wide association analysis
  • Newcastle disease
  • Sasso T451A
  • vaccine challenge


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