Genotype and cardiovascular phenotype: Lessons from genetically manipulated animals and diseased humans

M G F Sharp, S Kantachuvesiri, J J Mullins

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Recent advances in our understanding of the molecular genetic basis of cardiovascular diseases have been facilitated through animal models and human case studies. The identification of genes that contribute to human disease leads to functional studies of disease-associated mutations, and the use of genetically manipulated animals in these types of study are providing important insights into molecular mechanisms in vivo. This article reviews some genetically manipulated animal models of cardiovascular diseases, and their relevance to human conditions. Application of these approaches to address physiological questions is also discussed.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalCurrent Opinion in Nephrology and Hypertension
Volume6
Issue number1
Publication statusPublished - Jan 1997

Fingerprint

Dive into the research topics of 'Genotype and cardiovascular phenotype: Lessons from genetically manipulated animals and diseased humans'. Together they form a unique fingerprint.

Cite this