Genotype-level variation in lifetime breeding success, litter size and survival of sheep in scrapie-affected flocks.

Margo E Chase-Topping, Loeske E Kruuk, Daniel Lajous, Suzanne Touzeau, Louise Matthews, Geoff Simm, Jim Foster, Rachel Rupp, Francis Eychenne, Nora Hunter, Jean-Michel Elsen, Mark EJ Woolhouse

Research output: Contribution to journalArticlepeer-review

Abstract

Five different sheep flocks with natural outbreaks of scrapie were examined to determine associations between individual performance (lifetime breeding success, litter size and survival) and scrapie infection or PrP genotype. Despite different breed composition and forces of infection, consistent patterns were found among the flocks. Regardless of the flock, scrapie-infected sheep produced on average 34 % fewer offspring than non-scrapie-infected sheep. The effect of scrapie on lifetime breeding success appears to be a function of lifespan as opposed to fecundity. Analysis of litter size revealed no overall or genotype differences among the five sheep flocks. Survival, however, depends on the individual's scrapie status (infected or not) and its PrP genotype. Susceptible genotypes appear to perform less well in lifetime breeding success and life expectancy even if they are never affected with clinical scrapie. One possible explanation for these results is the effect of pre-clinical scrapie. Additional evidence supporting this hypothesis is discussed.
Original languageEnglish
Article number4
Pages (from-to)1229-38
Number of pages10
JournalJournal of General Virology
Volume86
DOIs
Publication statusPublished - Apr 2005

Keywords

  • Animals
  • breeding
  • Disease Outbreaks
  • Female
  • Genetic Variation
  • GENOTYPE
  • LITTER SIZE
  • Prions
  • SCRAPIE
  • Sheep Diseases
  • Sheep, Domestic
  • Survival Rate

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