Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: A multicentre cross-sectional study

Sema Nickbakhsh*, Carol Leitch, Shanley Smith, Chris Davis, Sharon Hutchinson, William L. Irving, John Mclauchlan, Emma C Thomson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Despite promising steps towards the elimination of Hepatitis C virus (HCV) in the UK, several indicators provide a cause for concern for future disease burden. We aimed to improve understanding of geographical variation in HCV-related severe liver disease and historic risk factor prevalence among clinic attendees in England and Scotland. We used metadata from 3,829 HCV-positive patients consecutively enrolled into HCV Research UK from 48 hospital centres in England and Scotland during 2012-2014. Employing mixedeffects statistical modelling, several independent risk factors were identified: age 46-59y (ORadj=3.06) and ≥60y (ORadj=5.64) relative to
Original languageEnglish
Article numbere59
Pages (from-to)1-33
Number of pages32
JournalEpidemiology & Infection
Volume151
Early online date14 Mar 2023
DOIs
Publication statusPublished - 14 Mar 2023

Keywords / Materials (for Non-textual outputs)

  • viral hepatitis
  • cirrhosis
  • risk maps
  • public health

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