Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: A multicentre cross-sectional study

Sema Nickbakhsh; Carol Leitch; Shanley Smith; Chris Davis; Sharon Hutchinson; William L. Irving; John Mclauchlan; Emma C Thomson

doi:10.1017/S0950268823000377

Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: A multicentre cross-sectional study

Sema Nickbakhsh^*, Carol Leitch, Shanley Smith, Chris Davis, Sharon Hutchinson, William L. Irving, John Mclauchlan, Emma C Thomson^*

^*Corresponding author for this work

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Despite promising steps towards the elimination of Hepatitis C virus (HCV) in the UK, several indicators provide a cause for concern for future disease burden. We aimed to improve understanding of geographical variation in HCV-related severe liver disease and historic risk factor prevalence among clinic attendees in England and Scotland. We used metadata from 3,829 HCV-positive patients consecutively enrolled into HCV Research UK from 48 hospital centres in England and Scotland during 2012-2014. Employing mixedeffects statistical modelling, several independent risk factors were identified: age 46-59y (ORadj=3.06) and ≥60y (ORadj=5.64) relative to

Original language	English
Article number	e59
Pages (from-to)	1-33
Number of pages	32
Journal	Epidemiology & Infection
Volume	151
Early online date	14 Mar 2023
DOIs	https://doi.org/10.1017/S0950268823000377
Publication status	Published - 14 Mar 2023

Keywords / Materials (for Non-textual outputs)

viral hepatitis
cirrhosis
risk maps
public health

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title = "Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: A multicentre cross-sectional study",

abstract = "Despite promising steps towards the elimination of Hepatitis C virus (HCV) in the UK, several indicators provide a cause for concern for future disease burden. We aimed to improve understanding of geographical variation in HCV-related severe liver disease and historic risk factor prevalence among clinic attendees in England and Scotland. We used metadata from 3,829 HCV-positive patients consecutively enrolled into HCV Research UK from 48 hospital centres in England and Scotland during 2012-2014. Employing mixedeffects statistical modelling, several independent risk factors were identified: age 46-59y (ORadj=3.06) and ≥60y (ORadj=5.64) relative to ",

keywords = "viral hepatitis, cirrhosis, risk maps, public health",

author = "Sema Nickbakhsh and Carol Leitch and Shanley Smith and Chris Davis and Sharon Hutchinson and Irving, \{William L.\} and John Mclauchlan and Thomson, \{Emma C\}",

year = "2023",

month = mar,

day = "14",

doi = "10.1017/S0950268823000377",

language = "English",

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journal = "Epidemiology \& Infection",

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T1 - Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: A multicentre cross-sectional study

AU - Nickbakhsh, Sema

AU - Leitch, Carol

AU - Smith, Shanley

AU - Davis, Chris

AU - Hutchinson, Sharon

AU - Irving, William L.

AU - Mclauchlan, John

AU - Thomson, Emma C

PY - 2023/3/14

Y1 - 2023/3/14

N2 - Despite promising steps towards the elimination of Hepatitis C virus (HCV) in the UK, several indicators provide a cause for concern for future disease burden. We aimed to improve understanding of geographical variation in HCV-related severe liver disease and historic risk factor prevalence among clinic attendees in England and Scotland. We used metadata from 3,829 HCV-positive patients consecutively enrolled into HCV Research UK from 48 hospital centres in England and Scotland during 2012-2014. Employing mixedeffects statistical modelling, several independent risk factors were identified: age 46-59y (ORadj=3.06) and ≥60y (ORadj=5.64) relative to

AB - Despite promising steps towards the elimination of Hepatitis C virus (HCV) in the UK, several indicators provide a cause for concern for future disease burden. We aimed to improve understanding of geographical variation in HCV-related severe liver disease and historic risk factor prevalence among clinic attendees in England and Scotland. We used metadata from 3,829 HCV-positive patients consecutively enrolled into HCV Research UK from 48 hospital centres in England and Scotland during 2012-2014. Employing mixedeffects statistical modelling, several independent risk factors were identified: age 46-59y (ORadj=3.06) and ≥60y (ORadj=5.64) relative to

KW - viral hepatitis

KW - cirrhosis

KW - risk maps

KW - public health

U2 - 10.1017/S0950268823000377

DO - 10.1017/S0950268823000377

M3 - Article

C2 - 36915219

SN - 0950-2688

VL - 151

SP - 1

EP - 33

JO - Epidemiology & Infection

JF - Epidemiology & Infection

M1 - e59

ER -

Geographical variation in Hepatitis C-related severe liver disease and patient risk factors: A multicentre cross-sectional study

Abstract

Keywords / Materials (for Non-textual outputs)

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