Projects per year
Abstract / Description of output
Due to the highly orchestrated stages of mitosis, cells segregate their chromosomes with incredibly high fidelity. One of the principal 'conductors' is the spindle checkpoint, which regulates mitotic progression. Specifically, it delays anaphase onset until all chromosomes are attached in a bi-oriented fashion to spindle microtubules. This delay stems from inhibition of Cdc20, an activator of an E3 ubiquitin ligase known as the anaphase-promoting complex or cyclosome (APC/C). Several recent advances in our mechanistic understanding of this important cell cycle control have been made. Although still poorly understood, signalling roles for checkpoint kinases and their opposing phosphatases continue to be uncovered, and the key substrates gradually identified.
Original language | English |
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Pages (from-to) | 18-27 |
Number of pages | 10 |
Journal | Trends in biochemical sciences |
Volume | 35 |
Issue number | 1 |
Early online date | 20 Oct 2009 |
DOIs | |
Publication status | Published - 1 Jan 2010 |
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Dive into the research topics of 'Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling'. Together they form a unique fingerprint.Projects
- 1 Finished
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The spindle checkpoint: co-ordination of mitotic progression with chromosome segregation
1/01/08 → 31/12/13
Project: Research