Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling

Judith Zich, Kevin G Hardwick

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Due to the highly orchestrated stages of mitosis, cells segregate their chromosomes with incredibly high fidelity. One of the principal 'conductors' is the spindle checkpoint, which regulates mitotic progression. Specifically, it delays anaphase onset until all chromosomes are attached in a bi-oriented fashion to spindle microtubules. This delay stems from inhibition of Cdc20, an activator of an E3 ubiquitin ligase known as the anaphase-promoting complex or cyclosome (APC/C). Several recent advances in our mechanistic understanding of this important cell cycle control have been made. Although still poorly understood, signalling roles for checkpoint kinases and their opposing phosphatases continue to be uncovered, and the key substrates gradually identified.
Original languageEnglish
Pages (from-to)18-27
Number of pages10
JournalTrends in biochemical sciences
Issue number1
Early online date20 Oct 2009
Publication statusPublished - 1 Jan 2010


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