Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour

Mark R Morgan, Adam Byron, Martin J Humphries, Mark D Bass

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, alpha(v)beta(3) and alpha(5)beta(1) integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated.

Original languageEnglish
Pages (from-to)731-8
JournalIubmb life
Volume61
Issue number7
Early online date9 Jun 2009
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

Keywords

  • Cell Adhesion
  • Cell Movement
  • Gene Expression Regulation
  • Humans
  • Integrin alpha5beta1
  • Integrin alphaVbeta3
  • Membrane Microdomains
  • Protein Transport
  • Receptors, Fibronectin
  • Signal Transduction
  • rac1 GTP-Binding Protein

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