Glial cell development and function in zebrafish

David A Lyons, William S Talbot

Research output: Contribution to journalLiterature reviewpeer-review


The zebrafish is a premier vertebrate model system that offers many experimental advantages for in vivo imaging and genetic studies. This review provides an overview of glial cell types in the central and peripheral nervous system of zebrafish. We highlight some recent work that exploited the strengths of the zebrafish system to increase the understanding of the role of Gpr126 in Schwann cell myelination and illuminate the mechanisms controlling oligodendrocyte development and myelination. We also summarize similarities and differences between zebrafish radial glia and mammalian astrocytes and consider the possibility that their distinct characteristics may represent extremes in a continuum of cell identity. Finally, we focus on the emergence of zebrafish as a model for elucidating the development and function of microglia. These recent studies have highlighted the power of the zebrafish system for analyzing important aspects of glial development and function.

Original languageEnglish
Pages (from-to)a020586
JournalCold Spring Harbor perspectives in biology
Issue number2
Publication statusPublished - Feb 2015


  • Animals
  • Astrocytes
  • Cell Differentiation
  • Cell Lineage
  • Mammals
  • Myelin Sheath
  • Neuroglia
  • Oligodendroglia
  • Receptors, G-Protein-Coupled
  • Schwann Cells
  • Zebrafish
  • Zebrafish Proteins

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