Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

neuroCHARGE Cognitive Working group; ENIGMA Consortium

doi:10.1093/cercor/bhaa035

Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

neuroCHARGE Cognitive Working group, ENIGMA Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

We have carried out meta-analyses of genome-wide association studies (n=23,784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25,746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that inter-individual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade – albeit in a very limited manner – to behaviours as complex as the choice of one’s occupation.

Original language	English
Article number	bhaa035
Journal	Cerebral Cortex
Early online date	20 Mar 2020
DOIs	https://doi.org/10.1093/cercor/bhaa035
Publication status	E-pub ahead of print - 20 Mar 2020

Keywords / Materials (for Non-textual outputs)

brain development
cortical surface area
cortical thickness
genomeide association study
occupational aptitude

Access to Document

10.1093/cercor/bhaa035

ShinEtalCC2020GlobalAndregionalDevelopmentOfTheHuman
This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Jean Shin etal, for the neuroCHARGE Working Group, Global and Regional Development of the Human Cerebral Cortex: Molecular Architecture and Occupational Aptitudes, Cerebral Cortex, bhaa035, https://doi.org/10.1093/cercor/bhaa035 is available online at: https://academic.oup.com/cercor/advance-article/doi/10.1093/cercor/bhaa035/5810465?searchresult=1
Accepted author manuscript, 9.55 MB

The Disconnected Mind Phase 3
Cox, S. (Principal Investigator) & Deary, I. (Co-investigator)
1/04/16 → 31/03/23
Project: Research
Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J. (Principal Investigator), Bastin, M. (Co-investigator) & Deary, I. (Co-investigator)
MRC
1/05/15 → 30/04/19
Project: Research
RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Wardlaw, J. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research

Joanna Wardlaw
- joanna.wardlawed.acuk
- Deanery of Clinical Sciences - Personal Chair Applied Neuroimaging
- Centre for Clinical Brain Sciences
- Edinburgh Neuroscience
- Edinburgh Imaging
- Small Vessel Disease Research
- Cerebrovascular Research Group
Person: Academic: Research Active

Cite this

@article{6ad722a7b66b41358ec7314f1b3901a8,

title = "Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes",

abstract = "We have carried out meta-analyses of genome-wide association studies (n=23,784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25,746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that inter-individual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade – albeit in a very limited manner – to behaviours as complex as the choice of one{\textquoteright}s occupation.",

keywords = "brain development, cortical surface area, cortical thickness, genomeide association study, occupational aptitude",

author = "{neuroCHARGE Cognitive Working group} and Jean Shin and Shaojie Ma and Edith Hofer and Yash Patel and Daniel Vosberg and Steven Tilley and Roshchupkin, {Gennady V.} and Andr{\'e} Sousa and Xueqiu Jian and Gottesman, {Rebecca F} and Mosley, {Thomas H} and Myriam Fornage and Yasaman Saba and Lukas Pirpamer and Reinhold Schmidt and Helena Schmidt and Amaia Carrion-Castillo and Fabrice Crivello and Bernard Mazoyer and Bis, {Joshua C.} and Shuo Li and Qiong Yang and Michelle Luciano and Sherif Karama and Lindsay Lewis and Mark Bastin and Mat Harris and Joanna Wardlaw and Ian Deary and Markus Scholz and Markus Loeffler and Witte, {A. Veronica} and Frauke Beyer and Arno Villringer and Armstrong, {Nicola J} and Mather, {Karen A} and David Ames and Jiyang Jiang and Kwok, {John B J} and Schofield, {Peter R} and Anbupalam Thalamuthu and Trollor, {Julian N.} and Wright, {Margaret J} and Henry Brodaty and Wei Wen and Sachdev, {Perminder S} and Natalie Terzikhan and Evans, {Tavia E} and Adams, {Hieab H H} and Ikram, {M Arfan} and Stefan Frenzel and {van der Auwera-Palitschka}, Sandra and Katharina Wittfeld and Robin B{\"u}low and Grabe, {Hans J{\"o}rgen} and Christophe Tzourio and Aniket Mishra and Sophie Maingault and St{\'e}phanie Debette and Nathan Gillespie and Franz, {Carol E.} and Kremen, {William S.} and Linda Ding and Neda Jahanshad and {ENIGMA Consortium} and Nenad Sestan and Zdenka Pausova and Sudha Seshadri",

year = "2020",

month = mar,

day = "20",

doi = "10.1093/cercor/bhaa035",

language = "English",

journal = "Cerebral Cortex",

issn = "1047-3211",

publisher = "Oxford University Press",

}

TY - JOUR

T1 - Global and regional development of the human cerebral cortex

T2 - Molecular architecture and occupational aptitudes

AU - neuroCHARGE Cognitive Working group

AU - Shin, Jean

AU - Ma, Shaojie

AU - Hofer, Edith

AU - Patel, Yash

AU - Vosberg, Daniel

AU - Tilley, Steven

AU - Roshchupkin, Gennady V.

AU - Sousa, André

AU - Jian, Xueqiu

AU - Gottesman, Rebecca F

AU - Mosley, Thomas H

AU - Fornage, Myriam

AU - Saba, Yasaman

AU - Pirpamer, Lukas

AU - Schmidt, Reinhold

AU - Schmidt, Helena

AU - Carrion-Castillo, Amaia

AU - Crivello, Fabrice

AU - Mazoyer, Bernard

AU - Bis, Joshua C.

AU - Li, Shuo

AU - Yang, Qiong

AU - Luciano, Michelle

AU - Karama, Sherif

AU - Lewis, Lindsay

AU - Bastin, Mark

AU - Harris, Mat

AU - Wardlaw, Joanna

AU - Deary, Ian

AU - Scholz, Markus

AU - Loeffler, Markus

AU - Witte, A. Veronica

AU - Beyer, Frauke

AU - Villringer, Arno

AU - Armstrong, Nicola J

AU - Mather, Karen A

AU - Ames, David

AU - Jiang, Jiyang

AU - Kwok, John B J

AU - Schofield, Peter R

AU - Thalamuthu, Anbupalam

AU - Trollor, Julian N.

AU - Wright, Margaret J

AU - Brodaty, Henry

AU - Wen, Wei

AU - Sachdev, Perminder S

AU - Terzikhan, Natalie

AU - Evans, Tavia E

AU - Adams, Hieab H H

AU - Ikram, M Arfan

AU - Frenzel, Stefan

AU - van der Auwera-Palitschka, Sandra

AU - Wittfeld, Katharina

AU - Bülow, Robin

AU - Grabe, Hans Jörgen

AU - Tzourio, Christophe

AU - Mishra, Aniket

AU - Maingault, Sophie

AU - Debette, Stéphanie

AU - Gillespie, Nathan

AU - Franz, Carol E.

AU - Kremen, William S.

AU - Ding, Linda

AU - Jahanshad, Neda

AU - ENIGMA Consortium

AU - Sestan, Nenad

AU - Pausova, Zdenka

AU - Seshadri, Sudha

PY - 2020/3/20

Y1 - 2020/3/20

N2 - We have carried out meta-analyses of genome-wide association studies (n=23,784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25,746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that inter-individual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade – albeit in a very limited manner – to behaviours as complex as the choice of one’s occupation.

AB - We have carried out meta-analyses of genome-wide association studies (n=23,784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25,746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that inter-individual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade – albeit in a very limited manner – to behaviours as complex as the choice of one’s occupation.

KW - brain development

KW - cortical surface area

KW - cortical thickness

KW - genomeide association study

KW - occupational aptitude

U2 - 10.1093/cercor/bhaa035

DO - 10.1093/cercor/bhaa035

M3 - Article

SN - 1047-3211

JO - Cerebral Cortex

JF - Cerebral Cortex

M1 - bhaa035

ER -

Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

The Disconnected Mind Phase 3

Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

Profiles

Joanna Wardlaw

Cite this