Projects per year
Abstract / Description of output
We have carried out meta-analyses of genome-wide association studies (n=23,784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25,746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that inter-individual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade – albeit in a very limited manner – to behaviours as complex as the choice of one’s occupation.
Original language | English |
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Article number | bhaa035 |
Journal | Cerebral Cortex |
Early online date | 20 Mar 2020 |
DOIs | |
Publication status | E-pub ahead of print - 20 Mar 2020 |
Keywords / Materials (for Non-textual outputs)
- brain development
- cortical surface area
- cortical thickness
- genomeide association study
- occupational aptitude
Fingerprint
Dive into the research topics of 'Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes'. Together they form a unique fingerprint.Projects
- 6 Finished
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Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III
Wardlaw, J., Bastin, M. & Deary, I.
1/05/15 → 30/04/19
Project: Research
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RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
1/09/13 → 31/08/19
Project: Research
Profiles
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Joanna Wardlaw
- Deanery of Clinical Sciences - Personal Chair Applied Neuroimaging
- Centre for Clinical Brain Sciences
- Edinburgh Neuroscience
- Edinburgh Imaging
- Small Vessel Disease Research
- Cerebrovascular Research Group
Person: Academic: Research Active