Global application of therapeutic hypothermia to treat perinatal asphyxial encephalopathy

Sudhin Thayyil, Zulfiqar A Bhutta, Siddarth Ramji, Anthony M Costello, Nicola J Robertson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Therapeutic hypothermia improves neurodevelopmental outcome following perinatal asphyxial encephalopathy and has now become 'standard of care' in industrialised countries. However, none of the cooling trials so far have been conducted in developing countries, where approximately one million asphyxial deaths occur every year. Use of therapeutic hypothermia in such settings raises several clinical, pragmatic and ethical issues. We suggest that rigorous clinical trials of cooling are required to ensure that a safe and effective neuroprotective therapy demonstrated in high resource settings does not become an unsafe and ineffective practice in low resource settings.

Original languageEnglish
Pages (from-to)79-81
Number of pages3
JournalInternational Health
Issue number2
Publication statusPublished - Jun 2010


Dive into the research topics of 'Global application of therapeutic hypothermia to treat perinatal asphyxial encephalopathy'. Together they form a unique fingerprint.

Cite this