Global gene expression analysis of chicken caecal response to Campylobacter jejuni

Ronan G Shaughnessy, Kieran G Meade, Beatrice A McGivney, Brenda Allan, Cliona O'Farrelly

Research output: Contribution to journalArticlepeer-review

Abstract

Campylobacter jejuni colonises the caecum of more than 90% of commercial chickens. Even though colonisation is asymptomatic, we hypothesised that it is mediated by activation of several biological pathways. We therefore used chicken-specific 20K oligonucleotide microarrays to examine global gene expression in C. jejuni-challenged birds. Microarray results demonstrate small but significant fold-changes in expression of 270 genes 20 h post-challenge, corresponding to a wide range of biological processes including cell growth, nutrient metabolism and immunological activity. Expression of NOX1 (2.3-fold) and VCAM1 (1.5-fold) were significantly increased in colonised birds (P
Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalVeterinary Immunology and Immunopathology
Volume142
Issue number1-2
DOIs
Publication statusPublished - 15 Jul 2011

Keywords

  • Animals
  • Campylobacter Infections
  • Campylobacter jejuni
  • Cecum
  • Chickens
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Genes
  • Immunity
  • Oligonucleotide Array Sequence Analysis
  • Poultry Diseases

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