GluA2-dependent AMPA receptor endocytosis and the decay of early and late long-term potentiation: possible mechanisms for forgetting of short- and long-term memories

Oliver Hardt*, Karim Nader, Yu-Tian Wang

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The molecular processes involved in establishing long-term potentiation (LTP) have been characterized well, but the decay of early and late LTP (E-LTP and L-LTP) is poorly understood. We review recent advances in describing the mechanisms involved in maintaining LTP and homeostatic plasticity. We discuss how these phenomena could relate to processes that might underpin the loss of synaptic potentiation over time, and how they might contribute to the forgetting of short-term and long-term memories. We propose that homeostatic downscaling mediates the loss of E-LTP, and that metaplastic parameters determine the decay rate of L-LTP, while both processes require the activity-dependent removal of postsynaptic GluA2-containing AMPA receptors.

Original languageEnglish
Article number20130141
Number of pages9
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume369
Issue number1633
DOIs
Publication statusPublished - 5 Jan 2014

Keywords

  • long-term potentiation
  • decay
  • homeostatic scaling
  • metaplasticity
  • forgetting
  • KINASE M-ZETA
  • HIPPOCAMPAL SYNAPTIC PLASTICITY
  • PKM-ZETA
  • NMDA RECEPTORS
  • SPATIAL MEMORY
  • VISUAL-CORTEX
  • TYROSINE PHOSPHORYLATION
  • PROTEIN-SYNTHESIS
  • SUBUNIT GLUR2
  • FEAR MEMORY

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