GLUCOCORTICOID RECEPTOR AND NGFI-A GENE-EXPRESSION ARE INDUCED IN THE HIPPOCAMPUS AFTER ENVIRONMENTAL ENRICHMENT IN ADULT-RATS

T OLSSON, A H MOHAMMED, L F DONALDSON, B G HENRIKSSON, J R SECKL

Research output: Contribution to journalComment/debatepeer-review

Abstract

Environmental manipulation alters hippocampal glucocorticoid receptor (GR) expression in neonatal rats, but effects in adults have not been documented. Chronic environmental enrichment (EE) increases nerve-growth factor (NGF) concentrations in the adult rat hippocampus. Here we demonstrate that EE induces GR, but not mineralocorticoid receptor (MR) gene expression in specific hippocampal subfields (CA1 and CA2). This is accompanied by increased expression of mRNA encoding the (NGF-induced) immediate early gene NGFI-A in CA2, whereas expression of NGFI-B mRNA decreased in CA1 and CA2. The nature of any relationship between NGF, the transcription factors and GR remains to be determined, but the results demonstrate that chronic environmental manipulations alter hippocampal GR gene expression in adult rats.

Original languageEnglish
Pages (from-to)349-353
Number of pages5
JournalMolecular brain research
Volume23
Issue number4
Publication statusPublished - Jun 1994

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