Glucocorticoids and the prenatal programming of neurodevelopmental disorders

Jessy Cartier, Yan Zeng, Amanda J Drake

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Synthetic glucocorticoids are frequently used antenatally in order to reduce morbidity and mortality in babies born preterm and have been used in the management of fetuses known to be at risk of congenital adrenal hyperplasia. Although such treatment has short term advantages, evidence suggests that it can affect health in later life. Several studies have reported negative consequences of prenatal exposure to the synthetic glucocorticoid dexamethasone on offspring behaviour in humans and in animal models, in association with changes in brain structure, hypothalamic-pituitary-adrenal axis function, neurotransmitter pathways, gene transcription and epigenetic regulation. These studies also highlight the importance of timing and tissue/organ- and sex-specific effects of prenatal glucocorticoid exposure. Here we review the evidence from human and animal studies that links prenatal synthetic glucocorticoid exposure with an increased risk for neurodevelopmental disorders.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCurrent Opinion in Behavioral Sciences
Volume7
Early online date19 Aug 2015
DOIs
Publication statusPublished - 2015

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