Projects per year
Glucocorticoids are essential in mammals to mature fetal organs and tissues in order to survive after birth. Hence, antenatal glucocorticoid treatment (termed antenatal corticosteroid therapy) can be life-saving in preterm babies and is commonly used in women at risk of preterm birth. While the effects of glucocorticoids on lung maturation have been well described, the effects on the fetal heart remain less clear. Experiments in mice have shown that endogenous glucocorticoid action is required to mature the fetal heart. However, whether the potent synthetic glucocorticoids used in antenatal corticosteroid therapy have similar maturational effects on the fetal heart is less clear. Moreover, antenatal corticosteroid therapy may increase the risk of cardiovascular disease in adulthood. Here, we present a narrative review of the evidence relating to the effects of antenatal glucocorticoid action on the fetal heart and discuss the implications for antenatal corticosteroid therapy.
|Journal||Journal of molecular endocrinology|
|Early online date||2 May 2018|
|Publication status||Published - 1 Jul 2018|
FingerprintDive into the research topics of 'Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation'. Together they form a unique fingerprint.
Medicines in pregnancy: predicting harms and benefits of antenatal corticosteroids
1/06/18 → 31/05/23
GLUCOCORTICOID RECEPTOR IN THE EARLY LIFE PROGRAMMING OF CARDIAC RESILIANCE
Chapman, K., Denvir, M., Gray, G. & Holmes, M.
1/12/16 → 30/11/19
Studentship for Callum Davidson
1/10/13 → 30/09/17