GLYCYRRHETINIC ACID, AN INHIBITOR OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE, ALTERS LOCAL CEREBRAL GLUCOSE-UTILIZATION INVIVO

J R SECKL, P A T KELLY, J SHARKEY

Research output: Contribution to journalComment/debatepeer-review

Abstract

11-beta-Hydroxysteroid dehydrogenase (11-beta-OHSD) metabolizes corticosterone (B) to inactive 11-dehydrocorticosterone and thus protects the non-specific renal mineralocorticoid receptor from exposure to B in vivo. There is regional 11-beta-OHSD mRNA expression and bioactivity in brain in vitro, but any in vivo function is unknown. We used the [C-14]2-deoxyglucose technique in conscious rats to investigate whether 11-beta-OHSD inhibition with glycyrrhetinic acid alters local cerebral metabolic activity. We found increased glucose use in subregions of the hypothalamus, hippocampus, neocortex and subthalamus. Thus, 11-beta-OHSD may play a role in regulating the effects of B in the brain, in vivo.

Original languageEnglish
Pages (from-to)777-779
Number of pages3
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume39
Issue number5A
Publication statusPublished - Nov 1991

Cite this