Gold-Triggered Uncaging Chemistry in Living Systems

Ana M Perez-Lopez, Belen Rubio Ruiz, Victor Sebastian, Lloyd Hamilton, Catherine Adam, Thomas L Bray, Silvia Irusta, Paul M Brennan, Guy C Lloyd-Jones, Dirk Sieger, J. Santamaria, Asier Unciti-Broceta

Research output: Contribution to journalArticlepeer-review

Abstract

Recent advances in bioorthogonal catalysis are increasing our capacity to manipulate the fate of molecules in complex biological systems. Herein we report a novel bioorthogonal uncaging strategy that is triggered by heterogeneous gold catalysis andfacilitates the activation of a structurally-diverse range of therapeutics in cancer cell culture. Furthermore, this solid supported catalytic system enabled —for the first time— the locally-controlled release of a fluorescent dye in the brain of a zebrafish, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.
Original languageEnglish
Pages (from-to)12722-12726
Number of pages5
JournalAngewandte Chemie
Volume129
Issue number41
Early online date12 Jul 2017
DOIs
Publication statusPublished - 2 Oct 2017

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