Good Laboratory Practice Preventing Introduction of Bias at the Bench

Malcolm R. Macleod, Marc Fisher, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M. W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, David W. Howells

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)

Original languageEnglish
Pages (from-to)E50-E52
Number of pages3
JournalStroke
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 2009

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