Good Laboratory Practice Preventing Introduction of Bias at the Bench

Malcolm R. Macleod; Marc Fisher; Victoria O'Collins; Emily S. Sena; Ulrich Dirnagl; Philip M. W. Bath; Alistair Buchan; H. Bart van der Worp; Richard Traystman; Kazuo Minematsu; Geoffrey A. Donnan; David W. Howells

doi:10.1161/STROKEAHA.108.525386

Good Laboratory Practice Preventing Introduction of Bias at the Bench

Malcolm R. Macleod, Marc Fisher, Victoria O'Collins, Emily S. Sena, Ulrich Dirnagl, Philip M. W. Bath, Alistair Buchan, H. Bart van der Worp, Richard Traystman, Kazuo Minematsu, Geoffrey A. Donnan, David W. Howells

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.

Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.

Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)

Original language	English
Pages (from-to)	E50-E52
Number of pages	3
Journal	Stroke
Volume	40
Issue number	3
DOIs	https://doi.org/10.1161/STROKEAHA.108.525386
Publication status	Published - Mar 2009

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title = "Good Laboratory Practice Preventing Introduction of Bias at the Bench",

abstract = "Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)",

author = "Macleod, {Malcolm R.} and Marc Fisher and Victoria O'Collins and Sena, {Emily S.} and Ulrich Dirnagl and Bath, {Philip M. W.} and Alistair Buchan and {van der Worp}, {H. Bart} and Richard Traystman and Kazuo Minematsu and Donnan, {Geoffrey A.} and Howells, {David W.}",

year = "2009",

month = mar,

doi = "10.1161/STROKEAHA.108.525386",

language = "English",

volume = "40",

pages = "E50--E52",

journal = "Stroke",

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TY - JOUR

T1 - Good Laboratory Practice Preventing Introduction of Bias at the Bench

AU - Macleod, Malcolm R.

AU - Fisher, Marc

AU - O'Collins, Victoria

AU - Sena, Emily S.

AU - Dirnagl, Ulrich

AU - Bath, Philip M. W.

AU - Buchan, Alistair

AU - van der Worp, H. Bart

AU - Traystman, Richard

AU - Minematsu, Kazuo

AU - Donnan, Geoffrey A.

AU - Howells, David W.

PY - 2009/3

Y1 - 2009/3

N2 - Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)

AB - Background and Purpose - As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke.Summary of Review - Accumulating evidence suggests this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments which create a systematic bias resulting in the overstatement of neuroprotective efficacy.Conclusions - Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke. (Stroke. 2009; 40: e50-e52.)

U2 - 10.1161/STROKEAHA.108.525386

DO - 10.1161/STROKEAHA.108.525386

M3 - Article

VL - 40

SP - E50-E52

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 3

ER -

Good Laboratory Practice Preventing Introduction of Bias at the Bench

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