GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

Ernestina M. De Francesco, Andrew H. Sims, Marcello Maggiolini, Federica Sotgia, Michael P. Lisanti, Robert B. Clarke

Research output: Contribution to journalArticlepeer-review

Abstract

The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional target of hypoxia inducible factor 1 alpha (HIF-1α) and activates VEGF expression and angiogenesis in hypoxic breast tumor microenvironment. Furthermore, IGF1/IGF1R signaling, which has angiogenic effects, has been shown to activate GPER in breast cancer cells.
Original languageEnglish
JournalBreast Cancer Research
Volume19
Issue number1
DOIs
Publication statusPublished - 6 Dec 2017

Keywords

  • GPER
  • VEGF
  • HIf-1A
  • Breast Cancer
  • Tumor microenvironment
  • Tumor angiogenesis
  • GPCRs
  • Growth factor receptors

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