GPX-Macrophage Expression Atlas: a database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults

Graeme R Grimes, Stuart Moodie, John S Beattie, Marie Craigon, Paul Dickinson, Thorsten Forster, Andrew D Livingston, Muriel Mewissen, Kevin A Robertson, Alan J Ross, Garwin Sing, Peter Ghazal

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophages play an integral role in the host immune system, bridging innate and adaptive immunity. As such, they are finely attuned to extracellular and intracellular stimuli and respond by rapidly initiating multiple signalling cascades with diverse effector functions. The macrophage cell is therefore an experimentally and clinically amenable biological system for the mapping of biological pathways. The goal of the macrophage expression atlas is to systematically investigate the pathway biology and interaction network of macrophages challenged with a variety of insults, in particular via infection and activation with key inflammatory mediators. As an important first step towards this we present a single searchable database resource containing high-throughput macrophage gene expression studies.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBMC Genomics
Volume6
Issue number178
DOIs
Publication statusPublished - 12 Dec 2005

Keywords

  • Animals
  • Computational Biology
  • Data Collection
  • Databases, Genetic
  • Gene Expression Profiling
  • Humans
  • Macrophages
  • Microarray Analysis
  • Quality Control
  • Research Design
  • Software Design

Fingerprint

Dive into the research topics of 'GPX-Macrophage Expression Atlas: a database for expression profiles of macrophages challenged with a variety of pro-inflammatory, anti-inflammatory, benign and pathogen insults'. Together they form a unique fingerprint.

Cite this