Grading of breast cancer on needle core biopsy: does a reduction in mitotic count threshold improve agreement with grade on excised specimens?

Catharine Ann Dhaliwal; Catriona Graham; Joseph Loane

doi:10.1136/jclinpath-2014-202294

Grading of breast cancer on needle core biopsy: does a reduction in mitotic count threshold improve agreement with grade on excised specimens?

Catharine Ann Dhaliwal, Catriona Graham, Joseph Loane

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment.

AIM: To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it.

METHODS: Pathology slides from patients with an NCB diagnosis of invasive breast cancer who underwent subsequent breast conservation surgery in 2012 were reviewed. Mitotic counts were assessed and tumour grade agreement between NCB and excision evaluated. The mitotic count thresholds were altered and grade agreement was reassessed.

RESULTS: In 283/359 (79%) cases, there was concurrence on histological grade between NCB and excision. Reduction in mitotic count thresholds did not improve either overall tumour grade agreement or agreement within any subgroup of patients.

CONCLUSIONS: In our experience, the current mitotic count score thresholds are appropriate and should be maintained.

Original language	English
Pages (from-to)	1106-8
Number of pages	3
Journal	Journal of Clinical Pathology
Volume	67
Issue number	12
DOIs	https://doi.org/10.1136/jclinpath-2014-202294
Publication status	Published - Dec 2014

Keywords / Materials (for Non-textual outputs)

Aged
Biopsy, Large-Core Needle
Breast Neoplasms
Carcinoma, Ductal, Breast
Female
Humans
Middle Aged
Mitotic Index
Neoplasm Grading

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10.1136/jclinpath-2014-202294

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@article{89dadf03f94440b4a8f1f51461a7ae37,

title = "Grading of breast cancer on needle core biopsy: does a reduction in mitotic count threshold improve agreement with grade on excised specimens?",

abstract = "BACKGROUND: Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment.AIM: To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it.METHODS: Pathology slides from patients with an NCB diagnosis of invasive breast cancer who underwent subsequent breast conservation surgery in 2012 were reviewed. Mitotic counts were assessed and tumour grade agreement between NCB and excision evaluated. The mitotic count thresholds were altered and grade agreement was reassessed.RESULTS: In 283/359 (79%) cases, there was concurrence on histological grade between NCB and excision. Reduction in mitotic count thresholds did not improve either overall tumour grade agreement or agreement within any subgroup of patients.CONCLUSIONS: In our experience, the current mitotic count score thresholds are appropriate and should be maintained.",

keywords = "Aged, Biopsy, Large-Core Needle, Breast Neoplasms, Carcinoma, Ductal, Breast, Female, Humans, Middle Aged, Mitotic Index, Neoplasm Grading",

author = "Dhaliwal, {Catharine Ann} and Catriona Graham and Joseph Loane",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2014",

month = dec,

doi = "10.1136/jclinpath-2014-202294",

language = "English",

volume = "67",

pages = "1106--8",

journal = "Journal of Clinical Pathology",

issn = "0021-9746",

publisher = "BMJ Publishing Group",

number = "12",

}

TY - JOUR

T1 - Grading of breast cancer on needle core biopsy

T2 - does a reduction in mitotic count threshold improve agreement with grade on excised specimens?

AU - Dhaliwal, Catharine Ann

AU - Graham, Catriona

AU - Loane, Joseph

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/12

Y1 - 2014/12

N2 - BACKGROUND: Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment.AIM: To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it.METHODS: Pathology slides from patients with an NCB diagnosis of invasive breast cancer who underwent subsequent breast conservation surgery in 2012 were reviewed. Mitotic counts were assessed and tumour grade agreement between NCB and excision evaluated. The mitotic count thresholds were altered and grade agreement was reassessed.RESULTS: In 283/359 (79%) cases, there was concurrence on histological grade between NCB and excision. Reduction in mitotic count thresholds did not improve either overall tumour grade agreement or agreement within any subgroup of patients.CONCLUSIONS: In our experience, the current mitotic count score thresholds are appropriate and should be maintained.

AB - BACKGROUND: Accurate assessment of invasive breast cancer grade on needle core biopsy (NCB) is important as it guides treatment.AIM: To assess the agreement between grade of invasive cancer on NCB and excision and determine whether altering the mitotic count score threshold on NCB improves it.METHODS: Pathology slides from patients with an NCB diagnosis of invasive breast cancer who underwent subsequent breast conservation surgery in 2012 were reviewed. Mitotic counts were assessed and tumour grade agreement between NCB and excision evaluated. The mitotic count thresholds were altered and grade agreement was reassessed.RESULTS: In 283/359 (79%) cases, there was concurrence on histological grade between NCB and excision. Reduction in mitotic count thresholds did not improve either overall tumour grade agreement or agreement within any subgroup of patients.CONCLUSIONS: In our experience, the current mitotic count score thresholds are appropriate and should be maintained.

KW - Aged

KW - Biopsy, Large-Core Needle

KW - Breast Neoplasms

KW - Carcinoma, Ductal, Breast

KW - Female

KW - Humans

KW - Middle Aged

KW - Mitotic Index

KW - Neoplasm Grading

U2 - 10.1136/jclinpath-2014-202294

DO - 10.1136/jclinpath-2014-202294

M3 - Article

C2 - 25185140

SN - 0021-9746

VL - 67

SP - 1106

EP - 1108

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 12

ER -

Grading of breast cancer on needle core biopsy: does a reduction in mitotic count threshold improve agreement with grade on excised specimens?

Abstract

Keywords / Materials (for Non-textual outputs)

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