Graft dysfunction following liver transplantation: Role of free radicals

KI Bzeizi, R Dawkes, NJF Dodd, JN Plevris, PC Hayes

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: Following orthotopic liver transplantation primary graft non-function occurs in about 10% of patients, and survival depends on early retransplantation. The aetiology has yet to be defined, but reperfusion injury as a result of free radical production has been considered as a possible mechanism. In this study we looked for evidence of free radical generation intraoperatively and assessed the relationship between free radical production and graft function.

Methods/Results: Twenty-one patients (M:F 10:11, mean age; 53+/-3.8 years) who underwent liver transplantation for end-stage liver disease were studied. Free radical activity increased significantly following reperfusion, as shown by: (i) the diene conjugated method, where the percentage molar ratio increased from a baseline of 10.87+/-0.78% to 24.42+/-7.8% (p

Conclusion: Free radical activity is increased following reperfusion of liver graft during transplantation, and the magnitude of the rise is related to the severity of graft dysfunction.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalJournal of Hepatology
Volume26
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • free radicals
  • liver transplantation
  • primary non-function
  • reperfusion injury
  • ISCHEMIA-REPERFUSION INJURY
  • PLATELET-ACTIVATING FACTOR
  • PERFUSED-RAT-LIVER
  • CORONARY SINUS
  • ADHESION
  • ANGIOPLASTY
  • ENDOTHELIUM
  • NEUTROPHILS
  • GMP-140
  • BLOOD

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