Abstract / Description of output
Background/Aims: Following orthotopic liver transplantation primary graft non-function occurs in about 10% of patients, and survival depends on early retransplantation. The aetiology has yet to be defined, but reperfusion injury as a result of free radical production has been considered as a possible mechanism. In this study we looked for evidence of free radical generation intraoperatively and assessed the relationship between free radical production and graft function.
Methods/Results: Twenty-one patients (M:F 10:11, mean age; 53+/-3.8 years) who underwent liver transplantation for end-stage liver disease were studied. Free radical activity increased significantly following reperfusion, as shown by: (i) the diene conjugated method, where the percentage molar ratio increased from a baseline of 10.87+/-0.78% to 24.42+/-7.8% (p
Conclusion: Free radical activity is increased following reperfusion of liver graft during transplantation, and the magnitude of the rise is related to the severity of graft dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 69-74 |
| Number of pages | 6 |
| Journal | Journal of Hepatology |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1997 |
Keywords / Materials (for Non-textual outputs)
- free radicals
- liver transplantation
- primary non-function
- reperfusion injury
- ISCHEMIA-REPERFUSION INJURY
- PLATELET-ACTIVATING FACTOR
- PERFUSED-RAT-LIVER
- CORONARY SINUS
- ADHESION
- ANGIOPLASTY
- ENDOTHELIUM
- NEUTROPHILS
- GMP-140
- BLOOD