Granular cell tumor in a lumbar spinal nerve of a dog

Deepa Rao, Helena Rylander, Randi Drees, Tobias Schwarz, Howard Steinberg

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

A 2-year-old Great Dane dog with a 2.5-week history of progressive paraparesis was presented to the Veterinary Medical Teaching Hospital at the University of Wisconsin-Madison. Neurologic examination revealed nonambulatory paraparesis with reduced to absent withdrawal hind-limb reflexes and lumbar pain. Magnetic resonance imaging and gross pathology confirmed a-larger regional lumbar mass and a second smaller extradural mass within the spinal canal. The left lumbar mass was associated with extensive hemorrhage; dissection showed a dark-red, soft, well-circumscribed mass measuring 2 cm x 1.5 cm x 0.5 cm within the left fourth lumbar spinal nerve. Histopathological evaluation with immunohistochemistry revealed sheets of round to polygonal cells with diffuse granular cytoplasm demonstrating diastase-resistant periodic acid Schiff reactivity and positive immunoexpression of S100 and neuron-specific enolase. The smaller extradural mass within the spinal canal exhibited similar morphology. Based on gross, histological, and immunohistochemical evidence, the masses were diagnosed as granular cell tumor.

Original languageEnglish
Pages (from-to)638-642
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Issue number4
Publication statusPublished - Jul 2010

Keywords / Materials (for Non-textual outputs)

  • Canine
  • Dogs
  • Granular cell tumor
  • Immunohistochemistry
  • S100
  • Spinal Nerve


Dive into the research topics of 'Granular cell tumor in a lumbar spinal nerve of a dog'. Together they form a unique fingerprint.

Cite this