Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092)

Nikola Sprigg, Philip M Bath, Lian Zhao, Mark R Willmot, Laura J Gray, Marion F Walker, Martin S Dennis, Nigel Russell

Research output: Contribution to journalArticlepeer-review

Abstract

Loss of motor function is common after stroke and leads to significant chronic disability. Stem cells are capable of self-renewal and of differentiating into multiple cell types, including neurones, glia, and vascular cells. We assessed the safety of granulocyte-colony-stimulating factor (G-CSF) after stroke and its effect on circulating CD34+ stem cells.
Original languageEnglish
Pages (from-to)2979-83
Number of pages5
JournalStroke
Volume37
Issue number12
DOIs
Publication statusPublished - 2006

Keywords

  • Aged
  • Bone Marrow Transplantation
  • Brain Ischemia
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Granulocyte Colony Stimulating Factor, Recombinant
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Male
  • Pilot Projects
  • Prospective Studies
  • Stroke

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