Gray matter nulled and vascular space occupancy dependent fMRI response to visual stimulation during hypoxic hypoxia

Yuji Shen, Yi-Ching L. Ho, Rishma Vidyasagar, George Balanos, Xavier Golay, Ida M. Pu, Risto A. Kauppinen

Research output: Contribution to journalArticlepeer-review

Abstract

Two cerebral blood volume (CBV)-weighted fMRI techniques, gray matter nulled (GMN) and vascular space occupancy (VASO)-dependent techniques at spatial resolution of 2 x 2 x 5 mm(3), were compared in the study investigating functional responses in the human visual cortex to stimulation in normoxia (inspired O-2=21%) and mild hypoxic hypoxia (inspired O-2 = 12%). GMN and VASO signals and T-2* were quantified in activated voxels. While the CBV-weighted signal changes in voxels activated by visual stimulation were similar in amplitude in both fMRI techniques in both oxygenation conditions, the number of activated voxels during hypoxic hypoxia was significantly reduced by 72 +/- 22% in GMN fMRI and 66 +/- 23% in VASO fMRI. T-2* prolonged in GMN and VASO activated voxels in normoxia by 1.6 +/- 0.5 ms and 1.7 +/- 0.5 ms, respectively. In hypoxia, however, T-2* shortened in GMN-activated voxels by 0.7 +/- 0.6 ms (p

Original languageEnglish
Pages (from-to)3450-3456
Number of pages7
JournalNeuroImage
Volume59
Issue number4
DOIs
Publication statusPublished - 15 Feb 2012

Keywords

  • VASO
  • HUMAN BRAIN
  • BOLD
  • FLOW
  • LEVEL
  • PERFUSION MRI
  • fMRI
  • RELAXATION
  • ACTIVATION
  • GMN
  • 3.0 TESLA
  • OXYGEN-SATURATION
  • CEREBRAL BLOOD-VOLUME

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