Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer

Susan McCarthy, Andrea Caporali, Steve Enkemann, Maurizio Scaltriti, Steve Eschrich, Pierpaola Davalli, Arnaldo Corti, Alice Lee, Jimmy Sung, Timothy J Yeatman, Saverio Bettuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Green tea catechins (GTCs) exert chemopreventive effects in many cancer models. Several studies implicate the DNA synthesis marker minichromosome maintenance protein 7 (MCM7) in prostate cancer progression, growth and invasion; representing a novel therapeutic target. In this study, we investigated the effect of GTCs on MCM7 expression in the transgenic adenocarcinoma mouse prostate model (TRAMP). DNA microarray, immunohistochemistry and western blot analysis showed that GTCs significantly suppressed MCM7 in the TRAMP mice treated with GTCs. Our study indicates that the cellular DNA replication factor MCM7 is involved in prostate cancer (CaP) and MCM7 gene expression was reduced by GTCs. Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role.
Original languageEnglish
Pages (from-to)196-204
Number of pages9
JournalMolecular Oncology
Volume1
Issue number2
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Adenocarcinoma
  • Animals
  • Catechin
  • Cell Cycle Proteins
  • DNA Replication
  • DNA, Neoplasm
  • DNA-Binding Proteins
  • Gene Expression Regulation, Neoplastic
  • Male
  • Mice
  • Mice, Transgenic
  • Neoplasms, Experimental
  • Nuclear Proteins
  • Prostatic Neoplasms
  • Tea
  • Tumor Markers, Biological

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