Growth factor signaling permits hypoxia-induced autophagy by a HIF1alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells

Simon Wilkinson, Kevin M Ryan

Research output: Contribution to journalArticlepeer-review

Abstract

Several recent reports have demonstrated that autophagy is induced in response to hypoxia in cultured cells. However, the mechanism and consequence of hypoxia-induced autophagy remains unclear as there is no consensus between these studies. In our recent report we show that, in human cancer cells, hypoxia cooperates with growth factor signaling to facilitate a HIF1alpha-driven transcriptional response that promotes autophagy. Here we summarize these findings and set them in context of the findings of other groups, concluding that there are likely multiple routes to different forms of autophagy that serve different purposes downstream of hypoxia, depending upon the degree of stress and cellular context.
Original languageEnglish
Pages (from-to)1068-9
Number of pages2
JournalAutophagy
Volume5
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint Dive into the research topics of 'Growth factor signaling permits hypoxia-induced autophagy by a HIF1alpha-dependent, BNIP3/3L-independent transcriptional program in human cancer cells'. Together they form a unique fingerprint.

Cite this