GSNOR-mediated de-nitrosylation in the plant defence response

Saad I. Malik, Adil Hussain, Byung-Wook Yun, Steven H. Spoel, Gary J. Loake

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

A key feature of the plant defence response is the transient engagement of a nitrosative burst, resulting in the synthesis of reactive nitrogen intermediates (RNIs). Specific, highly reactive cysteine (Cys) residues of low pK(a) are a major site of action for these intermediates. The addition of an NO moiety to a Cys thiol to form an S-nitrosothiol (SNO), is termed S-nitrosylation. This redox-based post-translational modification is emerging as a key regulator of protein function in plant immunity. Here we highlight recent advances in our understanding of de-nitrosylation, the mechanism that depletes protein SNOs, with a focus on S-nitrosoglutathione reductase (GSNOR). This enzyme controls total cellular S-nitrosylation indirectly during the defence response by turning over S-nitrosoglutathione (GSNO), a major cache of NO bioactivity. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)540-544
Number of pages5
JournalPlant science
Volume181
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • s-nitrosylation
  • GSNOR
  • De-nitrosylation
  • disease resistance
  • plant defence response

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