Guidelines for performing Mendelian randomization investigations

Stephen Burgess*, George Davey Smith, Neil M. Davies, Frank Dudbridge, Dipender Gill, M. Maria Glymour, Fernando P. Hartwig, Michael V. Holmes, Cosetta Minelli, Caroline L. Relton, Evropi Theodoratou

*Corresponding author for this work

Research output: Other contributionProtocols

Abstract / Description of output

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.

Original languageEnglish
Publication statusPublished - 28 Apr 2020

Publication series

NameWellcome Open Research
PublisherF1000 Research Ltd.
ISSN (Print)2398-502X

Keywords / Materials (for Non-textual outputs)

  • Causal inference
  • Genetic epidemiology
  • Guidelines
  • Mendelian randomization


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