Guidelines for performing Mendelian randomization investigations: update for summer 2023

Stephen Burgess, George Davey Smith, Neil M Davies, Frank Dudbridge, Dipender Gill, M. Maria Glymour, Fernando Pires Hartwig, Zoltán Kutalik, Michael V Holmes, Cosetta Minelli, Jean V Morrison, Wei Pan, Caroline L. Relton, Evropi Theodoratou

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.
Original languageEnglish
Article number186
Number of pages34
JournalWellcome Open Research
Publication statusPublished - 4 Aug 2023

Keywords / Materials (for Non-textual outputs)

  • Mendelian randomization
  • guidelines
  • genetic epidemiology
  • causal inference


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