Guidelines for performing Mendelian randomization investigations: update for summer 2023

Stephen Burgess; George  Davey Smith; Neil M Davies; Frank Dudbridge; Dipender  Gill; M. Maria Glymour; Fernando Pires Hartwig; Zoltán Kutalik; Michael V Holmes; Cosetta Minelli; Jean V Morrison; Wei Pan; Caroline L. Relton; Evropi Theodoratou

doi:10.12688/wellcomeopenres.15555.3

Guidelines for performing Mendelian randomization investigations: update for summer 2023

Stephen Burgess, George Davey Smith, Neil M Davies, Frank Dudbridge, Dipender Gill, M. Maria Glymour, Fernando Pires Hartwig, Zoltán Kutalik, Michael V Holmes, Cosetta Minelli, Jean V Morrison, Wei Pan, Caroline L. Relton, Evropi Theodoratou

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.

Original language	English
Article number	186
Number of pages	34
Journal	Wellcome Open Research
Volume	4
DOIs	https://doi.org/10.12688/wellcomeopenres.15555.3
Publication status	Published - 4 Aug 2023

Keywords / Materials (for Non-textual outputs)

Mendelian randomization
guidelines
genetic epidemiology
causal inference

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10.12688/wellcomeopenres.15555.3Licence: Creative Commons: Attribution (CC-BY)

Guidelines for performing_BURGESS_DOA04082023_VOR_CC-BYFinal published version, 1.43 MBLicence: Creative Commons: Attribution (CC-BY)

https://wellcomeopenresearch.org/articles/4-186Licence: Creative Commons: Attribution (CC-BY)

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Guidelines for performing Mendelian randomization investigations - update for summer 2023
Accepted author manuscript, 1.12 MB
Licence: Creative Commons: Attribution (CC-BY)

A feasibility study for the detection of tumour DNA in stool collected with the faecal immunochemical test (FIT) from patients with colorectal neoplasia.
Theodoratou, E., Din, F., Dunlop, M. & Farrington, S.
UK-based charities
1/07/18 → 31/03/23
Project: Research

Cite this

Burgess, S., Davey Smith, G., Davies, N. M., Dudbridge, F., Gill, D., Glymour, M. M., Hartwig, F. P., Kutalik, Z., Holmes, M. V., Minelli, C., Morrison, J. V., Pan, W., Relton, C. L., & Theodoratou, E. (2023). Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Research , 4, Article 186. https://doi.org/10.12688/wellcomeopenres.15555.3

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title = "Guidelines for performing Mendelian randomization investigations: update for summer 2023",

abstract = "This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 24 months.",

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AU - Glymour, M. Maria

AU - Hartwig, Fernando Pires

AU - Kutalik, Zoltán

AU - Holmes, Michael V

AU - Minelli, Cosetta

AU - Morrison, Jean V

AU - Pan, Wei

AU - Relton, Caroline L.

AU - Theodoratou, Evropi

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Guidelines for performing Mendelian randomization investigations: update for summer 2023

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Embargoed Document

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Projects

A feasibility study for the detection of tumour DNA in stool collected with the faecal immunochemical test (FIT) from patients with colorectal neoplasia.

Cite this