Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

Xiaoyuan Zhou; Ryan Baumann; Xiaohui Gao; Myra Mendoza; Sneha Singh; Ilana Katz Sand; Zongqi Xia; Laura M. Cox; Tanuja Chitnis; Hongsup Yoon; Laura Moles; Stacy J. Caillier; Adam Santaniello; Gail Ackermann; Adil Harroud; Robin Lincoln; Refujia Gomez; Antonio González Peña; Elise Digga; Daniel Joseph Hakim; Yoshiki Vazquez-baeza; Karthik Soman; Shannon Warto; Greg Humphrey; Mauricio Farez; Lisa Ann Gerdes; Jorge R. Oksenberg; Scott S. Zamvil; Siddharthan Chandran; Peter Connick; David Otaegui; Tamara Castillo-triviño; Stephen L. Hauser; Jeffrey M. Gelfand; Howard L. Weiner; Reinhard Hohlfeld; Hartmut Wekerle; Jennifer Graves; Amit Bar-or; Bruce A.c. Cree; Jorge Correale; Rob Knight; Sergio E. Baranzini

doi:10.1016/j.cell.2022.08.021

Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

Xiaoyuan Zhou, Ryan Baumann, Xiaohui Gao, Myra Mendoza, Sneha Singh, Ilana Katz Sand, Zongqi Xia, Laura M. Cox, Tanuja Chitnis, Hongsup Yoon, Laura Moles, Stacy J. Caillier, Adam Santaniello, Gail Ackermann, Adil Harroud, Robin Lincoln, Refujia Gomez, Antonio González Peña, Elise Digga, Daniel Joseph HakimYoshiki Vazquez-baeza, Karthik Soman, Shannon Warto, Greg Humphrey, Mauricio Farez, Lisa Ann Gerdes, Jorge R. Oksenberg, Scott S. Zamvil, Siddharthan Chandran, Peter Connick, David Otaegui, Tamara Castillo-triviño, Stephen L. Hauser, Jeffrey M. Gelfand, Howard L. Weiner, Reinhard Hohlfeld, Hartmut Wekerle, Jennifer Graves, Amit Bar-or, Bruce A.c. Cree, Jorge Correale, Rob Knight, Sergio E. Baranzini

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	3467-3486.e16
Journal	Cell
Volume	185
Issue number	19
DOIs	https://doi.org/10.1016/j.cell.2022.08.021
Publication status	Published - 15 Sep 2022

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10.1016/j.cell.2022.08.021

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https://linkinghub.elsevier.com/retrieve/pii/S0092867422011151

Cite this

Zhou, X., Baumann, R., Gao, X., Mendoza, M., Singh, S., Katz Sand, I., Xia, Z., Cox, L. M., Chitnis, T., Yoon, H., Moles, L., Caillier, S. J., Santaniello, A., Ackermann, G., Harroud, A., Lincoln, R., Gomez, R., González Peña, A., Digga, E., ... Baranzini, S. E. (2022). Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course. Cell, 185(19), 3467-3486.e16. https://doi.org/10.1016/j.cell.2022.08.021

@article{622fe4d6104f4395a6431ce1ef768350,

title = "Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course",

author = "Xiaoyuan Zhou and Ryan Baumann and Xiaohui Gao and Myra Mendoza and Sneha Singh and {Katz Sand}, Ilana and Zongqi Xia and Cox, {Laura M.} and Tanuja Chitnis and Hongsup Yoon and Laura Moles and Caillier, {Stacy J.} and Adam Santaniello and Gail Ackermann and Adil Harroud and Robin Lincoln and Refujia Gomez and {Gonz{\'a}lez Pe{\~n}a}, Antonio and Elise Digga and Hakim, {Daniel Joseph} and Yoshiki Vazquez-baeza and Karthik Soman and Shannon Warto and Greg Humphrey and Mauricio Farez and Gerdes, {Lisa Ann} and Oksenberg, {Jorge R.} and Zamvil, {Scott S.} and Siddharthan Chandran and Peter Connick and David Otaegui and Tamara Castillo-trivi{\~n}o and Hauser, {Stephen L.} and Gelfand, {Jeffrey M.} and Weiner, {Howard L.} and Reinhard Hohlfeld and Hartmut Wekerle and Jennifer Graves and Amit Bar-or and Cree, {Bruce A.c.} and Jorge Correale and Rob Knight and Baranzini, {Sergio E.}",

note = "Funding Information: Major funding for this work was provided by the Valhalla Foundation. This work was also supported by the Salah Foundation and the UCSF Benioff Center for Microbiome Medicine. R.H. and L.A.G. are supported by the National MS Society USA (RFA-2104-37464), Deutsche Forschungsgemeinschaft (DFG,German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198), the Gemeinn{\"u}tzige Hertie Stiftung, Bavarian association and national association of the German MS society (DMSG), Dr. Leopold And Carmen Ellinger Foundation, and the association {"}Verein zur Therapieforschung f{\"u}r MS Kranke e.V.” Z.X. has received research support from the National Institutes of Health and the Department of Defense. L.M.C. is supported by the Race to Erase MS Early Investigator Award. H.L.W. is supported by NIH/NINDS award R01NS087226. S.L.H. is supported by NIH/NINDS award 5R35NS111644. S.E.B. holds the Heidrich Family and Friends endowed chair in Neurology at UCSF. S.E.B. holds the Professorship in Neurology I at UCSF. Conceptualization, S.E.B. I.K.S. S.C. S.L.H. B.A.C.C. H.L.W. R.H. H.W. J.C. and R.K.; Methodology, R.B. Y.V.-B. S.J.C. A.G.P. G.H. G.A. and R.K.; Software, X.Z. A.S. and D.J.H.; Validation, X.G. and R.B.; Formal Analysis, X.Z. D.J.H. and S.E.B.; Investigation, X.Z. I.K.S. Z.X. L.M.C. T.C. H.Y. L.M. A.H. M.F. L.A.G. J.R.O. S.S.Z. D.O. S.L.H. B.A.C.C. H.L.W. R.H. H.W. J.G. and J.C.; Resources, R.L. X.G. M.M. S.S. Z.X. S.J.C. A.H. E.D. M.F. L.A.G. J.R.O. S.S.Z. S.C. P.C. T.C.-T. S.L.H. J.M.G. B.A.C.C. J.G. A.B.-O. and J.C.; Data Curation, X.Z. M.M. S.S. A.S. R.G. and E.D.; Writing – Original Draft, X.Z. and S.E.B.; Writing – Review & Editing, X.Z. I.K.S. Z.X. L.M.C. S.L.H. J.C. and S.E.B.; Visualization, X.Z.; Supervision, S.E.B.; Project Administration, R.L. and S.W.; Funding Acquisition, S.E.B. and S.L.H. The authors declare no competing interests. We worked to ensure that the study questionnaires were prepared in an inclusive way. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in science. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. Funding Information: Major funding for this work was provided by the Valhalla Foundation . This work was also supported by the Salah Foundation and the UCSF Benioff Center for Microbiome Medicine. R.H. and L.A.G. are supported by the National MS Society USA ( RFA-2104-37464 ), Deutsche Forschungsgemeinschaft (DFG,German Research Foundation) under Germany{\textquoteright}s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198), the Gemeinn{\"u}tzige Hertie Stiftung , Bavarian association and national association of the German MS society ( DMSG ), Dr. Leopold And Carmen Ellinger Foundation , and the association {"} Verein zur Therapieforschung f{\"u}r MS Kranke e.V .” Z.X. has received research support from the National Institutes of Health and the Department of Defense . L.M.C. is supported by the Race to Erase MS Early Investigator Award. H.L.W. is supported by NIH / NINDS award R01NS087226 . S.L.H. is supported by NIH / NINDS award 5R35NS111644 . S.E.B. holds the Heidrich Family and Friends endowed chair in Neurology at UCSF. S.E.B. holds the Professorship in Neurology I at UCSF. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

month = sep,

day = "15",

doi = "10.1016/j.cell.2022.08.021",

language = "English",

volume = "185",

pages = "3467--3486.e16",

journal = "Cell",

issn = "0092-8674",

publisher = "Cell Press",

number = "19",

}

Zhou, X, Baumann, R, Gao, X, Mendoza, M, Singh, S, Katz Sand, I, Xia, Z, Cox, LM, Chitnis, T, Yoon, H, Moles, L, Caillier, SJ, Santaniello, A, Ackermann, G, Harroud, A, Lincoln, R, Gomez, R, González Peña, A, Digga, E, Hakim, DJ, Vazquez-baeza, Y, Soman, K, Warto, S, Humphrey, G, Farez, M, Gerdes, LA, Oksenberg, JR, Zamvil, SS, Chandran, S, Connick, P, Otaegui, D, Castillo-triviño, T, Hauser, SL, Gelfand, JM, Weiner, HL, Hohlfeld, R, Wekerle, H, Graves, J, Bar-or, A, Cree, BAC, Correale, J, Knight, R & Baranzini, SE 2022, 'Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course', Cell, vol. 185, no. 19, pp. 3467-3486.e16. https://doi.org/10.1016/j.cell.2022.08.021

TY - JOUR

T1 - Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course

AU - Zhou, Xiaoyuan

AU - Baumann, Ryan

AU - Gao, Xiaohui

AU - Mendoza, Myra

AU - Singh, Sneha

AU - Katz Sand, Ilana

AU - Xia, Zongqi

AU - Cox, Laura M.

AU - Chitnis, Tanuja

AU - Yoon, Hongsup

AU - Moles, Laura

AU - Caillier, Stacy J.

AU - Santaniello, Adam

AU - Ackermann, Gail

AU - Harroud, Adil

AU - Lincoln, Robin

AU - Gomez, Refujia

AU - González Peña, Antonio

AU - Digga, Elise

AU - Hakim, Daniel Joseph

AU - Vazquez-baeza, Yoshiki

AU - Soman, Karthik

AU - Warto, Shannon

AU - Humphrey, Greg

AU - Farez, Mauricio

AU - Gerdes, Lisa Ann

AU - Oksenberg, Jorge R.

AU - Zamvil, Scott S.

AU - Chandran, Siddharthan

AU - Connick, Peter

AU - Otaegui, David

AU - Castillo-triviño, Tamara

AU - Hauser, Stephen L.

AU - Gelfand, Jeffrey M.

AU - Weiner, Howard L.

AU - Hohlfeld, Reinhard

AU - Wekerle, Hartmut

AU - Graves, Jennifer

AU - Bar-or, Amit

AU - Cree, Bruce A.c.

AU - Correale, Jorge

AU - Knight, Rob

AU - Baranzini, Sergio E.

N1 - Funding Information: Major funding for this work was provided by the Valhalla Foundation. This work was also supported by the Salah Foundation and the UCSF Benioff Center for Microbiome Medicine. R.H. and L.A.G. are supported by the National MS Society USA (RFA-2104-37464), Deutsche Forschungsgemeinschaft (DFG,German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198), the Gemeinnützige Hertie Stiftung, Bavarian association and national association of the German MS society (DMSG), Dr. Leopold And Carmen Ellinger Foundation, and the association "Verein zur Therapieforschung für MS Kranke e.V.” Z.X. has received research support from the National Institutes of Health and the Department of Defense. L.M.C. is supported by the Race to Erase MS Early Investigator Award. H.L.W. is supported by NIH/NINDS award R01NS087226. S.L.H. is supported by NIH/NINDS award 5R35NS111644. S.E.B. holds the Heidrich Family and Friends endowed chair in Neurology at UCSF. S.E.B. holds the Professorship in Neurology I at UCSF. Conceptualization, S.E.B. I.K.S. S.C. S.L.H. B.A.C.C. H.L.W. R.H. H.W. J.C. and R.K.; Methodology, R.B. Y.V.-B. S.J.C. A.G.P. G.H. G.A. and R.K.; Software, X.Z. A.S. and D.J.H.; Validation, X.G. and R.B.; Formal Analysis, X.Z. D.J.H. and S.E.B.; Investigation, X.Z. I.K.S. Z.X. L.M.C. T.C. H.Y. L.M. A.H. M.F. L.A.G. J.R.O. S.S.Z. D.O. S.L.H. B.A.C.C. H.L.W. R.H. H.W. J.G. and J.C.; Resources, R.L. X.G. M.M. S.S. Z.X. S.J.C. A.H. E.D. M.F. L.A.G. J.R.O. S.S.Z. S.C. P.C. T.C.-T. S.L.H. J.M.G. B.A.C.C. J.G. A.B.-O. and J.C.; Data Curation, X.Z. M.M. S.S. A.S. R.G. and E.D.; Writing – Original Draft, X.Z. and S.E.B.; Writing – Review & Editing, X.Z. I.K.S. Z.X. L.M.C. S.L.H. J.C. and S.E.B.; Visualization, X.Z.; Supervision, S.E.B.; Project Administration, R.L. and S.W.; Funding Acquisition, S.E.B. and S.L.H. The authors declare no competing interests. We worked to ensure that the study questionnaires were prepared in an inclusive way. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in science. The author list of this paper includes contributors from the location where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. Funding Information: Major funding for this work was provided by the Valhalla Foundation . This work was also supported by the Salah Foundation and the UCSF Benioff Center for Microbiome Medicine. R.H. and L.A.G. are supported by the National MS Society USA ( RFA-2104-37464 ), Deutsche Forschungsgemeinschaft (DFG,German Research Foundation) under Germany’s Excellence Strategy within the framework of the Munich Cluster for Systems Neurology (EXC 2145 SyNergy – ID 390857198), the Gemeinnützige Hertie Stiftung , Bavarian association and national association of the German MS society ( DMSG ), Dr. Leopold And Carmen Ellinger Foundation , and the association " Verein zur Therapieforschung für MS Kranke e.V .” Z.X. has received research support from the National Institutes of Health and the Department of Defense . L.M.C. is supported by the Race to Erase MS Early Investigator Award. H.L.W. is supported by NIH / NINDS award R01NS087226 . S.L.H. is supported by NIH / NINDS award 5R35NS111644 . S.E.B. holds the Heidrich Family and Friends endowed chair in Neurology at UCSF. S.E.B. holds the Professorship in Neurology I at UCSF. Publisher Copyright: © 2022 Elsevier Inc.

PY - 2022/9/15

Y1 - 2022/9/15

U2 - 10.1016/j.cell.2022.08.021

DO - 10.1016/j.cell.2022.08.021

M3 - Article

VL - 185

SP - 3467-3486.e16

JO - Cell

JF - Cell

SN - 0092-8674

IS - 19

ER -