Gut mucosal DAMPs in IBD: From mechanisms to therapeutic implications

Ray Kiran Boyapati, Adriano Rossi, Jack Satsangi, Gwo-Tzer Ho

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Endogenous damage associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human diseases. The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD) are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this review, we use IBD as an archetypal common chronic inflammatory disease to focus on the conceptual and evidential importance of DAMPs in pathogenesis and why DAMPs represent an entirely new class of targets for clinical translation.
Original languageEnglish
JournalMucosal Immunology
Early online date2 Mar 2016
DOIs
Publication statusE-pub ahead of print - 2 Mar 2016

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