Projects per year
Abstract
Endogenous damage associated molecular patterns (DAMPs) are released during tissue damage and have increasingly recognized roles in the etiology of many human diseases. The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD) are immune-mediated conditions where high levels of DAMPs are observed. DAMPs such as calprotectin (S100A8/9) have an established clinical role as a biomarker in IBD. In this review, we use IBD as an archetypal common chronic inflammatory disease to focus on the conceptual and evidential importance of DAMPs in pathogenesis and why DAMPs represent an entirely new class of targets for clinical translation.
Original language | English |
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Journal | Mucosal Immunology |
Early online date | 2 Mar 2016 |
DOIs | |
Publication status | E-pub ahead of print - 2 Mar 2016 |
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Dive into the research topics of 'Gut mucosal DAMPs in IBD: From mechanisms to therapeutic implications'. Together they form a unique fingerprint.Projects
- 2 Finished
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Mitochondria damage associated molecular patterns in IBD
1/12/14 → 1/06/16
Project: University Awarded Project Funding
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Modulation of a P-glycoptotien 170 function as a therapeutic target in the ulcerative cells.
1/12/08 → 30/11/13
Project: Research