GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

The LifeLines Cohort Study; Cornelius A Rietveld; Sarah E Medland; Jaime Derringer; Jian Yang; Tõnu Esko; Nicolas W Martin; Harm-Jan Westra; Konstantin Shakhbazov; Abdel Abdellaoui; Arpana Agrawal; Eva Albrecht; Behrooz Z Alizadeh; Najaf Amin; John Barnard; Sebastian E Baumeister; Kelly S Benke; Lawrence F Bielak; Jeffrey A Boatman; Patricia A Boyle; Gail Davies; Christiaan de Leeuw; Niina Eklund; Daniel S Evans; Rudolf Ferhmann; Krista Fischer; Christian Gieger; Håkon K Gjessing; Sara Hägg; Jennifer R Harris; Caroline Hayward; Christina Holzapfel; Carla A Ibrahim-Verbaas; Erik Ingelsson; Bo Jacobsson; Peter Joshi; Astanand Jugessur; Marika Kaakinen; Stavroula Kanoni; Juha Karjalainen; Ivana Kolcic; Veronique Vitart; Harry Campbell; Ian J Deary; Nicholas D Hastie; David C Liewald; Igor Rudan; John M Starr; James F Wilson; Alan F Wright; Peter M Visscher

doi:10.1126/science.1235488

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

The LifeLines Cohort Study, Cornelius A Rietveld, Sarah E Medland, Jaime Derringer, Jian Yang, Tõnu Esko, Nicolas W Martin, Harm-Jan Westra, Konstantin Shakhbazov, Abdel Abdellaoui, Arpana Agrawal, Eva Albrecht, Behrooz Z Alizadeh, Najaf Amin, John Barnard, Sebastian E Baumeister, Kelly S Benke, Lawrence F Bielak, Jeffrey A Boatman, Patricia A BoyleGail Davies, Christiaan de Leeuw, Niina Eklund, Daniel S Evans, Rudolf Ferhmann, Krista Fischer, Christian Gieger, Håkon K Gjessing, Sara Hägg, Jennifer R Harris, Caroline Hayward, Christina Holzapfel, Carla A Ibrahim-Verbaas, Erik Ingelsson, Bo Jacobsson, Peter Joshi, Astanand Jugessur, Marika Kaakinen, Stavroula Kanoni, Juha Karjalainen, Ivana Kolcic, Veronique Vitart, Harry Campbell, Ian J Deary, Nicholas D Hastie, David C Liewald, Igor Rudan, John M Starr, James F Wilson, Alan F Wright, Peter M Visscher

Research output: Contribution to journal › Article › peer-review

Abstract

A genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈ 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

Original language	English
Pages (from-to)	1467-1471
Number of pages	5
Journal	Science
Volume	340
Issue number	6139
Early online date	30 May 2013
DOIs	https://doi.org/10.1126/science.1235488
Publication status	Published - 21 Jun 2013

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10.1126/science.1235488

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with
Published in final edited form as: Science. 2013 June 21; 340(6139): 1467–1471. doi:10.1126/science.1235488.
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http://www.sciencemag.org/content/340/6139/1467

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Disconnected Mind [Phase 2]
Wardlaw, J.
UK-based charities
1/01/11 → 31/03/16
Project: Research

Cite this

The LifeLines Cohort Study, Rietveld, C. A., Medland, S. E., Derringer, J., Yang, J., Esko, T., Martin, N. W., Westra, H.-J., Shakhbazov, K., Abdellaoui, A., Agrawal, A., Albrecht, E., Alizadeh, B. Z., Amin, N., Barnard, J., Baumeister, S. E., Benke, K. S., Bielak, L. F., Boatman, J. A., ... Visscher, P. M. (2013). GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340(6139), 1467-1471. https://doi.org/10.1126/science.1235488

@article{0f76c4b9f0ef4512a24cab2e8cb936ff,

title = "GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment",

abstract = "A genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈ 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.",

author = "{The LifeLines Cohort Study} and Rietveld, {Cornelius A} and Medland, {Sarah E} and Jaime Derringer and Jian Yang and T{\~o}nu Esko and Martin, {Nicolas W} and Harm-Jan Westra and Konstantin Shakhbazov and Abdel Abdellaoui and Arpana Agrawal and Eva Albrecht and Alizadeh, {Behrooz Z} and Najaf Amin and John Barnard and Baumeister, {Sebastian E} and Benke, {Kelly S} and Bielak, {Lawrence F} and Boatman, {Jeffrey A} and Boyle, {Patricia A} and Gail Davies and {de Leeuw}, Christiaan and Niina Eklund and Evans, {Daniel S} and Rudolf Ferhmann and Krista Fischer and Christian Gieger and Gjessing, {H{\aa}kon K} and Sara H{\"a}gg and Harris, {Jennifer R} and Caroline Hayward and Christina Holzapfel and Ibrahim-Verbaas, {Carla A} and Erik Ingelsson and Bo Jacobsson and Peter Joshi and Astanand Jugessur and Marika Kaakinen and Stavroula Kanoni and Juha Karjalainen and Ivana Kolcic and Veronique Vitart and Harry Campbell and Deary, {Ian J} and Hastie, {Nicholas D} and Liewald, {David C} and Igor Rudan and Starr, {John M} and Wilson, {James F} and Wright, {Alan F} and Visscher, {Peter M}",

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The LifeLines Cohort Study, Rietveld, CA, Medland, SE, Derringer, J, Yang, J, Esko, T, Martin, NW, Westra, H-J, Shakhbazov, K, Abdellaoui, A, Agrawal, A, Albrecht, E, Alizadeh, BZ, Amin, N, Barnard, J, Baumeister, SE, Benke, KS, Bielak, LF, Boatman, JA, Boyle, PA, Davies, G, de Leeuw, C, Eklund, N, Evans, DS, Ferhmann, R, Fischer, K, Gieger, C, Gjessing, HK, Hägg, S, Harris, JR, Hayward, C, Holzapfel, C, Ibrahim-Verbaas, CA, Ingelsson, E, Jacobsson, B, Joshi, P, Jugessur, A, Kaakinen, M, Kanoni, S, Karjalainen, J, Kolcic, I, Vitart, V , Campbell, H , Deary, IJ, Hastie, ND, Liewald, DC, Rudan, I, Starr, JM, Wilson, JF, Wright, AF & Visscher, PM 2013, 'GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment', Science, vol. 340, no. 6139, pp. 1467-1471. https://doi.org/10.1126/science.1235488

TY - JOUR

T1 - GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

AU - The LifeLines Cohort Study

AU - Rietveld, Cornelius A

AU - Medland, Sarah E

AU - Derringer, Jaime

AU - Yang, Jian

AU - Esko, Tõnu

AU - Martin, Nicolas W

AU - Westra, Harm-Jan

AU - Shakhbazov, Konstantin

AU - Abdellaoui, Abdel

AU - Agrawal, Arpana

AU - Albrecht, Eva

AU - Alizadeh, Behrooz Z

AU - Amin, Najaf

AU - Barnard, John

AU - Baumeister, Sebastian E

AU - Benke, Kelly S

AU - Bielak, Lawrence F

AU - Boatman, Jeffrey A

AU - Boyle, Patricia A

AU - Davies, Gail

AU - de Leeuw, Christiaan

AU - Eklund, Niina

AU - Evans, Daniel S

AU - Ferhmann, Rudolf

AU - Fischer, Krista

AU - Gieger, Christian

AU - Gjessing, Håkon K

AU - Hägg, Sara

AU - Harris, Jennifer R

AU - Hayward, Caroline

AU - Holzapfel, Christina

AU - Ibrahim-Verbaas, Carla A

AU - Ingelsson, Erik

AU - Jacobsson, Bo

AU - Joshi, Peter

AU - Jugessur, Astanand

AU - Kaakinen, Marika

AU - Kanoni, Stavroula

AU - Karjalainen, Juha

AU - Kolcic, Ivana

AU - Vitart, Veronique

AU - Campbell, Harry

AU - Deary, Ian J

AU - Hastie, Nicholas D

AU - Liewald, David C

AU - Rudan, Igor

AU - Starr, John M

AU - Wilson, James F

AU - Wright, Alan F

AU - Visscher, Peter M

N1 - MC_PC_U127561128

PY - 2013/6/21

Y1 - 2013/6/21

N2 - A genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈ 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

AB - A genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent SNPs are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (R(2) ≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈ 2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.

U2 - 10.1126/science.1235488

DO - 10.1126/science.1235488

M3 - Article

C2 - 23722424

SN - 0036-8075

VL - 340

SP - 1467

EP - 1471

JO - Science

JF - Science

IS - 6139

ER -

GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment

Abstract

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Disconnected Mind [Phase 2]

Cite this