TY - JOUR
T1 - GWASs Identify Genetic Loci Associated with Human Scalp Hair Whorl Direction
AU - Luo, Junyu
AU - Huang, He
AU - Qiao, Hui
AU - Tan, Jingze
AU - Chen, Wenyan
AU - Zhang, Manfei
AU - Ruiz-Linares, Andrés
AU - Wang, Jiucun
AU - Yang, Yajun
AU - Jin, Li
AU - Headon, Denis J
AU - Wang, Sijia
N1 - Funding Information:
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (grant number XDB38020400 to SW), CAS Project for Young Scientists in Basic Research (grant number YSBR-077 ), National Science and Technology Basic Research Project (grant number 2015FY111700 ), the National Natural Science Foundation of China (grants number to 32271186 to JT), and CAMS Innovation Fund for Medical Sciences (2019-I2M-5-066).
Funding Information:
This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (grant number XDB38020400 to SW), CAS Project for Young Scientists in Basic Research (grant number YSBR-077), National Science and Technology Basic Research Project (grant number 2015FY111700), the National Natural Science Foundation of China (grants number to 32271186 to JT), and CAMS Innovation Fund for Medical Sciences (2019-I2M-5-066). Conceptualization: JLu, SW, DJH; Data Curation: JLu, HH, HQ, WC, MZ; Formal Analysis: JLu, HH, HQ, WC, MZ; Funding Acquisition: SW, JT, JLi; Investigation: JLu, HH, HQ, JT; Methodology: JLu, HH, HQ; Project Administration: SW; Resources: SW, JT, JLi, ARL, JW, YY; Supervision: SW, DJH; Validation: JLu, HH; Visualization: JLu, HH, SW; Writing - Original Draft Preparation: JLu, HH; Writing - Review and Editing: JLu, HH, DJH, SW, HQ, MZ
PY - 2023/10
Y1 - 2023/10
N2 - A hair whorl is a patch of hair growing in a circular pattern around a point specified by hair follicle (HF) orientations (Ziering and Krenitsky, 2003). As an easily observed human trait, established between 10 and 16 weeks of gestation (Smith and Gong, 1973), scalp hair whorl pattern is typically defined by the whorl number (single or double whorl) and whorl direction (e.g., clockwise, counterclockwise, or diffuse) (Ziering and Krenitsky, 2003). Because atypical whorl patterns have been observed in patients with abnormal neurological development (Smith and Gong, 1973), understanding the genetic basis of whorl patterns may help to unravel important biological processes. Because the clockwise or counterclockwise direction of a single whorl is highly stable within an individual and varies considerably between individuals and populations (Ziering and Krenitsky, 2003), it is the most likely feature to yield insight into the embryology and development of the whorl.
AB - A hair whorl is a patch of hair growing in a circular pattern around a point specified by hair follicle (HF) orientations (Ziering and Krenitsky, 2003). As an easily observed human trait, established between 10 and 16 weeks of gestation (Smith and Gong, 1973), scalp hair whorl pattern is typically defined by the whorl number (single or double whorl) and whorl direction (e.g., clockwise, counterclockwise, or diffuse) (Ziering and Krenitsky, 2003). Because atypical whorl patterns have been observed in patients with abnormal neurological development (Smith and Gong, 1973), understanding the genetic basis of whorl patterns may help to unravel important biological processes. Because the clockwise or counterclockwise direction of a single whorl is highly stable within an individual and varies considerably between individuals and populations (Ziering and Krenitsky, 2003), it is the most likely feature to yield insight into the embryology and development of the whorl.
U2 - 10.1016/j.jid.2023.04.008
DO - 10.1016/j.jid.2023.04.008
M3 - Letter
C2 - 37565938
SN - 0022-202X
VL - 143
SP - 2065-2068.e10
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 10
ER -