H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

Ulugbek B Nurmatov; Edmund Rhatigan; F Estelle R Simons; Aziz Sheikh

doi:10.1016/j.anai.2013.11.010

H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

Ulugbek B Nurmatov, Edmund Rhatigan, F Estelle R Simons, Aziz Sheikh

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

BACKGROUND: Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. Although H2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.

OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.

METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.

RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.

CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.

Original language	English
Pages (from-to)	126-131
Number of pages	6
Journal	Annals of Allergy, Asthma and Immunology
Volume	112
Issue number	2
DOIs	https://doi.org/10.1016/j.anai.2013.11.010
Publication status	Published - Feb 2014

Keywords / Materials (for Non-textual outputs)

Anaphylaxis
Anti-Allergic Agents
Epinephrine
Evidence-Based Medicine
Histamine H1 Antagonists
Histamine H2 Antagonists
Humans
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Shock

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10.1016/j.anai.2013.11.010

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title = "H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review",

abstract = "BACKGROUND: Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. Although H2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.",

keywords = "Anaphylaxis, Anti-Allergic Agents, Epinephrine, Evidence-Based Medicine, Histamine H1 Antagonists, Histamine H2 Antagonists, Humans, Practice Guidelines as Topic, Randomized Controlled Trials as Topic, Shock",

author = "Nurmatov, {Ulugbek B} and Edmund Rhatigan and Simons, {F Estelle R} and Aziz Sheikh",

year = "2014",

month = feb,

doi = "10.1016/j.anai.2013.11.010",

language = "English",

volume = "112",

pages = "126--131",

journal = "Annals of Allergy, Asthma and Immunology",

issn = "1081-1206",

publisher = "American College of Allergy, Asthma and Immunology",

number = "2",

}

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T1 - H2-antihistamines for the treatment of anaphylaxis with and without shock

T2 - a systematic review

AU - Nurmatov, Ulugbek B

AU - Rhatigan, Edmund

AU - Simons, F Estelle R

AU - Sheikh, Aziz

PY - 2014/2

Y1 - 2014/2

N2 - BACKGROUND: Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. Although H2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.

AB - BACKGROUND: Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. Although H2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.

KW - Anaphylaxis

KW - Anti-Allergic Agents

KW - Epinephrine

KW - Evidence-Based Medicine

KW - Histamine H1 Antagonists

KW - Histamine H2 Antagonists

KW - Humans

KW - Practice Guidelines as Topic

KW - Randomized Controlled Trials as Topic

KW - Shock

U2 - 10.1016/j.anai.2013.11.010

DO - 10.1016/j.anai.2013.11.010

M3 - Article

C2 - 24468252

SN - 1081-1206

VL - 112

SP - 126

EP - 131

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

IS - 2

ER -

H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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